godfather of surgery

Chapter 1122 Excellent Doctor's Physique
After the reform, Sanbo Hospital has been revitalized as never before. The directors of each department are young, energetic and passionate PhDs. They are knowledgeable and have rich clinical experience. More importantly, they have the vision of being discipline leaders in a first-class hospital.

The third animal experiment on the K protein complex for treating tumors is about to end, and the next step will be to enter the Phase I clinical trial. The entire experimental team is energized.

The last treatment brought Sisi's condition under control and bought some buffer time for the next treatment. Fortunately, during the buffer time, Yang Ping's tumor treatment project made progress.

Sisi is about to graduate from primary school and is now facing the transition to junior high school. Although her studies are quite intense, it will not delay her treatment because she has already self-taught the junior high school curriculum. Even if she takes a leave of absence now, it will not affect her grades. She has gone through the most difficult and desperate times. Is she afraid now? Not at all.

The treatment ideas for malignant tumors are actually very stable now, but the specific methods of treatment are changing. Surgery is only effective for early tumors that have not spread, because at this time the tumor cells are gathered in a group and have not yet metastasized to nearby or distant places. As long as this group of tumors is completely removed, and no artificial leakage and seeding occurs during the removal process, the tumor can be considered cured. However, once the early stage has passed, the tumor has spread, and its seeds are scattered everywhere. Each seed can use exponential division to grow into a group. Wildfires cannot burn it all, and spring breezes will blow it back to life. At this time, surgery is powerless and must be assisted by other treatment methods. Therefore, the exploration of tumor treatment focuses on "other methods." From traditional chemotherapy, radiotherapy and current targeted therapy, biological therapy, immunotherapy, cell therapy, etc.

People are afraid of cancer, but if we look at malignant tumors objectively, they are not as scary as we imagine. If they are detected, diagnosed and treated early, early tumors can be cured through surgery. The cure rate of gastrointestinal malignant tumors in Japan exceeds 80%, thanks to the strict and widespread implementation of this three-early plan.

Radiotherapy and various particle knives developed on its basis have not actually jumped out of the scope of surgical treatment. The difference is that it uses X-rays, various rays, and various particles instead of metal scalpels. In essence, it is still a variant of surgical treatment.

Targeted therapy belongs to the broad category of drug therapy. The difference is that it improves the tool of drug. Targeted therapy drugs have the ability to accurately identify tumor cells, so that they can eliminate tumor cells while avoiding damage to normal cells. This is a huge progress. Ordinary chemotherapy drugs do not have the ability to accurately identify, but cover tumor cells and normal cells. Therefore, in many cases, while killing tumor cells, it also destroys the body's remaining immune ability. Sometimes, not only does it not have a therapeutic effect, but it accelerates the collapse of the human body.

Yang Ping's experimental team was a little impatient. The Phase III animal experiment here had not yet been completed, but they brought Sisi into the hospital and began to conduct various pre-experimental examinations and recruit volunteers for the Phase I clinical trial. The experimental team wanted to enter the Phase I clinical trial as soon as possible.

For patients, especially patients like Sisi, getting effective treatment one day earlier means a little more hope, and Sisi is also happy to cooperate with them.

Yang Ping allocated the suite ward at the end of the corridor to Sisi for use, so that there was enough space to carry out the experiment and the privacy of Sisi, a loyal experimental volunteer, was protected.

After the results of various tests came out, the young doctors shook their heads and sighed, because every test report was either blue or red, and none of them were clear. A master's degree student who had just joined the experimental team glanced at his companion with disdain and said excitedly: "If everything is normal, would he still be a patient? Would he still run to the hospital? Would he still let us treat him? Let me see!"

He held a stack of medical examination reports in his hand. The more he looked at them, the happier he became, with a gleam in his eyes. This mess of data was exactly what he wanted. The more messed up it was, the more it could show the power of the treatment method.

"That's great, so many abnormal things." He couldn't help but say excitedly.

In fact, the attitude of this young master seems inhumane, but objectively speaking, this kind of person is most suitable to be a doctor. In medicine, the psychological study of surgeons has a psychological state called "bloodthirsty excitement", that is, every time they perform an operation and open the human body to see blood, this kind of person will not feel nauseous, afraid, or tired, but a natural excitement. The blood during the operation is like a natural stimulant for this kind of person. This kind of person has the best physique for a surgeon. He can perform various operations tirelessly and without boredom, and he will be very serious and able to enjoy himself.

