godfather of surgery

Chapter 1132 Donations Must Be Queued
Since Luo Jin's parents were so supportive, Yang Ping decided to give it a try.

In Luo Jin's current situation, there is no way to think in a conventional way. If he doesn't get treatment, there is no chance. If he gets treatment, there is still a chance. So there is no need to consider any risks and he can directly start with the new K virus therapy.

However, the dosage needs to be calculated accurately to avoid accidents like Sisi's.

With Sisi's experience, Yang Ping already had a general understanding of the dosage. After studying Sisi's treatment data, the experimental team gained some experience, which was just right for Luo Jin.

In fact, the data obtained from these actual combat operations are the most valuable and more meaningful than those obtained from step-by-step clinical trials, because they are directly derived from the accumulation of treatment experience in clinical trials and are completely close to real clinical practice.

The dose given to Luo Jin this time was one-fifth of Sisi's dose at that time. The dose was gradually upgraded, and observation was carried out during treatment. If the effect was not good, the dose was increased little by little to avoid severe intracranial brain tissue edema caused by the rapid death of tumor cells. The side effects that occurred in Sisi must never happen again.

After the injection of biological agent K, Luo Jin developed a low fever, which was an expected immune response. Compared with Sisi's previous reaction, it was very mild. This shows how much Sisi contributed to this experiment at that time. It is no exaggeration to say that if there was no Sisi's experiment, and if the clinical procedures were followed step by step, these valuable data would have been obtained much later.

Apart from a low-grade fever, Luo Jin did not experience any other complications. On the fourth day, Luo Jin's body temperature returned to normal, indicating that the immune side effects had been overcome. The next step was to see how the edema caused by the death of tumor cells in the brain would develop.

Is one-fifth of the dose far from enough or is it an excess? Will an insufficient first dose cause immune resistance and interfere with subsequent treatment? These are all unresolved questions that need to be answered by Luo Jin.

On the fifth day, Luo Jin developed symptoms of epilepsy. This was a new discovery as it had never happened to Sisi before. The so-called epilepsy is actually caused by abnormal discharges in the brain, which means that there were abnormal discharges inside Luo Jin's brain.

Where do these abnormal discharges come from? Could it be that scarring of the brain tissue occurred so quickly? No, it can't be that fast.

If no scar is formed, the precursor of scar, granulation tissue, may be formed, which can also cause epilepsy.

Now, compared to life, these are minor problems. The clinicians involved in the experiment recalled the previous successful experience in rescuing rabies patients and put Luo Jin's brain into hibernation to reduce the damage to brain cells caused by brain tissue edema.

All of this is flawless in theory, but whether it will be effective is still unknown.

Luo Jin's brainstem respiratory center is in a suppressed state. During the treatment, even mild edema may cause respiratory arrest. This is different from Sisi, who did not have such severe respiratory depression before treatment.

A large high-definition screen is set up in the ICU office, and various data from all directions are summarized here. Yang Ping stares at the various data on the screen, hoping to explore the internal connections and make some predictions about the development trend of the disease.

"Is epilepsy okay?" asked the ICU director.

"In fact, the current treatment is somewhat similar to the rabies patients we rescued at that time, but the current treatment does not cause as much damage to brain cells as the rabies virus. Now our K virus will kill tumor cells and has no effect on normal cells. However, dead tumor cells will bring a series of problems, such as edema. We use hibernation therapy to put the brain into a dormant state temporarily. This is a wonderful method that can help the brain survive this dangerous period, but how can it cause epilepsy? What exactly causes the abnormal discharge of brain cells?" Yang Ping said to himself.

Everyone was listening attentively. Professor Yang's analysis of the condition was always like peeling off silk threads from an onion, and the entire reasoning process was flawless.

"Although this symptom is insignificant and will not cause any life-threatening consequences, we must find the cause and try to avoid permanent epilepsy after treatment."

"Could it be that the tumor cells absorb slowly, causing fresh granulation tissue to form in the brain tissue?" Song Zimo asked.

