Daming: I, Yang Xian, really govern Yang!

When Shangguan Yu'er was stunned, Yang Xian reached out and took the other person's left hand, then pulled up his sleeve, revealing the white arm underneath.

"It's going to hurt a little bit later, just bear with it."

As Yang Xian spoke, he quickly made a cut on Yu'er's left arm with the scalpel in his hand, and then immediately planted the liquid vaccinia vaccine.

"Are you ready?" Yu'er asked.

"Okay." Yang Xian put the tools back into the medicine box and said.

"Didn't you say it would hurt a little? Why don't I feel it at all?"

Yu'er frowned and glanced down at her arm. If the wound on her arm hadn't proved that she had been vaccinated with cowpox, she would have thought nothing had happened.

Yang Xian glanced at Yu'er and felt that the conversation between them just now was strange.

Also, I don’t know whether I should say it’s because my skills are too good, or because Yu’er’s reflexes are too crazy. No matter what, her arm was cut open and she bled.

While Yang Xian was inoculating Shangguan Yu'er with cowpox, there was one person who watched intently throughout the whole process, and that person was Wu Sihai, the president of Taiyuan Hospital.

Wu Sihai asked curiously: "Is the method used by Yang Guogong the same principle as Ge Hong's medical book "Elbow Preparation for Emergency Prescriptions", which uses the method of fighting poison with poison."

Yang Xian looked back at Wu Sihai and said with a smile: "As expected of Dr. Wu, he has profound medical knowledge."

Even though Wu Sihai was helpless in facing the diseases of Xu Da and Zhu Xiongying, just deny him because these two diseases cannot be cured in this era, and it is not because Wu Sihai's medical skills are incompetent.

Being able to reach the position of head of the Taiyuan Hospital is enough to prove Wu Sihai's talent.

Many people have always thought that immunity and vaccines are concepts of Western medicine, but they are not.

The word immunity was first seen in a medical book "Immunity Prescriptions" in the Ming Dynasty of my country. This book talks about "freedom from epidemic diseases", which means the prevention and treatment of infectious diseases.

The use of modern "immunology" concepts to prevent diseases goes back even further. Ge Hong of the Jin Dynasty recorded in "Shi Fangfang" that after being bitten by a mad dog, to prevent and treat rabies, the bile of the mad dog can be used , applied externally to the wound.

In the middle of the Ming Dynasty, in order to prevent and treat smallpox, the people invented the variola vaccination method, which was hundreds of years ahead of the West.

The methods used mainly include the following.

Take the underwear of children with smallpox and wear it for two or three days on healthy children without acne to achieve the purpose of vaccination, which is often called the acne clothing method.

The second method is to take fresh acne slurry from children with smallpox, dip it with a cotton swab and insert it into the nostrils of the vaccinated subjects, thereby triggering acne and achieving the purpose of vaccination.

In addition to these two methods, there are also dry seedling method and water seedling method. These two methods require a certain degree of processing of variolation and appear to be much more professional and mature.

But no matter which vaccination method is used, one thing will not change, that is, the vaccination will be variola.

The idea of ​​variolation is very simple, fight virus with poison, but the actual operation is extremely risky. How to reduce the toxicity of the virus without losing its ability to stimulate the body to form immunity was a huge challenge even in Pasteur's time. The smallpox virus is different from other viruses. Once the virulence is not weakened, it is equivalent to artificially contracting smallpox, with a risk of up to one-third of death.

Sometimes the virus does not weaken much. It is not fundamentally different from getting smallpox directly. It is completely a matter of character.

You thought it was causing low-intensity smallpox, but in the end it turned out to be a life-threatening talisman.

However, the probability of death is much smaller than the probability of death after being infected with smallpox. Therefore, variolation is still a great invention in history, and the method of vaccinating cowpox later invented by Jenner was derived from variolation in my country.

By the Qing Dynasty.

When they first entered the customs, the Manchus faced a huge risk of smallpox infection, and many Manchus, including members of the royal family, died as a result.

1649 was the fifth year after the Qing Dynasty took control of Beijing.

Just after the Spring Festival, there was panic in Beijing. It wasn't that another enemy army was coming, but that smallpox broke out. The news spread quickly among the people, and the people in the capital were in chaos, similar to the capital of the Ming Dynasty this time.

But the Qing Dynasty's method of handling it was completely different.

On the 30th day of the first lunar month, Prince Regent Dorgon ordered that residents with registered residence in the capital who had never had acne, as well as strangers without permanent residence in the capital (regardless of whether they had acne or not), should "agree to be taken out of the country twenty miles away" in accordance with the imperial court's acne prevention system. ".

