It's not that hard to open a hospital in another world, right?
Chapter 1021 The first vaccine, Gretel, do you want to try it yourself?
Chapter 1021 The first vaccine, Gretel, do you want to try it yourself?
One group was screened for weakly virulent strains.
One group did research on vaccine production methods.
A group of people did research on vaccine storage methods.
One group is doing research on vaccination methods... The experimental group uses [epidemic technique] to urge the virus strain to be vaccinated, and the control group uses the injection method to urge the virus strain to be vaccinated.
The 20 plague mages, as well as the mages who were already in the research institute, were driven to death by Gretel.Just saving the vaccine exhausted the energy of that group of magicians:
"Dissolve the vaccine in distilled water!"
"Dissolve the vaccine with sterile saline!"
"Use 0.5%, 1%, 2%, ... 5% glycerin solution to dissolve the vaccine!"
“用5%蔗糖水溶液、5%蔗糖脱脂乳液、1. 5%明胶水溶液、1.5%玉米淀粉液……”
"Store at room temperature, store at 1 degrees above zero, store at zero temperature, store at -4 to 20 degrees below zero, store at -70 degrees, and freeze-dry at -[-] degrees!"
"Save for one day, 5 days, 15 days, 30 days... half a year, a year!"
"All combinations, all done again!"
The point is, it’s not just done.After the time is up, the preserved vaccine must be taken out to be thawed, diluted, and then injected into the mice again.Then observe the condition of the mice, whether they are sick, whether they have acquired immunity...
"Did you drill them too much?"
Seeing Gretel page by page, flipping through the reports handed in by each group, Archmage Hines couldn't help complaining:
"Even if you don't know exactly what to do, at least you have a general idea! Now that you're like this, are you letting them try combinations one by one until they die?"
"I just don't know how to do it!"
Gretel spread his hands confidently:
"I know how to do it. I just started. What do you want them to do? I just don't know, so I want them to try one by one! Don't worry, when they make other vaccines next time, they will have these plans anyway, and they can do it." Take it out and try again..."
"..."
"..."
No matter how Gretel squeezed his labor force, the research and development of the live attenuated yellow fever virus vaccine finally produced little by little results.Stable attenuated strain, successfully passed the test of 5 consecutive generations of transmission, the virus is genetically stable, and there is no sudden increase in virulence;
Research on vaccine production methods, using 7-day-old chicken embryos to inoculate the strain in the yolk sac, cultivating at 37.5°C~38°C after inoculation, and harvesting within 70~80 hours. With sufficient and stable egg supply and low price, it has defeated small vaccines. rat group and rabbit group;
(What? Cell group? Sorry, the cell group still failed to feed the cells and missed the competition)
For the vaccine preservation group, the optimum plan for harvesting the chicken embryos and storing them at -40°C, aspirating the liquid to confirm the sterility, grinding, centrifuging, and freeze-drying and sealing was determined;
As for the vaccination group...
"At present, it seems that the experimental group is inoculated quickly and efficiently, but the disadvantage is that the inoculation effect is unstable." Grete flipped through the experimental records in his hand—the experimental records of inoculating mice, and discussed with Archmage Hines and others. :
"It may be the reason [Plague Art] needs to be manipulated by a magician. Different magicians have different spellcasting strengths; even the same magician, affected by mood and manipulation level, the intensity of each spellcasting will be different."
This difference in intensity, so far, has not affected the protective efficacy of the vaccine—obviously, [Epidemiology] can be triggered, and there is still a lower limit for its strength—however, it has affected its safety:
"Among every 100 mice vaccinated with [Epidemiology], there is an average of 1 case of adverse reactions - including but not limited to redness and swelling at the injection site, pain, poor food intake, fatigue, moderate fever, nausea, vomiting, diarrhea, Convulsions etc."
"Please, this is the plague spell!" Archmage Haines sneered:
"What result do you want? It's just a little uncomfortable, which is already very mild compared to death."
"But the control group—that is, the group injected with syringes, is much safer." Grete turned the information in his hand to another page:
"So far, the adverse reaction rate is less than one in a thousand. In terms of the safety of the vaccine, injecting it with a syringe is a better method."
"But the syringe is too troublesome." Lynn said softly on Gretel's right.In this project, he followed Gretel from beginning to end, sucking, injecting, sucking, injecting, and dealing with syringes, he was almost vomiting:
"It's a very troublesome thing to sterilize so many needles every day... It doesn't matter in the research institute. I don't think everyone will sterilize the tens of millions of natives down the mountain..."
"This is the trouble." Gretel nodded slightly.In this world, no one knows better than him what will happen if the syringes and needles are not properly sterilized——
In the world before traveling, even with the widespread barefoot doctors, even with the productivity of the 80s and [-]s, vaccinations in mountain villages, there are still some places that are not strictly sterilized...
