godfather of surgery

Chapter 1156 Micromachines
"Just watching for fun," the girl said nonchalantly.

Actually, she wanted to accumulate some knowledge about marriage and relationships. She was usually busy studying and working in the lab, so her knowledge of marriage and relationships was completely blank. Her relatives kept urging her to get married every year, making her feel like a shrew.

Therefore, she wanted to accumulate some knowledge about marriage and relationships, so she started with psychology, zoology, and other fields. She believes that humans are first and foremost animals, so the logic behind their behavior cannot be separated from some animal attributes. Furthermore, humans are higher animals with a spiritual world, so it is necessary to accumulate some knowledge of psychology.

“I think she’s absolutely right,” the PhD student who had just offered his opinion said immediately.

"I have noted down your suggestion. Please submit the review to me as soon as possible. If anyone else has any comments, please feel free to speak up."

When everyone saw the PhD student's suggestion, Professor Yang took it very seriously and then began to offer their own opinions. Many of these opinions were indeed very valuable, and these were issues that could only be discovered by those who have been on the front lines of scientific research for a long time.

After the excitement subsided, Professor Lin Lan still remembered the matter of scientific mathematical models: "Professor Yang, please remember to have your Professor Lu come and give us a lecture."

Yang Ping turned to look at Xiao Wu: "Is everything alright?"

Xiao Wu was bursting with confidence: "No problem! I'll schedule a time with Dr. Wen later."

"Xiao Wen, remember to schedule a time with Professor Lu," Lin Lan instructed her secretary, Dr. Wen.

Xiao Wu never expected that the knowledge he had accumulated from listening to Professor Yang's lectures would be so valuable. At the time, because he didn't understand the lecture, which involved a lot of mathematical knowledge, Xiao Wu spent a lot of time reading math books before finally understanding the mathematical model of uncertainty asymptotic progression proposed by Professor Yang. It is actually a dynamic optimal form.

By utilizing mathematical probability, it does not concern itself with the specific data of the experimental results, but only with the deviation between the results and the expectations. This allows for the selection of the best option among multiple routes for the next step. After multiple optimizations and superpositions, the success rate of the experiment is greatly increased.

In the investment field, quantitative trading is a typical example of this probabilistic prediction model, which uses mathematical models to make decisions and select investment targets on behalf of humans.

The world's highest-earning mathematician is Jim Simons from the United States. He is the pioneer of quantitative trading, having applied mathematical models and algorithms to the financial markets and reaped enormous profits.

Yang Ping is now trying to establish such a mathematical model and algorithm in the field of scientific research to guide scientific research in the right direction, save time and reduce waste. The optimization method he proposed earlier is the prototype and mathematical principle of this quantitative model.

Xiao Wu and Zhang Lin were usually at the bottom of the molecular biology research institute, so they always felt bad about themselves. They studied very hard and now they have discovered that they have a good grasp of the knowledge, which is also at the forefront of scientific research methods in the world, so their self-confidence has greatly increased.

It was getting late, and Yang Ping, along with Zhang Lin and Xiao Wu, were preparing to head back when Pan Xiaofei, the director of the Physiology Department, rushed over to find him. Yang Ping asked what was so urgent, and Pan Xiaofei explained that they were working on a research project using mice as a model to study cardiac function, and they were facing a major problem: they kept failing to insert a cannula into the mice's hearts, having failed more than ten times already. He had heard that Professor Yang from Sanbo Hospital was there, and he wondered if he could ask Professor Yang's doctor for help with the cannulation, as surgeons are known for their dexterity.

"You're using mice as a model for your research on heart function?" Yang Ping asked, because such research usually uses pigs as the research subject. Pig hearts are about the same size as human hearts, and many parameters are similar. In addition, pigs are easier to manipulate for experiments. Mouse hearts are so small that they are not suitable for research on the heart.

Director Pan said, "I used to use laboratory pigs for experiments. Indeed, the parameters of laboratory pigs are close to those of humans. However, there are also drawbacks. Each experiment requires a lot of people. Using mice is a smaller experiment, but it is more convenient. One person can operate them. Wearing protective gloves, one can reach into the mouse cage, grab the mouse, and fix it on the board. One can do whatever one wants with it. A pig requires several people to cooperate. Using mice saves both money and effort."

“One of the current challenges is to connect a machine to several major blood vessels in the hearts of mice and test various parameters supported by the machine. The project has been stuck at this stage and can’t move forward because none of us can perform the intubation step. We plan to ask the affiliated hospital for help from clinicians. Today, I heard from my colleagues that Professor Yang brought two doctors here. I was thinking if we could ask you to help teach us how to intubate,” Director Pan said with difficulty.

