godfather of surgery

Chapter 1046 A dead horse becomes a live doctor
According to Sisi's current condition, it is unlikely that she can go to school normally. Yang Ping had a long talk with Sisi's parents, hoping that Sisi could temporarily take a leave of absence from school for hospitalization.

Although a suitable treatment plan has not yet been found, hospitalization can provide symptomatic treatment, monitor the progression of the disease, and provide timely rescue when life is in danger.

In medical treatment plans, it can be divided into causal treatment and symptomatic treatment. Causal treatment is treatment for the cause of the disease, and symptomatic treatment is treatment for the symptoms. It can be simply understood as the difference between treating the root cause and treating the symptoms.

Unfortunately, at present, most of our treatment plans for diseases are symptomatic treatment, and only a very small number of diseases are treated at the cause.

That is to say, most diseases cannot be cured, only a very small number of diseases can be cured, and those diseases that seem to be curable actually only rely on the body's own immunity to recover, and medicine only provides assistance.

The most successful causal treatment is the treatment of bacterial infection. Before the emergence of penicillin, the mortality rate of bacterial infection was alarming, and any infectious disease could be fatal. Since the emergence of antibiotics such as penicillin, bacterial infectious diseases can be said to have been conquered by humans.

Antibiotics are used to treat and eliminate pathogenic bacteria, so once the bacteria are completely eliminated, the disease will naturally heal.

Therefore, there are only a few diseases that can be cured, and there are a lot of diseases that can be cured. The disease that humans are most likely to encounter is acute upper respiratory tract infection, which we commonly call "cold". The most common cold is a viral infection. At present, except for a very small number of viruses, there are no effective antiviral drugs for the vast majority of viruses.

In fact, all the drugs and methods used in modern medicine to treat colds can only relieve the symptoms of the disease, but cannot change the course of the disease itself. They only make the patient feel more comfortable during the illness, and recovery from a cold depends entirely on the body's own immune system, which has nothing to do with cold medicine. Many drugs even only serve as psychological comfort and have no real effect.

For example, hypertension and diabetes are all treated symptomatically, using drugs to control blood pressure and blood sugar, but the causes of abnormal blood pressure and blood sugar cannot be eliminated. Even the mechanism of why blood pressure and blood sugar are abnormal is not very clear at present.

Professor Zhang Zongshun admitted Sisi to the hospital for the first time, so Professor Zhang has always been concerned about her condition and would come to talk to Yang Ping from time to time to learn about her situation. Professor Zhang heard that Sisi's condition had worsened, the tumor had metastasized throughout the body, and metastases were also found in the brain stem, and they were growing diffusely, so Professor Zhang was very worried about Sisi.

Professor Zhang is already over 80 years old. It can be said that he has seen through many things and has long passed the age of being happy or sad about things.

In Yang Ping's office, he stared at Sisi's MRI images for a long time. After thinking for a long time, he said, "It can't be cut now, right?"

"No, tumors in the lungs, liver, and peritoneum can be removed, but it is meaningless to only remove tumors in these areas. It is purely for the sake of surgery. The intracranial metastasis is the key. If the intracranial tumor cannot be treated, there is no point in only treating other parts. It is just a waste of surgery and counterproductive." Yang Ping always speaks directly to Professor Zhang.

"Tumors in this area are difficult to treat. What will happen if they continue to develop?" Professor Zhang knew the consequences, but still asked another question.

Yang Ping pointed to the intracranial tumor on the image with a pencil and said: "Whether it is a ruptured and bleeding tumor, impending compression, or damage to brain cells, once the critical point is exceeded, the consequence is respiratory and heartbeat arrest, and there is no way to save it."

"It's difficult!"

"So I'm keeping her in the hospital now. If the child wasn't in the hospital, she might die someday."

"We went around in circles but ultimately didn't get around."

"Yes."

"Are there any new drugs in the field of targeted therapy that target this type of tumor? Internationally?"

Professor Zhang is an experienced expert in orthopedics and has a certain amount of knowledge in tumors. He also keeps reading the latest literature every day, but his grasp of the latest knowledge is definitely not as good as that of young people.