The result is widespread cross-infection.In a village, if one person gets hepatitis B or something, it will often lead to the recruitment of the whole village...
At that time, the level of productivity and personnel training were still the same. In this world full of natives, Grete did not dare to think about it.
"Using a syringe will cause widespread infection...a disease in one person will spread to everyone..."
"Then what do you want?" Archmage Hines frowned.Gretel turned his face and stared into his eyes expectantly, his face full of reason:
"I would like you to try it out, develop an inoculation device! Carve out the spell model, put the standard-strength magic crystal energy in it, and put the poisonous seeds in it—"
He made gestures and pressed down with his hand:
"Crack! The output is stable, the range is stable, and the adverse reaction rate is controlled in an extremely low range... Isn't this very good?"
"..."
That's good, but why did this kind of change matter come to me?
Archmage Hines wanted to complain very much.However, under Gretel's expectant eyes, he still mumbled in response:
"Okay, I'll do the job. It's also a necromantic spell, so digging a little deeper won't bother me... Shall I start now?"
"We have to wait a little longer." Gretel smiled:
"The vaccine needs to be tested on monkeys. If there is no problem with monkeys, it will be tested for safety on humans. After the safety is confirmed, the effectiveness will be determined, and then large-scale vaccination will be carried out. In the last stage, it is the test of epidemic disease that will contribute. opportunity……"
"Wait!" Archmage Hines looked at Gretel warily:
"Try it on people? You won't be the first to try it on yourself? ——I warn you, if you dare to do this, I will take you back to see your teacher..."
If it was in his previous life, Gretel, who followed in the footsteps of his predecessors, might have really injected himself with the first vaccine.But now, he just spread his hands:
"My physique is at least at the level of a knight. Hey... If you hit me, the reaction will be very small, and the safety test is inaccurate!"
According to what you said, if you weren't physically strong enough, would you really want to test it on yourself?Archmage Hines rolled his eyes:
"Other than that, did you forget something?"
"what?"
"The vaccine must be handed over to the snake god! If it uses the blight technique to amplify your vaccine, one copy can be given to 100 people, wouldn't you have fewer vaccines to sell?"
"I'm counting on you too!"
Gretel spread his hands.
How to communicate with the snake god, how to train the native god, how to get the most benefit from it...
For such a difficult job, if a level 18 boss doesn't show up, do you expect me to be a level 10 rookie?
****
Ask for subscription, ask for monthly pass, ask for recommendation ticket, ask for book review, ask for various...
In the future, there will be more than ten consecutive days of 38-40 degrees, so painful...
(End of this chapter)
One group was screened for weakly virulent strains.
One group did research on vaccine production methods.
A group of people did research on vaccine storage methods.
One group is doing research on vaccination methods... The experimental group uses [epidemic technique] to urge the virus strain to be vaccinated, and the control group uses the injection method to urge the virus strain to be vaccinated.
The 20 plague mages, as well as the mages who were already in the research institute, were driven to death by Gretel.Just saving the vaccine exhausted the energy of that group of magicians:
"Dissolve the vaccine in distilled water!"
"Dissolve the vaccine with sterile saline!"
"Use 0.5%, 1%, 2%, ... 5% glycerin solution to dissolve the vaccine!"
“用5%蔗糖水溶液、5%蔗糖脱脂乳液、1. 5%明胶水溶液、1.5%玉米淀粉液……”
"Store at room temperature, store at 1 degrees above zero, store at zero temperature, store at -4 to 20 degrees below zero, store at -70 degrees, and freeze-dry at -[-] degrees!"
"Save for one day, 5 days, 15 days, 30 days... half a year, a year!"
"All combinations, all done again!"
The point is, it’s not just done.After the time is up, the preserved vaccine must be taken out to be thawed, diluted, and then injected into the mice again.Then observe the condition of the mice, whether they are sick, whether they have acquired immunity...
"Did you drill them too much?"
Seeing Gretel page by page, flipping through the reports handed in by each group, Archmage Hines couldn't help complaining:
"Even if you don't know exactly what to do, at least you have a general idea! Now that you're like this, are you letting them try combinations one by one until they die?"
"I just don't know how to do it!"
Gretel spread his hands confidently:
"I know how to do it. I just started. What do you want them to do? I just don't know, so I want them to try one by one! Don't worry, when they make other vaccines next time, they will have these plans anyway, and they can do it." Take it out and try again..."
"..."
"..."
No matter how Gretel squeezed his labor force, the research and development of the live attenuated yellow fever virus vaccine finally produced little by little results.Stable attenuated strain, successfully passed the test of 5 consecutive generations of transmission, the virus is genetically stable, and there is no sudden increase in virulence;
Research on vaccine production methods, using 7-day-old chicken embryos to inoculate the strain in the yolk sac, cultivating at 37.5°C~38°C after inoculation, and harvesting within 70~80 hours. With sufficient and stable egg supply and low price, it has defeated small vaccines. rat group and rabbit group;
(What? Cell group? Sorry, the cell group still failed to feed the cells and missed the competition)
For the vaccine preservation group, the optimum plan for harvesting the chicken embryos and storing them at -40°C, aspirating the liquid to confirm the sterility, grinding, centrifuging, and freeze-drying and sealing was determined;
As for the vaccination group...
