godfather of surgery

Chapter 1128 Calmness is Compromise

One week after Sisi's second surgery, the edema in her brain tissue had completely subsided. The results of the follow-up MRI shocked Yang Ping himself. The original tumor image had shrunk by 50%. This effect was better than the original animal experiment. The best data from the animal experiment could not compare with the current clinical data.

If it weren't for the unexpected brain edema during the experiment, this experiment would have been perfect. It seems that animal experiments are sometimes very different from real volunteer experiments. Humans and experimental pigs are different in many aspects, resulting in great differences in treatment doses, effects, side effects, etc.

Yang Ping carefully analyzed the shortcomings of this experiment. The main problem was that there was too much deviation in the control of the dosage, which led to the accident in this experiment. If the dosage was controlled much less, the tumor cells in the brain would not die so quickly, and the development of brain tissue edema would be much slower, so Sisi would be much safer.

In the human body, for different tumors, the dose is related to the speed of tumor cell death. This is a major problem facing future clinical trials, which requires careful research and precise adjustment of the dosage in the later stage. In addition, more complex and cautious research will be carried out on intracranial tumors to avoid similar accidents. The consequences of this tumor tissue edema in other parts may be relatively less serious. If it occurs in the skull, it will lead to increased intracranial pressure, which will cause brain herniation and endanger life.

Sisi escaped death and gained a new life. No matter how effective this treatment is, whether the follow-up effect will be long-lasting or whether there will be a rebound, at least the condition can be relieved for a period of time. The tumors in various places have only subsided by half. This is just the result of one treatment. The risk is a bit high, and she almost lost her life because of brain hernia, but the effect is indeed good.

The subsequent re-examination results were simply like a rhythm of a cool novel. Whether it was the image performance of the MRI re-examination or the various complex tumor marker indicators, everything was getting better. The tumor image was getting smaller and smaller, comparable to medical advertisements shot with special effects technology. The curves of various tumor indicators fell faster than stocks.

"Is this a success?" Song Zimo looked stupid after being shocked by all this.

“Ah—ah—ah—”

Xu Zhiliang stuttered for a long time without uttering a single word. This kid cannot get excited, as he would easily choke on his words if he got excited. People who don't know the situation would probably want to give him the Heimlich right away.

After the language communication failed, Song Zimo and Xu Zhiliang looked at each other, then turned to look at Yang Ping at the same time.

The professor is different. He remains calm and composed at this moment, with his hands folded in front of his chest. He carefully watches the pictures playing in a loop on the electronic film reading screen, without a trace of emotion on his face.

The aura is different. A professor is a professor. Otherwise, why are there so many people in the research institute called directors, doctors, and teachers, but only Professor Yang is called a professor.

"Is this successful? Is the data okay?" Song Zimo asked again carefully.

Xu Zhiliang expressed with a longing look that he had the same problem. When he could express it with his eyes, even a word was redundant to him.

In front was an electronic film review screen hanging on the wall. Yang Ping stood in the middle, with Song Zimo and Xu Zhiliang on his left and right. With them as the core, there were dozens of people surrounding them, and everyone was waiting for Yang Ping's answer.

Although everyone knows that the tumor has basically disappeared and the tumor marker indicators have dropped significantly, everyone still hopes to get confirmation from Yang Ping. After all, this result is a bit too magical, and everyone finds it difficult to accept it and cannot distinguish between reality and illusion.

After looking at the MRI images, Yang Ping turned around and sat down in front of a computer. He wanted to look through the various test reports again.

As Yang Ping moved his position, the crowd surrounding him dispersed. When Yang Ping sat down, the crowd immediately gathered again, forming a circle from the inside to the outside.

The effect was so good that it was beyond my expectation. After one injection, the tumor cells were almost dead. Only scattered tiny lesions were left on the latest PET-CT images, and there was no accidental injury to normal cells.

If I get another shot, will it be cured? These scattered lesions will disappear.

