Xueba is also open

Chapter 421 Teacher, I want to study him!

He Lan's jumping incident not only did not add negative influence to Puze, but brought him a good reputation bonus.

As for the development of the follow-up matter, Bai Ye didn't pay any more attention, because Chang Lili had asked for leave, annual leave in advance, plus sick leave, she might have to rest for a while.

It may be that He Lan's incident had a greater or lesser impact on her. He Lan went to submit an application, and the leader quickly approved it.

The director of the [-]th floor department is called Zhao Xiaojun. He used to be the deputy director under Jiao Liming, but after the mental health department was established, Zhao Xiaojun became the director. Therefore, Zhao Xiaojun has always respected Jiao Liming.

After Chang Lili rested, Zhao Xiaojun approached Bai Ye and asked him if he would like to stay in Keli for a while, but Bai Ye did not refuse and agreed decisively.

Because during this period of time when I was on the fifteenth floor, I felt a lot about Bai Ye, and even had a lot of feelings about Bai Ye's future medical career.

If the body is sick, it can be adjusted by regulating the body, but if the mind is sick, how to treat it?

Bai Ye began to ponder over this question.

Among the illnesses on the fifteenth floor, the most common and most common are depression and anxiety. In fact, these two are completely different diseases. Whether it is manifestation or treatment, they all start from two diametrically opposite directions.

Depression is a common mental illness characterized by long-term low mood. The symptoms are often inconsistent with the environment. The clinical manifestations are mostly gloomy, severe grief and even stupor. .

Moreover, the terrible thing about this disease is that once depression occurs, it is easy to relapse, but each attack can be relieved in most cases, and in some cases it will leave sequelae or turn into a chronic course.

Depression can have many causes, but is often accompanied by loss of interest, low mood, self-blame, guilt, low self-confidence, decreased energy, poor sleep, and decreased appetite.

At least 10% of patients with depression will have manic episodes, which is the so-called bipolar disorder. Some patients have significant anxiety and motor agitation, and severe patients will have hallucinations and other psychotic symptoms.

According to statistics, two-thirds of depressed patients have suicidal thoughts, the suicide rate of patients with severe depression is as high as 2% to 3%, and 10% to 15% of suicide deaths are related to depression.

So, with such a high fatality rate, is there any other disease that can match it?
Anxiety disorder is also a common mental disease whose main symptoms are unpleasant and painful and often accompanied by physical discomfort. 3.66% to 28.8% of people suffer from this disease for life, and more than 90% of the patients are before the age of 35. Onset, women with anxiety disorders tend to be more than men.

Although depression and anxiety are two different mental illnesses, they often appear clinically at the same time, and many clinical symptoms are the same, including poor sleep, decreased appetite, decreased energy, and irritability.

When depression and anxiety disorder exist at the same time, it is called comorbidity of depression and anxiety disorder in clinical diagnosis, and it is one of the most common forms of comorbidity in psychiatry.Studies have shown that 60% to 90% of depressed patients also have anxiety symptoms, and more than 50% of depressed patients also have anxiety disorders that meet the diagnostic criteria.

Why anxiety is called anxiety disorder, because most anxiety patients will have a feeling of physical disorder, which will make people feel uncomfortable. Some people feel flustered, but there is no problem with the electrocardiogram, and the color ultrasound of the heart shows that this is normal heart function.Some people feel short of breath and wheezing, but their lungs are very good, and their airways are very normal, etc...

Anxiety disorders seem to be accompanied by all kinds of discomfort, and this disease is like a problem with the brain, which will control the discomfort in various parts of the body.

Moreover, there is no reason or solution for this discomfort!
Bai Ye didn't believe this, he felt that there must be something that controls the human body's spiritual emotions, there is some kind of dynamic balance substance in the human body, and this substance can control human emotions Wait for all kinds of emotions.

It's just that this kind of thing has not yet been discovered!

If the body is sick, it can be treated, but if the heart is sick, how to treat it?
This seems to be a terminal illness, afflicting all kinds of people.

If your friend suffers from a certain disease, such as pneumonia or broken bones, you may speak generously when someone asks you, but if it is a mental illness, you may not even be ashamed to say it.

Bai Ye now has a sense of mission. He feels that he should work hard for it, to study the mechanism of these diseases, and then solve this problem.

Because these diseases are too harmful!
He is not only hurting himself, he is constantly affecting others, even the society.

Studies have found that: the impact of depression and anxiety on others and society The occurrence of depression and anxiety disorders will have a significant impact on the individual's physical and mental health, work level, social ability and physical activity.Because patients have a low evaluation of their own physical health, and some patients have a decline in various social functions and physical activity, they will cause damage to many social functions, resulting in problems such as inability to work normally, disharmony in marital relations, and parent-child relationships. question.

