This doctor has a system

Chapter 353 424. Damn woman, hurt my vitality

Gao Feng opened the brochure and took a closer look. The patient turned out to be a boy over 1 year old, 1 year and 10 months to be precise.

According to family members, the child learned to walk when he was more than 1 year and 1 month old. The family was very happy at that time. The child was also very curious about walking and would take a few crooked steps if nothing happened.

Soon, when he was 1 year and 5 months old, his walking became more and more stable and he no longer liked being supported by adults. Watching him grow up day by day, the whole family feels very happy.

But something unexpected happened. One day, the child's mother discovered that her child had been walking unsteadily and kept falling down. At first, she didn't care. She just took care of her more carefully to prevent the child from falling and bumping.

But she soon discovered something was wrong. The child was walking more and more unsteadily these days, and seemed to be slowly losing the ability to walk.

This frightened her, and she hurriedly informed other family members of the situation. This suddenly stirred up a hornet's nest, and a bunch of people came to the hospital with their children.

I went to the neurology department for a checkup, including MRI and electromyography, but no problem was found. The child's condition has been getting worse and he can no longer walk.

Before this multidisciplinary consultation, the doctor in charge had actually called in many experts, including several big names from Beijing Children's Hospital. Everyone had their own doubts, and there was no conclusion yet.

"We all know the patient's condition pretty much, and we can express our opinions in a while." Director Wang from the Medical Education Department said slowly, "But you must be careful with your words. The patient's family members will also come over soon, so don't irritate them."

Speaking of this, Director Wang is also a little helpless. It is difficult to take care of rich patients, and it is even harder for powerful patients, especially when the patient is still a little baby. If something goes wrong, the parents may not be able to accept it.

Not to mention him, Dean Guo now has a headache.

Everyone had a buzzing discussion for a while, and soon the patient's father arrived. He was a man in his 30s with a haggard look on his face.

"This seems to be Zhou X's son." Gao Feng heard someone whisper next to him.

Is it such a big deal? Gao Feng was also a little surprised. What surprised him was that the patient's identity was so unusual. Why didn't he go directly to the capital?

In fact, this was because he didn't know much about the situation. The child had actually been treated in a hospital in Beijing, but the cause of the disease was not found. The family members felt there was no hope, so they returned to the province.

"I think it is still a neurological disease." A director commented, "The patient's ability to walk is gradually lost."

"Yes, I agree with Director Liu's opinion." Lu Yifei from the Department of Neurosurgery echoed, "Electromyography examinations still need to be reviewed, as some diseases may not show up early."

Most of the people who expressed their opinions were directors who were both internal and external. After all, the patient's symptoms were here, and other departments were just here to make matters worse.

"Could it be congenital muscular dystrophy?" Someone said, "The patient has decreased muscle tone and contracture of the proximal joints. I think a muscle biopsy is needed."

"A muscle biopsy was done and no problems were found," the doctor in charge said.

"Could it be Duchenne muscular dystrophy? Has genetic testing been done?"

"We did genetic testing in Beijing, and so far we have only ruled out X-linked childhood spinal muscular atrophy," the doctor in charge reported.

No one will comment anymore. This is obviously a difficult and complicated disease, and the diagnosis is definitely not something that can happen overnight.

Some diseases are like this. In the early stages, the symptoms are atypical and diagnosis is difficult. Only when all symptoms appear in the later stage can the real culprit be found.

However, the disease may become more serious at this time, and many patients cannot wait until this time.

It's like some patients died inexplicably, but many family members refused to do autopsies. The reason was very simple. There was no one alive, so what's the use of looking for reasons.

This patient is so young, and given his special status, it is impossible to wait and let the disease develop.

"Care for the flowers of the motherland: This is a child with great luck. He was born in Rome. But now this lucky person is in big trouble and needs your help. Complete the task of caring for the flowers of the motherland to get 100 skill points. No skill points will be deducted for failure." The system issued the task.

100 skill points? Gao Feng was shocked and outrageous. He had just seen the patient and felt that he was just an ordinary child with the same appearance.

But he was shocked. He was still very concerned about this child. After all, he was such a young child, so it would be best if he could help figure out the diagnosis.