No, it cannot be calculated in this way. If it were such a simple calculation, the entire experiment would not have to gather so many extremely smart minds to study day and night, and Sisi would not have almost sacrificed herself for the experiment.

After the first treatment, Sisi's immune system status is completely different from before the treatment. It is not known whether it is weakened or in an activated combat state. An in-depth analysis of the status of the immune system is needed.

What state the tumor cells are in now, whether this treatment method has the ability to induce escape, etc., are all unknown and need further examination.

But at least it is certain that the new K virus can easily penetrate the tumor barrier, accurately lock tumor cells, and then kill them, and can successfully penetrate the blood-brain barrier. This is the most promising tumor treatment method in the world, no doubt about it.

If Sisi waits until all the experimental analysis results come out before the next treatment, will she miss the golden treatment window? Where is the golden treatment window? Is a second treatment needed? Is it possible? How long should I wait between two treatments? Many questions emerged in Yang Ping's mind.

Don't take risks now, you should be conservative. You took risks in the first place because you had to do it to save your life. If you continue to take risks now, it is likely to destroy the current stable state.

"The therapeutic effect of the new K virus exceeds all the current tumor treatment methods in the world. We can characterize it structurally, and then conduct further research on the treatment method, dosage, side effects, course of treatment, interval time between courses of treatment, etc., and further conduct detailed research on it." Yang Ping finally spoke.

This was a success!
Everyone was excited and hugged each other to celebrate, as this was the result of countless days and nights of hard work.

"When will the second treatment be carried out? Should we press on with our victory and eliminate the last tumor lesions in one go?" Lu Xiaolu had been silent just now, but he asked immediately. He couldn't wait to start the second course of treatment.

Yang Ping shook his head. “No, don’t rush into the second experiment before the data analysis of the first experiment is completely thorough. It’s easy to get out of control. Let’s slow down a bit and be aggressive when necessary and conservative when necessary.”

"Yes, the issue of the relationship between K virus treatment and brain tissue edema is before us. If we rush into the second experiment before solving it, and if brain stem edema becomes more serious than this time, the consequences will be disastrous." Song Zimo understood Yang Ping's idea.

Tang Shun nodded: "Cell research is our strong point. We will immediately launch a project and study this issue as a sub-topic of our laboratory. After the basic medical principles of this issue are studied clearly, we will have a much better chance of success in the second experiment."

"We must be extremely cautious in clinical trials. We would rather go slow than take risks," Yang Ping told everyone.
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A single stone stirs up a thousand waves. This stone stirred up enough waves to shake the foundations of many capital tycoons in the medical field. Their decades of investment in this field will be in vain. "Why is it a headache again!"

"Is there any problem with the re-examination?"

"no problem."

“Are you sure it’s ok?”

"That's what the doctor said."

"This is the latest intelligence. We can only get some intelligence from the periphery. We can't get any intelligence from their core circle now. They have successfully developed a biological agent modified with adenovirus, which may have excellent therapeutic effects on many tumors. If it enters clinical use, most of the current drugs will be eliminated, including most of the new drug technologies we have in stock, which will be eliminated before they are released." Rolf handed over a thick stack of information.

Li Gaoyang was flipping through the materials, but he had no intention of reading any further because of his headache. He could no longer read quietly and attentively.

"Tell me what you think. My head hurts when I see these things."

"They have already conducted secret clinical trials and have begun to publicly recruit volunteers for phase I clinical trials. The progress of the matter is beyond our imagination. Our experts predict that it will take at least fifteen years for this thing to enter clinical trials, and that's assuming everything goes well. But they entered clinical trials so quickly." Rolf was furious.

Fifteen years? That's a huge discrepancy in predictions.

"We can only rely on Fujiwara no Chisei to obtain intelligence now. All the people we sent were stopped by them. No one can get into their interior, and even the outside is difficult." Rolf said in embarrassment.

"Didn't those experts say that this technology is still in the PPT stage? It will take another 15 years before it can enter clinical trials. How come we suddenly get the news that it will enter clinical trials in just a few months? Can we trust what these people say?" Li Gaoyang said angrily.