The impact of depression and anxiety on life and health One of the common symptoms of depression and anxiety patients is suicidal behavior, which will cause great harm to themselves and their families, even if suicide attempts will cause harm to their own bodies, and there is a possibility of repeated suicide .Suicide due to depression and anxiety has become a major cause of population death.

and!

This disease is hereditary!
That’s right, he will inherit it. Studies have found that the occurrence of depression and anxiety is closely related to genetics. The probability of the same disease among relatives is much higher than that of the general population, which is 8 to 20 times that of the general population, and the closer the blood relationship is, the more likely the disease will be. The higher the consistency, such as parents, brothers, and children's immediate relatives, the incidence consistency can reach 12% to 24%, dizygotic twins can reach 12% to 38%, monozygotic twins can reach 69% to 95%, and cousins ​​can reach 2.5% to [-]%. [-]%.

Other data show that the role of genetic factors increases with age.The current research has not fully revealed the specific inheritance mode of depression. The expression of abnormal genes or the failure of normal genes to express are the mechanisms that cause most mental diseases.The combination of heredity, environment, and psychological factors often affects the occurrence of depression, and it is determined that depression and anxiety are mostly polygenic genetic diseases.

Bai Ye feels that since this is a genetic disease, there must be a substance that is constantly changing the human gene, so that a genetic structure can be changed and a genetic disease can be formed. result.

So, after wanting to understand this point, Bai Ye started to prepare.

Every day, Bai Ye got up early and worked late at night. He consulted various documents to study what caused this change.

During this period, Zhao Xiaojun also began to accept patients one after another. It has to be said that after he really understood the patients, he went to the books after going through the clinic. He got more things and improved faster at the same time.

During this period of time, Bai Ye pushed all the things around him away, and spent the whole day researching the causes and treatment options of anxiety disorders and depression.

Time at this time is always merciless and fleeting in the blink of an eye, but after Bai Ye went through clinical tests, he found several things that were currently monitored and related to anxiety and depression.

From the perspective of biochemical analysis, the possible factors mainly include 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT), norepinephrine (norepinephrine, NE), dopamine, acetylcholine and aminobutyric acid.

These five indicators are directly related to anxiety and depression in the human body. At present, various drugs are also treated based on these five biochemical components.

However, these examinations are extremely expensive. This is not a simple test and blood drawing. It is extremely expensive to monitor these human substances.

But if you really want to have a thorough treatment and achieve a good curative effect, you have to study the real level of these five indicators in each person's body.

If you want to study this thing thoroughly, the next thing to do is to start with these five indicators, investigate each hospitalized patient, and then score the patient's symptoms, conduct meta-statistical analysis, and analyze the research results.

As long as these things are thoroughly studied, the treatment should be symptomatic treatment.

After thinking it over, Bai Ye felt that he should treat this matter as his graduate project.

But before that, Bai Ye used the computer to look up all the cases since the construction of the department on the [-]th floor in the past ten years. These cases are all the cases of treating patients after the establishment of the psychiatric department.
Every inpatient has an inpatient case, and these cases are valuable research materials.

Puze Hospital has popularized computer medical records for less than ten years, but the psychiatric department on the fifteenth floor has been established for a long time. Many patients' medical records are handwritten versions. To find out, it is necessary to study historical cases.

So Bai Ye found the medical record room, where the hospital's medical records have been sealed for 20 years.

Every patient has a medical record. After being discharged from the hospital, the paper version of the medical record will be sent to the medical record room, and the hospital will keep it for 20 years. Within these 20 years, the patient can use their identity information to copy and investigate the medical record.

At the same time, doctors can also investigate cases for research.

However, the latter is relatively rare. Many cases of patients after discharge are shelved by doctors and will not be studied at all.

Because many doctors have become slaves to work and lost the instinct to think.

But Bai Ye is not like this. He knows the importance of these things. These are countless research experiments and data, which are very detailed. Every case is a very comprehensive research data.

It took Bai Ye half a month to go to the medical record room every day when he was free, and he went to collect all the data he needed.

Finally, after sorting out the data, he conducted various statistical analysis.

During this period of time, Bai Ye can be said to have devoted himself to it.

In the end, Bai Ye had a result about the treatment methods for anxiety and depression on the fifteenth floor of Puze Hospital.

Medication is still the mainstay of treatment for depression.

He found that no matter how fast the development of antidepressants is, how the varieties and types increase, they can only be divided into two types of heterocyclic antidepressants, tricyclic and tetracyclic, according to their chemical structures.

