godfather of surgery

Chapter 1084 Suddenly enlightened

In Yang Ping's office, there were all kinds of strange pictures on the whiteboard, including the structure diagram of NK cells and the structure diagram of vector adenovirus. Yang Ping stared at the pictures in a daze, completely lost in thought. Even if the sky fell at this moment, he probably would not have any reaction.

Now he is used to thinking about problems in the office. The office has good lighting and air, and the soundproofing measures are in place. It is very quiet when the door is closed, and generally no one will disturb him. People from his department will contact him in advance via WeChat before coming to the office, and knock on the door after confirmation, instead of banging on it rashly. Everyone knows that Professor Yang is thinking about problems in his office, not doing anything else. When thinking about problems, it is most taboo to be disturbed by others. Interrupting thinking is a very annoying thing, so everyone is conscious of talking nonsense and will never disturb Professor Yang rashly, unless there is a fire or something like that, and emergency evacuation is required.

There are so many kinds of immune cells in the human body, T lymphocytes and NK cells are just one of them. Yang Ping is thinking about whether to include other immune cells in the research scope one by one, and then see which cells are easy to use and easy to accept transformation. By continuing the research in this way, a large amount of basic data on immune cell therapy can be accumulated. Regardless of whether a breakthrough success is achieved, it will lay a solid foundation for the future.

Virus therapy actually has great potential because viruses can invade the interior of human cells, which is something that immune cells cannot compare to. Immune cells are still cells after all, and are at the same level as tumor cells in terms of the biological structure hierarchy.

Viruses are one level lower than cells in the biological structure hierarchy. They are at the same level as organelles within cells. Their biggest advantage is that they are very small compared to cells and can penetrate the cell membrane and enter the interior of the cell. In theory, viruses can more easily deal with tumor cells than cells.

Viruses and cells, the biggest advantage of cells is that they are the body's own immune cells, they will not be attacked by themselves, and they have their own navigation equipment and various weapons. The biggest disadvantage is that they are at the same biological structure level as tumor cells. The biggest advantage of viruses is that they are lower than cells in the biological structure level. The biggest disadvantage is that they are always foreign objects, need to face the human immune system, and have no weapons of their own, so they must use genetic engineering technology to embed weapons.

Is it possible to combine this vector virus with immune cells, transplant fragments of antigen receptors and tumor necrosis factor on the immune cells onto the virus, and combine them into a new virus? In this way, the virus can also recognize tumor cells like immune cells, and then penetrate the tumor cells into the cells, and then release tumor necrosis factor and the like.

As he thought about it, Yang Ping suddenly realized!
Why didn’t you think of this? If this is the case, what is the need for the K factor? Why should the entire research be organized around the K factor? It is not necessary at all. The entire research will become more open.

"It is very narrow at first, but then it becomes passable. After walking a few dozen steps, it suddenly becomes open."

suddenly see the light!
Thinking of this, Yang Ping felt as if he had passed through a narrow passage and entered a suddenly open world.

K factor, why did K factor appear when Sisi's tumor cells were cultured in the laboratory? This was not a coincidence, there must be a reason. Before, Yang Ping thought about studying how to use K factor to treat tumors first, and then when he had time, he would slowly study why it appeared in the culture medium. Now Yang Ping has found the reason, he has touched the essence of things.

When Sisi's tumor cells were extracted, immune cells must have been mixed in at the same time, because the in vitro culture environment of the laboratory is tailor-made for tumor cells. These immune cells cannot survive normally in the in vitro culture medium of the laboratory, so they change in the special environment, the cells die and disintegrate, but in the process of disintegration, some fragments float in the culture medium and combine and piece together to form the K factor.

Yang Ping thought of some hypotheses about the earliest life on Earth. Some scientists believe that the earliest organic matter on Earth should be related to lightning, and it was trillions of lightning that released phosphorus compounds.

It should be about 35 to 45 billion years ago that some simple compounds necessary for life were released on Earth, laying the foundation for the birth of life later. In short, all life on Earth is likely to have originated from lightning. The pyroxene formed when lightning struck volcanic rocks contains phosphorus. Subsequently, a large amount of phosphorus accumulated in volcanic ponds and other waters, which can accelerate the formation of biological molecules.

The chemical substances in the early Earth mainly include water, ammonia, methane, etc. According to this hypothesis, it is lightning that stimulates these substances to react. In order to verify this conjecture, in the early 20s, Stanley Miller and Harold Urey of the University of Chicago conducted an experiment. They filled a closed chamber with water, injected ammonia, hydrogen and methane, and then repeatedly stimulated it with electric sparks. After a week, they detected 50 different amino acids in the contents of the chamber. There are also scientists who believe that solar particles may be the reason for stimulating the early life substances on Earth, but whether it is lightning or solar particles, they only have different excitation energies, and they all promote the formation of simple organic matter.

Isn't the formation of K factor similar to the formation of early life on Earth? It's just that compared with the formation of early organic matter on Earth, the formation of K factor is much easier. However, they are both a coincidental recombination.

Yes, this is the essence of the K factor. The more Yang Ping thought about it, the clearer it became. It was like running along a dark tunnel. He saw a ray of light, and then ran towards the light. The front became brighter and brighter, and finally, a vast and bright world appeared in front of him.

If this is the case, then the K factor must be a combination of gene fragments of human immune cells. If they are split according to their functions, the same fragments can be found in the genomes of various immune cells in the human body. Yang Ping put forward his own hypothesis.

But is it true? This requires splitting the K factor into gene fragments according to its function, and then rigorously comparing them with the genomes of various immune cells.

This is another big topic! The ideas quickly became clear, complete and mature.

Immediately contact Lin Lan and the heads of all laboratories and gather them together. Yang Ping wants to carry out a new research. The K factor is just a small thing. The reason for its formation is what is most worthy of study and is the essence of all current research.

"Song Zimo, come to my office, immediately, right now!" Yang Ping immediately called Song Zimo.

When Song Zimo heard the call, he didn't dare to delay and went to the director's office immediately. Yang Ping was leaning back in his chair, staring at the picture hanging on the whiteboard in a daze. Song Zimo went over and asked, "Professor!"

Yang Ping didn't say anything. Song Zimo was a little nervous. The professor called him in such a hurry, but now he didn't say a word. Did he make any mistakes? His mind was racing. All recent operations went smoothly without any complications, and there were no mistakes in work recently.

"professor!"

Yang Ping still didn't speak.

The beats in Song Zimo's heart were getting more and more intense.