"I didn't expect that either?"

"Should we implement Plan B?" asked Li Gaoyang.

He was very hesitant now. If they continued like this, they would be buried by Yang Ping sooner or later. But if Plan B was really implemented, he was still very scared personally because his headaches had become more and more obvious recently. Although there were no problems in each checkup, he was really afraid of a relapse. If it relapsed, no one would treat him anymore. Who would not be afraid of death?

But if he continues to play like this, the entire BG company's century-old foundation may really be destroyed.

Rolf shook his head: "No!"

"why?"

"Fujiwara Chisei's only insider has obtained confirmed intelligence. He has a large number of technologies that can bypass our core patents. These technologies can replace most of our core products. He has made a will. If he dies before the age of 100, these technical data will automatically spread throughout the Internet and anyone can obtain them at will."

"One hundred years old? You mean, his hundred-year-old will is true? Not a rumor." Li Gaoyang thought this was very humorous, but not funny at all.

"It's true! This informant stole a piece of information. We studied the information. If any pharmaceutical factory on Earth gets this information, they can produce a cheap drug that can replace one of our current best-selling products. The effect will be better than ours, and the price is only one-tenth of ours. So, his 100-year-old will is true. I used to suspect that he was bluffing, but from this stolen intelligence, it is absolutely true. If we maintain the status quo, we still have some time to deal with it. The worst result is that we lose part of the market. If we implement Plan B, we will collapse instantly. No one will doubt this."

"What a genius, it's a pity that he can't serve us. What a pity. Why is this happening?"

"He is indeed a genius. All our scientists put together cannot compare to him. I don't understand why he can't serve us. My conditions can be infinitely high. Money, reputation, status, beautiful women, whatever you want, we will give you. There is nothing that our BG company cannot do, but he has no interest in these things at all."

"Then implement Plan C and start with the people around him. He always has weaknesses."

"No, not to mention that they have tight security now, he also has a secret file. As long as anything happens to his family, he will release the information. Different amounts of information will be released according to different degrees."

"Really?"

"Once, his family member fell down the stairs and rolled, severely spraining his waist. A piece of information was released, one of our products was replaced, and the stock price plummeted. So this is not a rumor or a threat. He really has the ability to do this. It is said that he did not do this just because he did not want to disrupt the current global pharmaceutical landscape. Once the landscape is disrupted, the entire innovation system will be destroyed, the pharmaceutical industry will be in chaos, and the innovation capacity of the pharmaceutical field will be seriously affected."

"It seems that our Plan B and Plan C are invalid. We can only lock them in the safe. We can only forcefully implement Plan A and try to get some cooperation?"

"That's right, because he has no intention of destroying the existing medical system, at least not now. He knows very well the dire consequences of doing so, so we should not do such a stupid thing and force him to destroy us. Now things are very simple. If we continue to be his enemy, we may be destroyed, and others will benefit in the end. If we limit the relationship to the scope of commercial competition, we will at most have one more giant rival. Comparing the two, it is obvious that the latter is more in our interests. This is the result of the research of the strategic experts at our group headquarters, and the final opinion is to strive for some cooperation within the scope of commercial competition."

Li Gaoyang rubbed his temples. "This is a rational and far-sighted suggestion. I don't want the company to be destroyed. Besides, it's still unknown whether we have the ability to eliminate our competitors. Taking the risk of being destroyed to do something uncertain, our other competitors will be the ones laughing in the dark. It seems that I have to compromise, get along with him, meet these challenges, and solve the problems through negotiation and bargaining."

"That's right. Staying calm means compromising. Limiting the struggle to the business scope and not escalating it is the best option. It is the option that maximizes BG's interests because we are facing an unprecedented opponent. His strength is beyond our imagination, and his way of thinking is unpredictable."

"Okay, I accept this suggestion. It seems that I need to give the review images to Professor Yang for review." Li Gaoyang's fingers never left his temple.