He also tends to have a problem with the neuromuscular system, and further examination is definitely needed.

The only thing that made him feel a little uncomfortable was that the patient was too young and could only speak three-character words and could not express what he meant.

"Could it be spinal muscular atrophy?" Gao Feng said, "I just discovered that the child also has muscle weakness in his upper limbs."

At that time, the child's mother brought a lollipop to the child. When the child took it, it was very difficult. Gao Feng pulled the lollipop out of his hand without even using any effort.

The child started crying at that time, and the little guy thought someone was trying to steal his candy.

"There seems to be a professor in Beijing who has also talked about this disease." The patient's father also said at this time, "But other people said that the symptoms are not very consistent."

So I didn’t lean in this direction again at that time.

"You can do a genetic test. Our company's laboratory can do multiplex ligation probe amplification and real-time fluorescence quantitative PCR." Gao Feng said, "The results will be available in 2 days."

The patient's father didn't think anything of it, but others felt complicated when they heard this. What do you mean by my company? ? ? Is this what workers should say?

"Then let's take a look." Director Wang from the Medical Education Department said when everyone was silent.

Maybe because of repeated visits to the hospital these days, the child has lost a lot of weight than before, and the blood can't be drawn out, so the nurse has put a lot of effort into it.

The specimen was sent directly to the laboratory of Z University. Lu Yingtao and two people quickly processed it. Genetic testing sounds very high-end, but the principle is also very simple.

It is a technology that detects DNA through blood, other body fluids, or cells. It takes the peripheral venous blood or other tissue cells of the subject, amplifies the genetic information, and then uses specific equipment to analyze the DNA molecular information in the cells of the subject. Detect and analyze the gene type and gene defects it contains and whether its expression function is normal.

The results came out the next day, and the report showed a homozygous deletion of exon 1 of the SMN7 gene.

"Is it really spinal muscular atrophy?!" A professor from Beijing Children's Hospital was stunned for a moment after looking at the report, "This symptom is not very typical."

He was the one who considered X-linked spinal muscular atrophy in young children. Now it seems that his consideration at that time was not very comprehensive, but fortunately, at least the child now has a clear cause of the disease and a direction for treatment.

The family members of the children are undoubtedly the happiest people, and everyone is full of confidence in future treatment.

Their idea is very simple. Once the cause of the disease is found, wouldn’t it be enough to treat the cause? The family is not short of money, so any problem that can be solved with money is not a problem.

However, seeing the solemn expression of the doctor in charge, the patient's father had an ominous premonition.

"Doctor Xu, let's go out and talk."

"You mean that although the diagnosis is clear, there is still no way to start treatment?!" He looked unhappy, "Can you explain to me the reason?" Dr. Xu, who was in charge of the child, was also a little embarrassed, but he communicated with the patient's family The condition is his responsibility.

"There are currently no specific drugs for spinal muscular atrophy, and the main focus is rehabilitation training and symptomatic treatment." He explained, "In the later stages, patients may be unable to sit alone and have insufficient breathing and ventilation, and may need to wear a ventilator."

"How many hours a day should I wear this ventilator?" the patient's father asked with a frown, "or should I wear it at night while sleeping?"

"Keep wearing it," Dr. Xu hesitated for a long time before saying.

"Then will he be able to walk independently in the future?" The child's father's voice was trembling.

"It's hard to say, but judging from the current development of the condition, it is estimated that he will not be able to live an independent life."

After listening to what he said, the patient's father was silent for a long time. He really didn't expect that the result would still be like this after the diagnosis was confirmed. What will happen in the future? The wife will definitely not be able to accept it, so what should the child’s grandparents say?

What should the child do if he cannot live a normal life when he grows up?

In fact, what was even more cruel was that Dr. Xu did not tell him that patients with rapidly progressing spinal muscular atrophy usually do not grow up to adulthood, and repeated lung infections can kill the child.

Gao Feng thought he would receive 100 skill points, but after waiting for a long time, there was no system prompt.

"System, what's going on? Where are my skill points?"

"You have not completed the task yet and cannot settle the task at the moment." The system replied.