For ordinary people, this is nothing less than a disaster. Later generations saw this narrative in a 1645 memorial by Zhao Kaixin, the censor of Nancheng, who was inspecting the capital. Without food, young and frail children are often left on the roadside to starve to death.”

The common people were driven away, and the royal ministers fled everywhere.

Following Huang Taiji's example, Emperor Shunzhi also built a pox shelter for himself in Nanyuan and Xiyuan.

Whenever there was a slight disturbance, Emperor Shunzhi would rush to avoid acne and go to Nanyuan outside the city early to avoid acne. The nobles of the Qing Dynasty who stayed in the city also closed their homes one by one, waiting anxiously for the plague to pass as soon as possible.

There are as many as five such situations recorded in official history alone.

Despite heavy defenses, the smallpox virus was hard to prevent.

Emperor Shunzhi did not become a monk due to infatuation as written in The Deer and Cauldron, but died of smallpox.

Emperor Shunzhi, who had avoided acne all his life, died of smallpox. What a travesty.

Kangxi, who later suffered from smallpox, became more aware of the horror of smallpox. He believed that if smallpox was not eradicated, his children might be infected with smallpox in the future.

His father, the eight sons and six daughters of Emperor Shunzhi, among those who died of smallpox before the age of eight were four princes and five princesses, more than half.

Kangxi didn't want his son to make the same mistake again.

Especially after seeing his most beloved crown prince Yin Reng develop acne.

When the prince had acne, Fu Weige, the candidate magistrate, took care of him and was promoted to Wuchang magistrate. Two years later, he was called to Beijing. This Fu Weige later became a key figure in the history of smallpox prevention and control.

Fu Weige knew the art of vaccination - this was an advanced smallpox treatment method at that time.

This folk vaccination method originated in the south, also called the "nose-blowing vaccination" method, first originated during the Longqing period of the Ming Dynasty.

As mentioned above, vaccination with variolation is extremely risky and cannot guarantee 100% success, and may even lead to the death of the patient.

Naturally, it is impossible to risk the princes and princesses for something like this.

In order to master the dosage of variola vaccination, Kangxi once had people conduct experiments. He selected thirty court ladies to "test the poison on themselves."

After thirty palace maids were vaccinated with variola, all of them developed smallpox symptoms without exception, but they were not as severe as the symptoms of direct illness. After observing this for a period of time, the twenty-six palace maids gradually improved until they were fully recovered, while the other four palace maids did not survive. But this was already a great success for Kangxi. Afterwards, Kangxi ordered Fu Weige to start a vaccination experiment among the princes. From then on, vaccination against smallpox for princes was officially established as a system.

Due to vaccination, 20 of the 17 princes born since the 15th year of Kangxi grew up healthy, while only 7 of the previous princes grew up.

With the success of vaccination in the palace, Emperor Kangxi began to promote smallpox prevention work on a large scale, extending it from the palace to the people of the Eight Banners and to the northern borders such as Monan, Mobei, and the Mongolian prairie.

For more than 100 years after that, there was little news about smallpox in the palace. The panic days of the Manchu people running around to avoid acne are over for the time being.

To a certain extent, the success of the "war against acne" ushered in the heyday of the Qing Dynasty. In just over 1661 years from 1697 to 30, the undistracted Kangxi successively pacified the three vassals, captured Taiwan, resisted Tsarist Russia, and pacified Galdan, thus stabilizing the rule of the Qing Dynasty in China.

It is different from the fake "war pox" success of the Qing Dynasty. In the late Qing Dynasty, Emperor Xianfeng almost failed to get vaccinated when he was two years old. Although the imperial doctors carefully treated him to save his life, he was left with pockmarks on his face that could not be wiped away. He became the second "Emperor" after Emperor Kangxi. Emperor Mazi". It is said that Emperor Xianfeng's majestic appearance once frightened Cixi on her wedding night.

What Yang Xian brought this time was to completely eradicate the smallpox virus from the land of Ming Dynasty.

Because vaccination requires a lot of manpower, so when Yang Xian saw Wu Sihai's little eyes that were eager for knowledge, he did not hold back at all and told Wu Sihai the methods and principles of vaccination. .

Empress Ma originally wanted to be vaccinated with cowpox on the spot, but Shangguan Yu'er finally persuaded her to stop.

Shangguan Yu'er wanted to wait until she got the results to prove that cowpox was fine, and then let Queen Ma get vaccinated.