"Come on, I'll go take a look." Since someone has come to ask for my help, I should naturally offer it.

Led by Director Pan, everyone moved to the laboratory of the Physiology Department. Several female PhDs were engrossed in performing some kind of operation under the microscope. When they heard someone come in, they immediately stopped what they were doing. They saw Yang Ping and thought he had come to check on their work, so they stood up nervously.

Yang Ping never liked doing inspection work, so things came as a bit of a surprise.

Yang Ping glanced at the lab table. Under the microscope lay a bloody mouse, and the female PhD student was still wearing her gloves.

"They are inserting cannulas into the hearts of mice," Director Pan explained.

Then he turned to the female PhD student and said, "Xiao Li, how did it go? Did you succeed?"

Xiao Li shook his head.

This little white mouse is quite small, all red, smooth and hairless, only the size of a little finger. Could it be an infant white mouse?

"Isn't it a lab mouse? Why is it so small?" Zhang Lin peered over.

"Its skin is still red, and it doesn't have any hair on its body. What breed is it?" Xiao Wu asked, puzzled.

Director Pan said somewhat embarrassedly, "Our research project studies the various physiological changes in the hearts of newborn mice under extracorporeal circulation. These mice are newly born, so they are a bit small."

No wonder the intubation failed dozens of times. It's not guaranteed to succeed even if you investigate from the beginning to the end of the year. These clumsy female PhDs have no surgical training or experience operating under a microscope. How could they possibly succeed in intubation? How many newborn guinea pigs would be sacrificed?

"I heard that you have specialized training under microscopes, and one of the training contents is to attach tails to newborn mice, so I would like to trouble you to see if you can insert a few tubes and make a few models." Director Pan chuckled.

"Why don't you use piglets? Using piglets would save you so much trouble," one of the professors following behind asked again.

Dr. Li pouted and said, "We are now innovating by conducting micro-experiments, which reduces the experimental space, equipment, number of people, and funds, thus saving a lot of resources."

The female PhD student was quite pretty and had a pleasant voice. The male PhD students who came with her started to drool over her. They had no idea there was such a beauty in the physiology department. Everyone squeezed in.

There are indeed very few female PhDs in science fields. There are slightly more female PhDs in medicine than in other science fields, but they are still pitifully few. The male-to-female ratio is seriously imbalanced, otherwise that PhD wouldn't have raised such a serious question just now.

"You use such small white mice as models, do you have such small ECMO machines?" Yang Ping was very curious. A real ECMO machine costs tens of millions of yuan. If you were to completely replicate a miniature ECMO machine, you can imagine how much money it would cost. Even if you had the money, you couldn't replicate it.

It's not about making a model, but replicating a miniature Boeing passenger plane. This is hundreds of times more difficult than manufacturing a Boeing passenger plane because it requires manufacturing such a small engine and miniaturizing all the parts.

“We have a mini ECMO machine,” Director Pan said proudly. “Xiao Li, take it out and show it to everyone.”

This machine is the prized possession of the Physiology Department.

Really?
Dr. Li immediately took off his gloves and took out a miniature machine from the cabinet, about the size of a dictionary. Director Pan gave Yang Ping a pair of gloves, which Yang Ping put on and took the miniature ECMO. The device was very exquisite, just like the real thing.

“Professor Yang, this is not a model, it’s a real machine. It can be used normally and its internal structure is similar to that of a real ECMO,” Dr. Li said.

“We not only have miniature ECMO machines, but also miniature extracorporeal circulation machines, anesthesia machines, and so on. So we have the conditions to conduct miniature experiments. It’s just that inserting a cannula into the heart of a mouse is really too difficult. My eyes are all red, and I haven’t succeeded even once. Either I can’t insert it, or I puncture a blood vessel.” Dr. Li’s eyes were indeed a little red.

"Have you received any training in operating a microscope?" Yang Ping asked her.

She shook her head: "No!"

Yang Ping placed each of these miniature machines under a microscope to examine them, and then had Dr. Li demonstrate their operation. These weren't toys; they were genuine miniature machines. Where did these machines come from? If many experimental devices could be miniaturized or micronized in the future, many experiments could indeed be miniaturized. Dr. Li's idea was excellent and very creative.

"Director Pan, who proposed the miniaturization experiment in your teaching and research department?" Yang Ping wanted to know the answer.

Director Pan pointed to Dr. Li and said, "That's Dr. Li."

"Where did you purchase these machines? The technology behind these machines is quite advanced. I roughly estimate that these miniature devices are worth over 100 million yuan," Yang Ping said.

Director Pan was immediately shocked: "No way, these little things are so valuable."

Then Director Pan looked at Dr. Li, who was also very surprised: "Over 100 million? Impossible, this thing is just a toy."