"At present, it seems that the experimental group is inoculated quickly and efficiently, but the disadvantage is that the inoculation effect is unstable." Grete flipped through the experimental records in his hand—the experimental records of inoculating mice, and discussed with Archmage Hines and others. :
"It may be the reason [Plague Art] needs to be manipulated by a magician. Different magicians have different spellcasting strengths; even the same magician, affected by mood and manipulation level, the intensity of each spellcasting will be different."
This difference in intensity, so far, has not affected the protective efficacy of the vaccine—obviously, [Epidemiology] can be triggered, and there is still a lower limit for its strength—however, it has affected its safety:
"Among every 100 mice vaccinated with [Epidemiology], there is an average of 1 case of adverse reactions - including but not limited to redness and swelling at the injection site, pain, poor food intake, fatigue, moderate fever, nausea, vomiting, diarrhea, Convulsions etc."
"Please, this is the plague spell!" Archmage Haines sneered:
"What result do you want? It's just a little uncomfortable, which is already very mild compared to death."
"But the control group—that is, the group injected with syringes, is much safer." Grete turned the information in his hand to another page:
"So far, the adverse reaction rate is less than one in a thousand. In terms of the safety of the vaccine, injecting it with a syringe is a better method."
"But the syringe is too troublesome." Lynn said softly on Gretel's right.In this project, he followed Gretel from beginning to end, sucking, injecting, sucking, injecting, and dealing with syringes, he was almost vomiting:
"It's a very troublesome thing to sterilize so many needles every day... It doesn't matter in the research institute. I don't think everyone will sterilize the tens of millions of natives down the mountain..."
"This is the trouble." Gretel nodded slightly.In this world, no one knows better than him what will happen if the syringes and needles are not properly sterilized——
In the world before traveling, even with the widespread barefoot doctors, even with the productivity of the 80s and [-]s, vaccinations in mountain villages, there are still some places that are not strictly sterilized...
The result is widespread cross-infection.In a village, if one person gets hepatitis B or something, it will often lead to the recruitment of the whole village...
At that time, the level of productivity and personnel training were still the same. In this world full of natives, Grete did not dare to think about it.
"Using a syringe will cause widespread infection...a disease in one person will spread to everyone..."
"Then what do you want?" Archmage Hines frowned.Gretel turned his face and stared into his eyes expectantly, his face full of reason:
"I would like you to try it out, develop an inoculation device! Carve out the spell model, put the standard-strength magic crystal energy in it, and put the poisonous seeds in it—"
He made gestures and pressed down with his hand:
"Crack! The output is stable, the range is stable, and the adverse reaction rate is controlled in an extremely low range... Isn't this very good?"
"..."
That's good, but why did this kind of change matter come to me?
Archmage Hines wanted to complain very much.However, under Gretel's expectant eyes, he still mumbled in response:
"Okay, I'll do the job. It's also a necromantic spell, so digging a little deeper won't bother me... Shall I start now?"
"We have to wait a little longer." Gretel smiled:
"The vaccine needs to be tested on monkeys. If there is no problem with monkeys, it will be tested for safety on humans. After the safety is confirmed, the effectiveness will be determined, and then large-scale vaccination will be carried out. In the last stage, it is the test of epidemic disease that will contribute. opportunity……"
"Wait!" Archmage Hines looked at Gretel warily:
"Try it on people? You won't be the first to try it on yourself? ——I warn you, if you dare to do this, I will take you back to see your teacher..."
If it was in his previous life, Gretel, who followed in the footsteps of his predecessors, might have really injected himself with the first vaccine.But now, he just spread his hands:
"My physique is at least at the level of a knight. Hey... If you hit me, the reaction will be very small, and the safety test is inaccurate!"
According to what you said, if you weren't physically strong enough, would you really want to test it on yourself?Archmage Hines rolled his eyes:
"Other than that, did you forget something?"
"what?"
"The vaccine must be handed over to the snake god! If it uses the blight technique to amplify your vaccine, one copy can be given to 100 people, wouldn't you have fewer vaccines to sell?"
"I'm counting on you too!"
Gretel spread his hands.
How to communicate with the snake god, how to train the native god, how to get the most benefit from it...
For such a difficult job, if a level 18 boss doesn't show up, do you expect me to be a level 10 rookie?
****
Ask for subscription, ask for monthly pass, ask for recommendation ticket, ask for book review, ask for various...
In the future, there will be more than ten consecutive days of 38-40 degrees, so painful...
(End of this chapter)
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