Targeted therapy drugs are actually developing very well now. Some tumors can be controlled through targeted therapy alone, and a few tumors can be cured by targeted therapy.

Yang Ping shook his head: "There is currently no effective targeted drug for this tumor. There are several targeted drugs in clinical use, but the treatment effect is not good. It is better than nothing."

"What about CAR-T cell therapy? Is there any progress in this area?" Professor Zhang was determined to get to the bottom of it.

CAR-T cell therapy, which costs $1.2 million per injection, can cure non-Hodgkin's lymphoma and completely eliminate tumor cells. This effect can be described as amazing in tumor treatment.

"The excellent effect of CAR-T cell therapy is limited to the treatment of non-Hodgkin's lymphoma. There is no effective treatment for other tumors." Yang Ping denied again.

"Immunotherapy? Biological therapy? Isn't there any feasible one?" Professor Zhang raised his voice.

Yang Ping still shook his head. If he had a way, he wouldn't have sat here and chatted with him for so long. He would have gone straight to the point.

Professor Zhang did not say anything else. He just looked quietly at the MRI image on the electronic screen with his eyes slightly narrowed.

He has encountered such helpless situations countless times in his decades of medical practice. This is not the first time, and it will not be the last.

"Try your best. Try your best to improve the quality of life and let the child pass away with less pain. This can be done."

Professor Zhang stood up, stretched his waist, then walked out of the doctor's office with his hands behind his back. Yang Ping watched his back, feeling a little uncomfortable.

In fact, every doctor wants to cure his or her patients, but often fails to do so.

After walking a few steps, Professor Zhang turned his head and looked into the doctor's office, and saw Zhang Lin instructing the intern on how to write medical records.

"Xiao Zhang, gather everyone together and come to the duty room to work overtime!" Professor Zhang shouted.

Zhang Lin was busy at the moment and hadn't finished explaining the medical records to the interns, so he replied, "I'm busy today, how about tomorrow?"

"What are you busying about? Hurry up and get the team over here. Let's have some fun today." Professor Zhang said in an unquestionable tone.

Zhang Lin immediately put down what he was doing and started calling people on his phone. What happened to the old man today? Why did he seem a little irritable and his words were not right?

Sisi herself was very relaxed. She no longer cared about how her condition would develop, so this time Yang Ping did not explain the condition to her. She did not ask, nor did she ask her parents about her condition. Perhaps she had become accustomed to these things after going through the same thing over and over again.

At this time, Yang Ping couldn't help but think of Luo Jin, who is now playing football in Europe. He heard that he could only save his life after the operation and could no longer play football. He gave up the operation and would rather spend the remaining time on the green field than undergo the operation. Luo Jin has experienced too many hardships since he was a child. Perhaps he has glimpsed the true meaning of life, and his thoughts are different from those of ordinary people.

Judging from some of the examination images sent back by Luo Jin, he didn't have much time left, but he didn't care.

Sisi is in the same mood now. This time she is surprisingly calm, without any anxiety or impatience, as if nothing had happened.
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When Yang Ping was worrying, good news came from Professor He. The simple and elementary model of artificial intelligence designed by their team for the laboratory was already available for use.

This model is just a small lightweight model, and they are also preparing to develop a large artificial intelligence model.

Before the large model is developed, the laboratory of Sanbo Hospital can temporarily use this small model as a transition.

This is good news. Yang Ping decided to use this artificial intelligence model immediately to screen and transform the virus. If he relied on manpower to screen and transform, it would take at least several years to find a suitable virus delivery vehicle. Now with the assistance of artificial intelligence models, this time can be greatly shortened.

Even though what Professor He has launched now is just a crude and simple model, it is still thousands of times more powerful than human power.

In the past, because of the system space as an aid, Yang Ping could carry out the entire test screening process in the system space, which could greatly save time. Now that the system space is temporarily on strike, Yang Ping can only think of a solution on his own. The best way is to use computers, especially artificial intelligence.