Tricyclics are classic antidepressants, which are currently classified according to their mechanism of action, mainly including selective 5-HT and NE reuptake inhibitors (such as venlafaxine); selective 5-HT reuptake inhibitors (such as fluoxetine); selective NE reuptake inhibitors (e.g. reboxetine); selective 5-HT reuptake activators (e.g. tianeptine); NE and specific 5-HTergic antidepressants (e.g. azapine); 5-HT balance antidepressants (such as trazodone); NE and dopamine reuptake inhibitors (such as bupropion); reversible monoamine oxidase inhibitors (such as moclobemide), etc.

In addition, traditional Chinese medicines are gradually accepted by patients due to their mild effects and few adverse reactions. Antidepressant effect.Therefore, research on the antidepressant effect of traditional Chinese medicine and its prescriptions has great potential for excavation, and has great social significance for treating the increasing number of patients with depression.

However, these drugs can only temporarily relieve and suppress the development of the disease, and cannot cure it!
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It's already September, and it's time to prepare for graduation projects.

Although he didn't make it clear to prepare the opening report, he also told everyone that they should start preparing for this matter.

When Bai Ye found his mentor, Liu Boli was sitting in his office reading a book.

At his age and stage, there is no need to spend every day in the hospital, but this stubborn old man comes to his place of work on time every day, whether it is an outpatient clinic or in the office, he is very punctual.

Seeing Bai Ye coming in, Liu Boli closed the book. Bai Ye rarely came to him on his own initiative, but every time he came, he must have something serious to do.

"Hello, teacher." Bai Ye bowed.

Liu Boli nodded: "Sit down, what's the matter? What do you want from me?"

He asked straight to the point. In fact, he was very satisfied with himself as a student, and he always brought him surprises from time to time. However, wherever he went, it can be said that he had changed a lot!

The anorectal department has become a regional diagnosis and treatment center from a general department, a national key specialty, and a national anorectal demonstration site.

Just a few days after I went to the [-]th floor last month, the two chief directors of the Department of Acupuncture and Moxibustion and the Department of Encephalopathy were alarmed. The facial paralysis recovery acupuncture was very effective, and the Facial Paralysis Recovery Center was established directly.

And Wang Wenliang was also very clever. Taking advantage of this opportunity, he directly applied for the project. It is estimated that the National Natural Science Foundation of China must have nothing to do this time.

If the research is thorough, and the facial paralysis rehabilitation clinic develops into a facial paralysis rehabilitation center, all of this will come naturally, and it will not be a problem at all.

The Department of Encephalopathy is no different than other departments. He was originally a key specialty. Now he has reached a bottleneck in his development, and every step is very difficult. However, these bottlenecks do not seem to exist in Bai Ye's place. A small operation can be easily broken. .

This kid is really a gift from God to Puze!
No, it should be a gift to Chinese medicine.

Liu Boli suddenly remembered that when Zhao Xiaojun met him, he said that Bai Ye had gone to the fifteenth floor, and had been studying there for a while.

According to my own understanding of this kid...

Is it...

Thinking of this, Liu Boli immediately regained his spirits. Did Bai Ye have any special views or thoughts on the mental health department?
After this idea was born, he could no longer restrain his well-controlled heart rate...

Liu Boli took a deep breath. He felt that when talking with Bai Ye, he should adjust his exhalation and heartbeat, so that he could stay calm everywhere.

Seeing Mr. Liu looking at him calmly, Bai Ye couldn't help but feel uneasy.

"Teacher, it's like this. I found in the psychiatry department that the current treatment methods for depression and anxiety disorders are somewhat inappropriate."

"I found through a large number of various materials that, from a biochemical perspective, the possible factors affecting the development of the disease mainly include 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT), norepinephrine (norepinephrine, NE) , dopamine, acetylcholine, and aminobutyric acid."

"Although many studies in recent years have supported the 5-HT hypothesis, studies have shown that 5-HT is directly or indirectly involved in regulating people's mood, 5-HT levels are reduced and depression is related, while 5-HT levels are increased and mania is related; However, many studies have reported that the occurrence of depression is related to the content and regulation of NE, dopamine, acetylcholine, and aminobutyric acid, and more research work is needed to truly reveal the biochemical mechanisms of depression and anxiety."

"Then I collected and counted the main means and analysis of our hospital's treatment of the disease over the years, and came to a conclusion..."

After Bai Ye finished talking about the latest things he had done, he turned to Liu Boli:
"Teacher, I want to study this thing!"

(End of this chapter)