"It is possible. This situation did not occur in Sisi, but it occurred in Luo Jin. Sisi is a teenager, and Luo Jin is an adult. Sisi's tissue repair ability is stronger than Luo Jin's. The same tumor cell necrosis, Sisi's will not form granulation tissue, but Luo Jin will? This can be speculated, but why did Sisi have enhanced memory after treatment? Is there any connection between the two? Does memory enhancement mean that the synaptic connection between brain cells is strengthened?" Yang Ping asked a series of questions.

There are so many problems here, just grab a handful and they'll be piled up, and he wants to clarify every one of them.

"Our animal experiments did not take these into account. Future animal experiments will include studies on the effects of treatment on the synaptic connections of brain cells, the pathological process of tumor cell absorption in brain tissue, and so on."

"Okay, write it down!"

Tang Shun and Lu Xiaolu wrote it down immediately. After Professor Yang's reminder, they seemed to realize that this topic could be expanded and many sub-topics could be derived.

Tang Shun met Yang Ping in the plastic surgery department that day, but Song Zimo spoke before he could even open his mouth. Later, because of Luo Jin's matter, Yang Ping and Song Zimo rushed back to the department, and Tang Shun never had a chance to speak.

After completing the discussion of Luo Jin's case, Tang Shun finally seized the opportunity to report to Yang Ping on the recruitment of volunteers for the K virus therapy. Now, all 120 volunteers for the Phase I clinical trial have arrived, and they are organized and disciplined. There is no need for the institute to manage these volunteer teams.

Tang Shun now understands one thing: some people of all kinds in society can sometimes play a big role if used properly. Although these people are from the market, they just want to make money and have no bad intentions, so they can be used for cooperation.

Now that the volunteer team has been established, Yang Ping decided to start the Phase I clinical trial as soon as possible after Luo Jin's treatment is completed without any further delay.

Tang Shun meant that it was possible to set up a clinical trial department to standardize the management of clinical trials. After a detailed discussion with Manager Yang, he felt that the recruitment of volunteers was not as simple as he imagined. Once an announcement was posted online, volunteers would come to sign up on their own initiative. Previously, after the announcement was posted for several months, only a few volunteers signed up, and they were not qualified. Manager Yang recruited 200 qualified volunteers in just one day. Therefore, the recruitment of volunteers is also a highly professional matter.

Yang Ping readily agreed to Tang Shun's proposal. However, the clinical experiment department needed coordination among the institute's clinical wards, laboratories and hospital leadership before it could be established. This involved some ethical issues, so Tang Shun came to Yang Ping. Yang Ping told him to go ahead and do it, and he would communicate with the hospital.

The Clinical Trial Department will set up a recruitment department to recruit qualified clinical trial volunteers. Phase I, II, and III clinical trials all require their own recruitment of volunteers. By the IV clinical trial, biological agents have been launched on the market. The main work of clinical trials is to conduct large-scale clinical observations, so standardized clinical trial recruitment management is very important. Now many clinical trials are outsourced to makeshift teams. Manager Yang is actually such a makeshift team. Tang Shun wants to train Manager Yang well and let him take charge of the recruitment work.

Over the next few days, Luo Jin's epileptic seizures became less and less frequent. Hibernation therapy is very effective in protecting the brain, and the dosage this time is obviously more appropriate. Edema is suppressed to a relatively low level. The speed and rhythm of the process of tumor cell death - edema - absorption are also well controlled, and no catastrophic consequences are caused.

Through imaging and biochemical monitoring, Luo Jin's tumor cells have begun to die in large numbers. It seems that the new K virus therapy is indeed effective. Ten days later, Luo Jin woke up. Although he was still dependent on the machine, at least he had hope of getting off the machine.

"It went in, I finally scored." Luo Jin woke up, blinked his eyes, stared at Yang Ping and said. He couldn't have been playing football during his coma. Yang Ping shone a small flashlight into his eyes. The pupils were round and big, and the light reflection was normal. He had survived the gates of hell.

Luo Jin had just woken up and said only this sentence. Then he said nothing more. He just rolled his eyes and stared at everyone with an obvious hint of fear in his eyes.

"What's the score?" he blurted out again.

"One to zero, we won." Yang Ping followed his words.

"Really?"

Especially when he talks about football, his eyes light up.