However, artificial intelligence models cannot be developed just by developing them; it requires a certain amount of time to accumulate technology.

However, money makes things easier. In order to develop this artificial intelligence model, Ruixing Group has spent huge sums of money to acquire several of the world's outstanding start-ups. This can save time and is much better than starting from scratch.

As Yang Ping's partner, Professor He can share the technologies acquired by Ruixing Group. Professor He's current team uses the acquired technologies to reorganize and improve them, and soon produced an artificial intelligence model that can be used immediately.

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Later they will learn from the strengths and weaknesses of these models, and then build their own new large model.

After hearing the news, Lu Xiaolu immediately took people to Professor He's Digital Medicine Laboratory at Nandu Medical University and used their models to screen and transform the virus.

In about two hours, it proposed hundreds of thousands of options for virus screening and modification, and then sorted these options, eventually selecting a dozen optimal options.

Yang Ping decided to conduct laboratory cultivation immediately after the virus screening and transformation was completed.

Yang Ping will use these special viruses directly on Sisi.

This was indeed too risky and unethical, but he had no better way and he had to race against time.

When virologist Beata Harasi used oncolytic virus therapy to treat her own triple-negative breast cancer, she was experimenting on her own body. Historically, many scientists have used their own bodies for experiments, which can save experimental time.

But Sisi is different. Once clinical trials are conducted directly on her, she and her family will definitely agree and will fully cooperate.

But society will definitely not agree, and Yang Ping will face ethical questioning, social doubts, and public opinion turmoil in the future.

If he fails, and if Sisi dies, he will most likely fall into the ethical condemnation of the entire society and end up in disgrace. In most cases, the torrent of condemnation from society is completely irrational and will not lead to in-depth thinking.

Never mind. How much is reputation worth? Compared with human life, reputation is nothing!

Yang Ping sat in his office and thought about it. When he was still an ordinary young doctor, although he worked hard, he would not have achieved what he has today without the help of the system. He went through so much learning and training, wasn't it to cure diseases and save lives? If he was timid for the sake of his own reputation, then he didn't deserve to have this system.

He no longer cared about so much, he needed speed, and Sisi didn't have time to wait.

When Yang Ping proposed to use the special virus directly on Sisi, Dean Xia, Director Han, Song Zimo, Xu Zhiliang and others all looked at him in surprise.

"This is a brand new and special virus. You used it directly on humans without any ethical review. If it causes Sisi's death, the public opinion consequences will be very serious. You must think carefully!" said Dean Xia.

"I've thought it through, and I must do this." Yang Ping said firmly.

Dean Xia paced back and forth in his office. If something went wrong, public opinion would be overwhelming. If it was exploited by certain forces, it would be like a raging flood.

By then Yang Ping will definitely be ruined!
"Would you like to consider it? Are there any other solutions?"

"I have thought it through. There is no other way."

"Do you really have to do this?"

"must!"

"Okay, I'll be the first to support you. If you're not afraid, why should I be afraid? I've been the dean for so many years and I've never done anything crazy. Now I'll work with you. I'll call a meeting on this matter. If anything goes wrong, I, Xia Changjiang, will take the brunt of it."

To this end, Yang Ping gathered everyone together and began to implement his plan.

The virus modification model demonstrated by 3D animation is suspended on the electronic screen. The K factor is embedded in the virus to form a complex protein structure. This is a brand new virus.

This is a magical virus that has been used in virtual experiments in the virtual environment of Professor He's Digital Medical Laboratory. It can carry the K factor, reach the tumor through the blood circulation, and then infect those tumor cells, and then start the apoptosis program of the tumor cells. Finally, the tumor cells die, and normal cells are not affected at all.

According to normal procedures, the ethical approval for this type of experiment is extremely strict. After the sample is produced, the next step should be animal experiments. After the animal experiments are qualified, they can enter clinical trials after passing various approvals.

Yang Ping calculated that the whole process would take about 5-10 years. How could Sisi have ten years to wait? It was unknown whether she could survive tomorrow.

Regardless of whether this plan works or not, it is the only possible method and we have to give it a try.