Ninja World: Insect Princess from Konoha.

Chapter 308 Palace of Eternal Life
So how to turn this switch on.

Genes have an elaborate system for their expression.

Natural evolution shows her magic at this time.

Gene expression makes proteins, proteins make cells, and cells make life, which is the building block of life.

At the beginning of life, in a pond that was about to dry up, ultraviolet rays began to destroy the gradually exposed bacterial populations at the bottom of the pool. There was still a little time to wait for the high tide, and they had to survive this difficult period.

However, the genes of many bacteria have been broken by ultraviolet rays, and repair proteins in the body are urgently needed to repair gene damage.

But another inexorable act of bacteria disrupts this process.

That is reproduction.

When the related proteins start to repair the gene, the helicase and gene replicase will also come to the damaged site. They need to copy the gene to complete the task of reproduction, and several proteins will get stuck on each other.

The priority of reproduction is higher, and the repair will be forced in the middle.

At this point, a broken gene is replicated.

Cell genes that cause division are not expressed normally.

Then die.

Survival and reproduction are the basic needs of living things, and when the two choices are contradictory, death is caused.

Death means screening.

The life that cannot take the initiative to stop gene replication for repair is eliminated by death, and the gene that can actively stop copy for repair wins in survival.

Proteins that inhibit reproductively expressed gene segments require specific gene segments to be expressed.

But such a gene cannot be expressed all the time, and it will never be seen again.

Let her only express when the gene is broken, and be silent at other times.

How to do?
The protein that previously repaired the gene evolved to bind to the gene that inhibits reproduction and division when no damage occurs, and get stuck on it to prevent transcription.

When the gene is damaged, this protein will break away from the gene to repair the damage. At this time, the gene that inhibits replication will start to express, transcribe and produce the corresponding protein to hinder the expression of gene replication, and when the repair protein has finished its work, it will come back Suppression suppresses the expression of reproductive genes.

Healthy cells are able to reproduce again.

This is a complete life circuit, a simple and complex life program.

Bacteria used this circuit to solve the contradiction between survival and reproduction, and then gradually evolved more versions.

It precisely regulates all functions in the living body.

Among them, the most important repair function is not limited to genes, but also includes telomerase, which repairs telomeres.

Expressed in a variety of stem cells that have the task of dividing, it can repair telomeres just like repairing genes.

Therefore, the true length of life does not depend on telomeres.

The real problem is that this mechanism is not completely reliable.

Cells are so big that repair proteins can get lost in the intricate maze of cells, preventing the repair proteins that have done their job back to their previous jobs.

After more and more such events, it will cause the silenced gene to be expressed all the time, and the expressed gene will remain silent.

Mechanisms are out of order and cannot function properly.

This is where aging begins at the cellular level.

Since repair cells are so important, why not produce more repair cells so that the human body will not age.

Yes.

The gene that expresses the repair protein is called the life repair gene, and this gene exists in every life and every cell.

The difference is whether it is activated or not.

But genes will be ruthlessly silenced under the setting of selection.

The next thing to do is to trick the gene into keeping it active and working.

In theory, this would lift the lifespan limit.

The first thing to confirm is that a gene is a gene. Although anthropomorphic, genes have no emotions, no subjective consciousness, and genes themselves can make mistakes.

At this time, what is stuck is the underlying genetic logic bug.

Maggie has five options.

First, after discovering this kind of thing, the first thing to do is to find out this gene, by destroying the inhibitory protein, unsilencing it, and producing a large amount of repairing protein.

Gene repair will try to re-inhibit this expression, regardless of its expression, it will be continuously released within a certain period of time. As a result, a large number of repair proteins will be obtained, and the goal will be achieved.

That's what Meggie is doing now.

This gene was discovered by Meggie in bugs. Before that, Meggie had done many experiments on immortality, but in the human body, she can only find similar gene segments. Although the scope has been narrowed down, comparisons are needed.

Time is tight, it's a race.

The second is gene editing, which uses the working mode of genes.

Before life reaches the peak of growth and development, genes will produce a large amount of repair proteins for their own use. After reaching middle age, genes will turn off expression and reduce the production of repair proteins.

Here comes the question, how do genes determine age.

There is a specific blank segment on the gene, which is not involved in the expression of any protein.

Instead, as cells age, they gradually carry methyl groups, and the older they are, the more methyl groups they carry.

Cells will judge their own age based on this, change epigenetic expression, and die when they deserve to die.

So will demethylation affect the judgment of cells?

meeting.

But there is a small problem. There are [-] trillion cells in the ninja body.

Even in an ordinary human body, there are forty to sixty trillion cells.

This huge workload, demethylation one by one, is a big project.

It doesn't make sense for a single cell to become young.

Even if the methyl group is demethylated, it will re-carry the methyl group over time.

Thirdly, as a mutual exclusion lock in the life circuit, the life repair gene should have a corresponding gene segment that can inhibit its expression, and this gene segment is in an open state.