Yang Ping is such a person. He once suspected that he had this kind of "bloodthirsty physique". Every time he encountered difficult patients and difficult operations, he actually had a strong sense of excitement, a desire to conquer the disease, and a curiosity to peek into the logic behind the disease.

He once thought that he was a pervert. The patients were suffering enough from their illness, but he had no sympathy and instead became excited. This was a perversion, an inhumane and demonic mentality. He had to restrain this perverted mentality, but the more he restrained it, the more painful it became.

He never told anyone until one day, when he could no longer bear the inner torture, he secretly told Director Han. After hearing this, Director Han's eyes lit up and he looked surprised as if he had discovered a martial arts genius with extraordinary talent.

This is the rare "bloodthirsty physique". Such people will tirelessly challenge difficult surgeries, find solutions to difficult and complicated diseases without fear of difficulty, have a strong desire to successfully treat diseases, and are crazy about the details of surgery and treatment. This is a professional paranoia physique. It is misleading to use the bloodthirsty physique. It should be said that it is a natural love for medicine.

Turns out this is positive, not negative.

This is like a natural born soldier. Once he encounters a war, he is not bored, afraid, or retreating, but his blood is boiling and he is eager to try. He thinks: Finally, the war is coming! If there is no war, he will be depressed, sad, and boring. Once he encounters a war, he will be full of energy, ready to die, and move forward bravely. He always feels that his value will be reflected in the war. His pleasure lies in constantly defeating the enemy. He is born for the team. This kind of person has a strong desire and ability to fight.

However, loving peace is positive. How can some people love war? This is a contradiction.

An older doctor next to him was very envious, wondering why he didn't have such a drive. He was also a tough guy. He had just graduated and was assigned to work in a county hospital, but grassroots hospitals lacked an academic atmosphere. He worked while taking the postgraduate entrance examination, and finally got admitted to the master's program of his ideal school. Then he worked hard and was admitted to the doctoral program of a famous medical university. However, he did not have the special physique of his junior. He did this job just to make a living, so he did not have a natural passion for surgery, but because it could support his family.

Sisi came at the right time. Although the disease was suppressed last time, the treatment effect was ultimately unstable and it has recurred again. The new treatment method must not only be effective and safe, but also have stable effects and safety. Unstable and immature treatment plans cannot be popularized because there are many uncontrollable factors.

"Isn't this a good opportunity to try out our new method?" said the excited young graduate student.

The older doctoral student said, "Do you like patients with serious conditions so much? Can you have a little sympathy?" "Compassion? I don't have time to sympathize with them. I just do my best to cure the disease. How can I have time to sympathize with the patients?" The young graduate student told the truth. That's what he thought. All he thought about was how to cure the disease. He didn't even think about sympathizing with the patient. That is not a doctor's job, but something her family should do.

"I really admire you. When you encounter a difficult patient, you are like a chicken with blood. Is it really that serious?" The older doctoral student lectured the young man.

Young didn't care about what he said, because his attention was not here at all. All his attention was now on Sisi's MRI images. Because CT carries ionizing radiation, MRI has relatively few side effects on the body. The number of follow-up examinations would be very high, and it was not appropriate to do CT scans frequently, so Yang Ping often did MRI for Sisi.

The young graduate student imitated Yang Ping and pointed at the MRI image with a pencil: "The tumor has spread again. Compared with the last examination, there are many new scattered lesions. You see, the area of ​​the original lesions has also expanded. I want to measure the number and volume of the new lesions, and I also want to measure the previous lesions."

He was very accurate, and his imitation of Yang Ping's form was somewhat similar. After viewing the MRI film, the young graduate student said excitedly: "We are going to do a big job, this is the most suitable experimental subject." Then he began to confidently describe the prospects of treatment.

Medicine is a discipline with a pessimistic color, but a good doctor must be an optimist. Only an optimist can always maintain a heart that can overcome the disease in the midst of pessimism. Otherwise, the limited passion will be consumed in endless pessimistic events. Without passion for medicine, it is impossible to become a good doctor.

Any industry, if lacking in passion, will find it difficult to make progress and breakthroughs. Even if there are any, it will be a simple mechanical and passive accumulation of experience.