“A standard ECMO machine costs over a million yuan, and an advanced version costs around three million yuan. Even if your miniature machine has undergone many simplifications in its internal structure, it is still highly technologically advanced and worth no less than thirty million yuan. Adding those other machines, it really has exceeded one hundred million yuan,” Yang Ping said. He was very curious to know where these machines were purchased from.

"Where were these machines purchased?" Yang Ping asked.

Dr. Li hesitated for a long time, her face turning red, as if she was embarrassed to speak.

Director Pan answered for her: "This was given to Xiao Li by her boyfriend. She donated it to our teaching and research office free of charge. She suggested trying to do micro-experiments, which are experiments that previously had to be done with large animals. With the help of these machines, we can use mice instead. I think this is a good idea, so I want to give it a try."

"Yes, my boyfriend gave it to me to play with. He said I could use it for experiments if I needed it, and if I didn't need it, I could use it as a toy. I didn't expect it to be so expensive. I don't know where he got it from. I really didn't know it was so expensive." Dr. Li looked very scared, as if he had done something terrible.

Sigh, she has a boyfriend, and he seems to be quite wealthy. The male PhD students around her began to sigh; they had just seen a glimmer of hope, but now it had been extinguished.

"Your boyfriend? Could you please ask him where he got the machines? As far as I know, there aren't any miniature machines like this on the market." Yang Ping was very interested in this and was determined to find out where these machines came from.

If these machines were to be 100% copied from the original, only scaled down, the technical requirements would be extremely high. If the internal structure were simplified while achieving the same effect, the technical requirements would be even higher.

Dr. Li looked outside: "He—he's waiting for me to get off work in the next office. I—I'll call him over. Professor Yang, can you just ask him directly?"

"If it's convenient, please ask him to come over," Yang Ping said politely.

Dr. Li immediately said, "Convenient, convenient, very convenient."

Dr. Li is the naive and innocent type, very simple-minded. Now that she heard these machines cost over 100 million, she's terrified. Her boyfriend had only said that he liked making these toys, so he made a lot of them. He heard they needed these machines for their experiments, so he gave her a few to play with. Now that these toys cost over 100 million, it really terrified her. She received a gift from her boyfriend worth hundreds of millions; how could she accept this?

Furthermore, now that Professor Yang is asking this question, she doesn't know why he cares so much about these machines, so she is even more afraid.

"I'll go get him. My boyfriend is a very nice guy, you can ask him anything." Dr. Li hurriedly went out.

A few minutes later, she brought over a young man. Yang Ping recognized him as Chen Zhi, the chief engineer of Ruixing Group.
"Professor Yang?" Chen Zhi was also stunned, then looked at the large group of people.

Did his girlfriend get into trouble and get criticized?

“Chen Zhi, tell Professor Yang where these miniature machines you gave me came from. Professor Yang just asked that question.” Dr. Li tugged at Chen Zhi’s clothes.

"Professor Yang! Hello!" Chen Zhi immediately shook hands with Yang Ping.

"Chen Zhi? Is this your girlfriend?" Yang Ping smiled and took Chen Zhi's hand.

Chen Zhi nodded: "Yes, these machines are what I tinkered with in our lab when I had nothing else to do."

"Look, Professor Yang, this ECMO machine is one I redesigned. It has half the number of parts as the ECMO machines currently on the market, while maintaining the same performance. As a result, its stability, reliability, and durability have been improved several times over, and the cost and size have also been reduced significantly. Our company is now preparing to conduct trial production of the machine." Chen Zhi picked up the miniature ECMO machine.

"At the time, I heard that Li Yue had the idea of ​​doing miniature experiments. She was afraid of using experimental pigs every time she did experiments, so she wanted to use mice. But where could I find a machine small enough to support mouse experiments? So I decided to make one myself. But I found that many ECMO parts simply couldn't be miniaturized. In order to shrink the machine, I modified the machine structure and simplified many parts. I didn't expect that I could actually make it." Chen Zhi explained to Yang Ping.

Chen Zhi is indeed a genius; no wonder Huang Jiacai values ​​him so highly.

"You two know each other?" Dr. Li was dumbfounded.

“Of course I know him. This is Professor Yang. We meet often,” Chen Zhi said.

Yang Ping smiled and said, "This is Ruixing's chief engineer. Many of the experimental instruments in our laboratory were made by him."

"You—you are Ruixing's chief engineer?"

Li Yue could hardly believe it. Didn't he say he was just an ordinary engineer?
The boys who were eyeing Dr. Li immediately backed down. They had heard that Ruixing's chief engineer earned over 100 million yuan a year, making him a self-made millionaire, and he was also quite young, only around thirty years old.