Haven't completed the task yet? Gao Feng was stunned for a moment, but the patient's diagnosis was already clear! Are there any other problems with the merger?

"That's not true, but your mission is to protect the flowers of the motherland. The child's current diagnosis is clear, but the condition has not improved." The system explained, "So you are currently unable to obtain skill points."

Gao Feng was silent at this time. The key is that the flower of the motherland is suffering from spinal muscular atrophy. There are currently no effective treatment drugs. The subsequent treatment may not be satisfactory.

"You can develop a drug for him." The system suggested, "You are fully capable of this."

Damn, you’re trying to trick me into skill points again! Gao Feng thought.

There are currently many ways to obtain his skill points, but he is actually not rich. Many times he spends them inexplicably. His current balance is only over 600 points. He originally wanted to wait for a while before opening a new project.

It is not impossible to develop drugs for a patient, but this person must have a special meaning to him, otherwise other patients will be waiting for love and care. Gao Feng still prefers to develop drugs or medical devices with a relatively large audience. Just like ECMO.

脊髓性肌萎缩症作为一种罕见的常染色体隐性遗传神经肌肉疾病，发病率约为1/10000～1/6000，携带率为1/50～1/40，中国发病率为1/9788万活产婴儿，携带率为1/56。

But after returning home and seeing his son, Gao Feng suddenly changed his mind.

"Jiaran, what are you doing?"

"Nothing to do, I'm free right now." Hu Jiaran said on the phone.

"Okay, come and see me later."

Hu Jiaran started to get dressed.

"No, you want to leave?" Zhang Yumeng said in disbelief, "It's over, I met a man who wouldn't recognize anyone when he put on his pants."

If you don’t leave, I will run, Hu Jiaran thought to himself.

"I'll take you home so you can have a good rest." He smiled. "It should be important for the boss to come to me for something."

And he has done everything he needs to do, so it is pointless for Niwai to take such a long time. He is in the sage time now and does not want to be influenced by the love of his children. He understands everything.

When walking, Hu Jiaran felt a little weak in his legs. It seemed that he couldn't work so hard in the future. He secretly thought to himself, hateful women, hurt my vitality.

"Do you know about spinal muscular atrophy?" Gao Feng asked.

"I don't know." Hu Jiaran and Li Youliang replied.

"I am going to develop a specific drug for this disease." Gao Feng said, "The sooner the better."

"I agree." Li Youliang said immediately.

Hu Jiaran glanced at him speechlessly. Of course you agreed. Anyway, if you just talk, this matter will definitely fall on me.

However, he did not feel too embarrassed, because now his subordinates are not what they used to be, and it is no exaggeration to say that they are full of talents.

"How about I go back first and let everyone check this information?" Hu Jiaran asked.

"Okay, you can go back and discuss it first to see if you have any clues." Gao Feng said, "I will go to the laboratory to communicate with everyone in three days."

Gao Feng has already seen this information in the system space. The system is as powerful as ever. It mentions a detailed drug manufacturing technology called Nosinaxin Sodium, but the price of skill points is as high as 350 points.

It was also mentioned in the previous article that patients with spinal muscular atrophy have a homozygous deletion of exon 1 of the SMN7 gene, and nosinaxin sodium, as an antisense oligonucleotide, can increase the expression of SMN messenger ribonucleic acid (mRNA) transcripts. Incorporation of exon 7 and production of full-length SMN protein.

Through this mechanism, the survival and important functions such as movement and breathing of SMA patients can be significantly improved, and the disease process of SMA can be changed.

"Substrate synthesis failed." The system prompted.

"Substrate synthesis failed ×10" the system prompts.

"Substrate synthesis failed ×100" the system prompted again.

Gao Feng was so tortured in the space that he felt like dying. "Stop pushing," he said to the system.

Yoshihisa

"System, are you mute? Why don't you say something? How about my steps?"

system

Three days later, Z University Pharmaceutical Laboratory

"Do you have any ideas?" Gao Feng asked.

No one said anything. Although most of them had participated in drug research and development, they all acted as screws and could not help at all with the design concepts before drug development.

(End of this chapter)