Yang Ping was chatting with Sisi about her condition in the ward. Rather than chatting about her condition, it would be more like discussing a project for which Sisi was a volunteer.

The cactus that accompanied her grew up again, and it looked greener and stronger than before. Yang Ping remembered that when he first saw this pot of cactus, it was still a little big, and half of it was withered yellow, with a part of necrotic black in the yellow. At that time, the cactus looked like it was going to die. But under Sisi's careful care, the cactus not only did not die, but thrived. The yellow turned green, the black disappeared, and the missing part was filled. The sunlight from the window shone in, and the cactus looked full of vitality.

Sisi's complexion now looks much better than before, rosy like a red apple. This is the vitality that teenagers should have.

Judging from the results of animal experiments, the results of clinical experiments will not be much worse, but this is only speculation. Many drugs or treatments are very effective in animal experiments, but have poor or no effects in clinical experiments. This situation is very common because the human body's physiology, biochemistry, and immune system are different from those of experimental pigs.

This is also the reason why the investment in drug research and development is huge, because the cycle is long, the investment is large, the final success rate is very low, and huge amounts of manpower, money and time are invested, but in the end it may be all in vain.

Sisi is determined to study medicine. She is only in the sixth grade of elementary school, but she has already finished the biology textbooks for junior high school and started reading medical books on anatomy, physiology, biochemistry, etc. Although she can't understand some of them, it does not prevent her from studying now.

Now Sisi has been practicing various surgical knotting techniques with doctors, one-handed, two-handed, instrumental, and the use of various surgical instruments. Because she is young and learns things quickly, she has learned it well. As for her own condition, she doesn't care much now, anyway, she will leave it to these doctors.

Not only is she interested in these clinical knowledge, she is also very interested in medical research. She memorizes words every day and has accumulated a lot of medical words. She can become familiar with the use of various experimental instruments and equipment by following the doctors in the institute. She even tried to participate in this experiment as a researcher and volunteer. Although her medical knowledge is very immature, it does not prevent her from seriously devoting herself to the experiment.

"It's just like playing with Lego. This adenovirus is like a toy. You can replace some of its parts with parts with other functions to achieve your goal?" Sisi was drawing a blueprint of the K protein structure complex and thinking based on the knowledge she had mastered.

"Almost. In fact, any advanced knowledge is not that complicated in principle. It's very simple. What's so complicated about it? The complexity lies in the details of the structure and steps. The structure is composed of many parts and the steps are complicated. There are more details. For example, the principle of the hydrogen bomb is very simple. Not to mention high school chemistry, you all mentioned it in junior high school chemistry. It can be expressed with an equation, but to realize it, there will be many details, and these details make up complex structures and steps. It's the same as when you solve a difficult math problem. It can be solved in a simple step without any details, while a complex problem requires many steps and many details that need to be dealt with." Yang Ping tried his best to tell her in a language that she could understand.

She twirled the pencil in her hand. "I seem to understand a little bit. Structure determines function. This virus is a living organism composed of a protein shell and nucleic acid. By artificially changing its structure, it can achieve certain specific functions."

"That's right. You have a strong ability to understand and your language expression is very mature now. That's what I mean. K factor can kill tumor cells, and viruses can infect tumor cells. Put them together to form a weapon that can infect tumor cells and then kill them. This weapon needs to avoid human immunity, so some kind of escape factor is also assembled on the vector modified from adenovirus. Their combination is not a simple combination, but requires extremely high skills, just like a car. Combining the engine, frame and tires together requires technical details, rather than piling them together." Yang Ping was no longer discussing the condition with her, but the project, and he discussed the condition with the idea of ​​doing a project.

In fact, this is a good thing. This little girl is really suitable for studying medicine in the future. Her IQ and psychological quality are both top-notch. If she studies medicine, she will definitely be an excellent doctor.

"In another six years, I can enter university and study medicine formally." Sisi calculated the time on her fingers.

"I'm going to take the eight-year program at Nandu Medical University. You promised to be my advisor, and you can't regret it when the time comes." Sisi put down the pencil in her hand, her eyes full of longing for the future.

"Aren't you afraid? The experiment will fail?" Yang Ping asked.

Sisi said calmly: "My life has been saved, why should I be afraid? Don't tell me these things, you need to tell me the structure diagram, why is it assembled like this? What's the reason?"