Anyway, everything has already happened, so there is no rush at this moment.

After coming out of the house, Yang Xian looked at Zhu Biao and said: "Your Highness, I am going to vaccinate all the people in the capital with cowpox. Therefore, these dozen cows alone are not enough. Someone must find them." More cows.”

"There's no problem with that." Zhu Biao agreed immediately. He knew very well the importance of all the people in the city being vaccinated with cowpox. This was just the beginning.

Yang Xian then said: "Then I will summon the imperial doctors, no, all the doctors in the capital. I will conduct unified training for them to ensure that the subsequent cowpox vaccination work can be carried out smoothly."

Because it will take time for Shangguan Yuer to get the results.

This period of time is enough for Zhu Biao to do these preliminary preparations.

In order to observe the changes in Shangguan Yu'er's body at all times, Yang Xian spent the past few days with her, so to speak.

The pathogenicity of the vaccinia virus to humans is very weak, and it can generally only reproduce at the site of vaccination. Therefore, pockmarks on the face will not occur due to exposure to human pox. However, because it has strong cross-immunity with the smallpox virus, immunity to the smallpox virus will appear in the human body after vaccination.

On the third day after Shangguan Yu'er was vaccinated with cowpox, Yu'er's body had a primary reaction and red papules appeared locally on her left arm.

On the same day, Zhu Xiongying was finally able to get out of bed and walk.

After so many days, Crown Princess Chang Xia finally saw her son, held Zhu Xiongying tightly in her arms, and cried with joy.

At the same time, she also gave Yang Xian a big gift.

A great gift that transcends etiquette, because logically speaking, as the crown prince, Chang Xia and Yang Xian have a monarch-minister relationship.

At the same time, he said that in the future, whenever Yang Xian asks for anything, not only she, Chang Xia, but the entire Chang family will go through fire and water without hesitation.

This promise is very weighty.

You must know that even if Chang Yuchun is gone, the Chang family still plays an important role in the Ming army.

For Lan Yu to be able to achieve his current status, in addition to his own outstanding military talents, the help given to him by the Chang family cannot be ignored.

On the fifth day, the red pimples on Yu'er's hands turned into herpes, and within two days, they turned into pustules.

During this period, Yang Xian trained batch after batch of professional vaccinia workers.

On the tenth day, pustules on Yu'er's hands formed brown scabs.

Special vaccination stations for cowpox were set up throughout the capital.

After a few days, the scab finally fell off, leaving scars on Yu'er's fair arms, which was a sign of successful vaccination.

Generally speaking, it is natural for women to love beauty since ancient times.

Especially a beauty like Yu'er.

But Yu'er didn't react at all to the obvious scars left on her arms. Instead, she felt a little disappointed because the vaccination was over.

Because during these days, Yu'er was not only able to eat desserts from Mingji every day, but many of her three meals a day were delicacies she had never tasted before. Yang Xian opened a small stove by himself.

This kind of day eating from morning to night is really pleasant.

Yu'er couldn't help but think.

After proving that there was no risk in vaccination with cowpox, Yang Xian began to vaccinate people in the palace, including Zhu Biao, Queen Ma, and a number of princes who had not yet been enfeoffed.

All the chamberlains and maids in the palace were vaccinated by the imperial doctors.

The vaccination station outside the palace was simultaneously vaccinating ordinary people against cowpox.

As the emperor, Zhu Yuanzhang, together with all the civil and military officials of the dynasty, also chose to conduct cowpox vaccination at the vaccination station outside the palace in front of the people of the city.

This is the courage of Emperor Hongwu.

His Majesty the Emperor personally took the lead and set an example, using practical actions to tell the people in the capital that vaccination with cowpox could prevent smallpox.

It also makes this work not so difficult to move forward.

In fact, if Yu'er had not stepped forward, Zhu Biao, as the prince, would have been the first person in the world to be vaccinated against cowpox. Empress Ma also asked Yu'er to persuade her to come back.

The emperor, prince, and queen all planted it.

What are ordinary people afraid of?
This is often the case. When a work or a policy is launched, if you want the people to follow and believe in it, first of all, the people above you must do it themselves. They must give full play to their role of example, take the lead in setting an example, and take the lead. Only in this way can we Let the people believe it.

This is actually similar to the situation of killing enemies on the battlefield. The general who takes the lead can actually lead the soldiers to a greater extent.

Enter the game, take responsibility, lead by example, and set an example for the Ming Dynasty. (End of chapter)