Deleting this gene segment will destroy the expression of its switch. In theory, the production of repair proteins will be in a state of constant excitation.

Solve the problem of aging once and for all.

As long as the energy in the living body can keep up, immortality can be achieved.

The problem is, Mei Ji did not find this gene segment.

Furthermore, will this violent method really not cause a chain reaction and cause adverse side effects?

It's not a matter of missing a screw.

Fourth, this is the way Maggie can do it now, the influence of signals.

To name a few examples, calorie restriction, that is, caloric restriction.

A seven-percent full nutritional intake is enough to maintain life activities, but in the prehistoric harsh living environment, it is right to eat more. This gives the body a signal that the current environment has sufficient food and can mate and reproduce. Now that the task is completed , then you can die.

On the contrary, if the calorie intake is restricted, the body will think that the current environment is short of food, the survival rate of offspring is low, and it is not suitable for reproduction, so the expression of repair proteins will be increased, and the genes will be adjusted from reproduction mode to survival mode, prolonging life in disguise.

This situation is expressed in Xia Chizu. Meiji will provide limited food intake to Xia Chizu who is prohibited from moving.

In the same way, appropriate cold stimulation and appropriate exercise will give the body this signal.

This effect is applicable to almost all carbon-based organisms, and it is the same for human beings. Because of human nature, it is difficult to strictly discipline oneself, and this method does not apply.

Then it is feasible to directly input signals to the body and stimulate the body to produce relevant responses.

But there is a limit to this. Immortality requires an infinite ability to repair.

Moreover, the current situation is not applicable. The key to this method is the right amount. If it is too much, it is courting death. Especially now, the genes in the patient's body have quietly activated the self-destruct program.

Meggie didn't see the reason behind it clearly.

There is a small molecule whose function is to deliver substances to various reactions in the cell, so that it can provide support for various reactions.

Used in metabolism, building cells, sending signals within cells, and is essential for mitochondria to convert food into energy.

What's more, it's a great fuel for repair protein activity.

This thing can improve the efficiency of protein repair.

In the process of working, the repair protein must have the chemical reaction of this molecule and the various support functions provided.

This is vital to life, without this substance life would die within seconds.

Almost all cells in the body need its help to complete their functions.

Just like an engine starts, oil is needed as fuel. Although this analogy is not exact, it is similar.

The signal mentioned earlier stimulates the body, which actually stimulates its production to increase and enhances the ability of cell metabolism and repair.

Of course, there are other important elements in the human body, without which we cannot live.

These elements can be produced by Tsunade through Yang Dun, that is, vitality.

But this thing is different, the body of other elements can increase the production through intake of energy, the production of this fuel is not limited by materials, but also controlled by signals.

When cell necrosis releases information factors to attract immune cells to engulf itself, this signal will also be received by every production factory, and this signal is a signal to reduce production.

The logic is that when there are more necrotic cells, the body needs to consume more energy to repair, which may occupy more survival resources for future generations. At this time, the self-destruct system achieved by gradually reducing production in the body is quietly activated.

This self-destruction is influenced by factors marked by the age of the cell.

With the increase of age, cell necrosis, gene production is down-regulated, which leads to the restriction of various functions related to it, more damage will occur, and the consumption of cell repair will increase, which requires further production limitation. Leading to more impaired cell function, more cell necrosis, and a vicious cycle.

Without it, the human body will die within seconds.

Madara's cause of death is based on this.

Maggie called it the smell of death.

Then, Tsunade can add it, so can it be poured into the human body?

No, the body locked it up.

The cell membrane refuses external fuel to enter the cell to function, and can only produce it by itself.

This is the monopoly that prevents outside interference with the aging process.

And the fifth option is a bit outrageous.

Maybe Maggie can try to equip the lost repair proteins with a wicked navigation, telling them where they should go back and where they should go to work.

This is also achievable.

Something similar is the gene-targeted drug, the special drug that Meggie is going to make now.

In nature, a typical thing with this function is a virus.

Undoubtedly, the virus is under the control of Maggie, although this domination is useless, Maggie can only turn on and off the function of the virus, because the virus has no other functions, but what Maggie needs is the template of the virus.

Cells have monopolized the production of fuel, so how to transport fuel in, smuggling.

Targeted release with virus.

The parasite can do the same operation, but without the precise control of Maggie, it cannot realize this complex function by itself. It needs a lot of targeted training, deep learning, and the formation of behavioral algorithms.

Therefore, the treatment of one person is okay, but Meiji cannot be saved if there are too many.

The virus is much more affordable, a large amount of delivery, a large amount of control, under the absolute amount, the infection will always be successful and the goal will be achieved.

The worm avatar was carrying out related experiments, nervously making medicines, and couldn't help muttering while busy.

"Sure enough, Orochimaru's way of immortality is the easiest and most affordable way to change to a young body."

For Maggie, the only way to live forever is.

Improper person.

For the permanence of the individual and the continuation of the group, Maggie chooses the latter which is more efficient.

Because the former are extinct in natural selection.

(End of this chapter)