"Of course it's true. We pulled you over, so we got one point. The other side didn't pull you over, so we lost one point. It's not one to zero, so what do you think the score is?" Yang Ping looked very serious.

"Where am I? Why am I lying here? Who are you? Oh! Professor Yang, I recognized you." Luo Jin finally figured out the situation.

Before fainting, he was on the green field in Europe, and after waking up, he was on a hospital bed in China. This switch in time and space was like a sleepwalker waking up. He was unable to enter reality all of a sudden, so it was normal to be confused for a while.

"You are now lying on the hospital bed in Sanbo Hospital. You collapsed on the court due to an intracranial tumor. Your parents sent you back. We used the latest methods to treat you. Your condition has improved now. It has been 10 days since you fainted." Yang Ping told him to see his brain reaction in order to make a preliminary judgment on certain functions of his brain.

"I can remember a little, but I didn't expect it to be so long." He finally sorted out the memories in his brain and realized his current situation.

"Thank you, Professor Yang. Did I have the surgery?"

"No, you have missed the opportunity for surgery, but we are researching a new tumor treatment method, which is still in the experimental stage. It is just right for you to use it. Unexpectedly, the effect is quite good. Now many tumor cells in your body have been killed, and the results are still expanding. It should be no problem for you to stay alive. We are confident that we can maintain the record of one to zero."

“Will you still be able to play football in the future?”

“If it can achieve the expected effect, yes!”

This experiment is a big step forward from the previous one. The team continues to summarize and analyze the data, and then improves the next experiment to make the new treatment plan more and more perfect.

Luo Jin's parents, who were waiting outside the ICU, hugged each other excitedly when they heard the good news.

"Professor Yang, if it weren't for you, Luo Jin would have been..." Luo Jin's father held Yang Ping's hand and said excitedly. He recalled that his son had repeatedly told him in advance that if he fell ill one day, he must not think about anything else and must be transferred back to China Sanbo Hospital, no matter how great the risk was.

With these words, Luo Jin's parents would transfer Luo Jin back regardless of everything. If Luo Jin had not given their instructions in advance, they would never dare to transfer Luo Jin back and would definitely stay in Europe to continue treatment. Now it seems that this choice was so correct, life and death just depended on that one thought.

"He should be able to be transferred back to the general ward in a few days. I'm not sure if he can be cured, because this is a new treatment method. There are not many cases at present. Luo Jin is the second case, but judging from the current situation, there will be no problem in alleviating the condition. In fact, the condition has been significantly alleviated now. Many tumor cells have been killed. The specific test data has not yet come out." Yang Ping always speaks so calmly and rationally. People who are not familiar with him will definitely think that this doctor is very indifferent.

"Thank you, thank you so much!" Luo Jin's parents said while wiping away tears.
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America at this time.

"They have successfully treated another case that is more serious than yours."

Rolf said excitedly.

"Donate money for me, please help me contact Professor Yang's foundation as soon as possible, and donate money. I want to donate money." Li Gaoyang could no longer wait, he decided to resign from the position of chairman of BG Company and focus on his treatment.

"I have actively contacted Professor Yang's research foundation for you, but you have to queue up to donate. There are too many people donating to them, and they have to strictly review the qualifications of donors." Rolf is already trying his best.

“Do I need to queue up to donate? Do I need to verify my qualifications when donating?”

Li Gaoyang had never heard of such a strange thing. Even if you send money, you may not be eligible? And you have to queue up.

"There's no way. You're not the only one who wants to donate. Especially after their stem cell technology was announced, many people wanted to donate in the hope of obtaining qualifications for experimental treatment. I predict the same will be true for their new tumor treatment method now. Once it is announced to the public, many people will scramble for qualifications for experimental treatment. So we have to act quickly and complete the donation and obtain volunteer qualifications before their paper comes out." Rolf said helplessly.

"Increase the donation amount, no matter the cost." Li Gaoyang said gritting his teeth.

"It's useless. You can improve, but others can't? And when the money reaches a certain amount, the amount is no longer that important." Rolf said.

"There is also a biggest obstacle. The volunteers for the Phase I and Phase II clinical trials are limited to Chinese, and only the Phase III clinical trials begin to recruit foreigners," Rolf added.

"How long will it take?"

"I don't know either."