top student at medical school

Chapter 812 The Boss and the 'Little Boss'

"Principal Zhang, Principal Yuan, what brings you two here to see me? I'm quite flattered," Fang Ziye chuckled.

Seoul University has many colleges, but the medical school and affiliated hospital are not its strengths; in fact, they somewhat hinder the university's overall performance.

Although Fang Ziye is doing well in the medical field, he doesn't deserve to be personally noticed and 'inspected' by Principal Zhang Pingwen!
In the school, there are quite a few people with projects that are bigger and more important than those done by Fang Ziye, and there are even some classified projects.

Yuan Yufeng replied, "President Zhang has always paid attention to the development of our medical school and clinical college, and the development of the medical school and clinical hospital has always been a slightly emphasized direction of our school's development."

"Principal Zhang, this Professor Fang Ziye can be said to be one of the best among the three clinical colleges of our school. He was previously promoted to associate professor and associate chief physician by the National Health Commission without meeting the usual requirements..."

Upon hearing this, Zhang Pingwen slightly raised his hand, indicating to Yuan Yufeng that there was no need for further introduction: "Professor Fang, I know you are quite busy, so I won't beat around the bush."

"Actually, I received a research call about you from above the day before yesterday. I was delayed by something yesterday, so I thought I had to come and see you today."

"It's better to ask about these things face-to-face."

"Is the project proposal you privately passed to the National Natural Science Foundation of China genuine or fake?"

"This is no small matter."

After speaking, Zhang Pingwen even took out a document from his briefcase—

"my country's generic drug industry is large but not strong, lacking innovation capabilities. Furthermore, there are almost no generic versions of targeted drugs in the Chinese market, which means there is no competition and the prices of targeted drugs naturally cannot come down."

"Because the early approved generic drugs had relatively weak medical research foundations, the quality of some generic drugs was significantly different from that of the original drugs, and they could not yet achieve the clinical effects of the original drugs."

"To improve the quality of generic drugs, my country has issued the 'Work Plan for Consistency Evaluation of Generic Drug Quality (Draft for Comments),' which proposes to complete the consistency evaluation of some varieties by 2014, basically complete the consistency evaluation of all solid oral dosage forms by 2015, and carry out consistency evaluation of injectable drugs and other dosage forms from 2015 to 2020..."

After handing the document to Fang Ziye, Zhang Pingwen took out another document.

The above is the news content published by Xinhua News Agency.

Generic drugs that enter the domestic hospital centralized procurement system must pass the "consistency evaluation" by the National Medical Products Administration.

In theory, drugs that have passed the bioevaluation test should be largely bioequivalent to the original drugs. However, bioequivalence does not equate to clinical equivalence. Clinical feedback indicates that some drugs that have passed the bioevaluation test still differ from the original drugs in terms of absorption and efficacy.

Drug crystal form is the crystal structure formed by drug molecules arranging themselves in a certain regular pattern in the solid state.

Different crystal forms of the same drug may have significant differences in appearance, solubility, melting point, dissolution rate, and bioavailability, thus affecting the drug's stability, bioavailability, and efficacy.

...Some generic drugs with slightly lower absorption and utilization rates can achieve the same therapeutic effect by increasing the dosage, but the absorption curve will be different from that of the original drug.

The quality standard of generic drugs is a range indicator, such as 95%-105% is considered qualified. The original drug may achieve 102%, and domestic pharmaceutical companies may achieve 97%, all of which are within reasonable limits. However, the reasonable differences generated by each item will become larger and larger after multiple items are accumulated.

If we say that ten years ago (before the implementation of the consistency evaluation system), most domestic generic drug companies could only score 20 points, and a few could reach 60 points, then after the implementation of the consistency evaluation system, the vast majority of companies can reach more than 60 points, and there are hundreds of companies with scores of 80-90 points.

After highlighting the key points, Zhang Pingwen said, "Professor Fang, you are a doctor, you should know that there is a huge difference between a drug that scores 95 and a drug that scores 100!"

"And you? When you submitted your project proposal to the National Natural Science Foundation of China, you described the clinical therapeutic efficacy, not the biological efficacy."

Biotherapeutic efficacy is determined through animal testing, while clinical efficacy is assessed by evaluating the effects on actual patients after application.

Fang Ziye nodded, but his tone was one of surprise: "Principal Zhang, you can still send my project proposal to me?"

Fang Ziye's current scientific research achievements and medical projects are quite impressive. Last year, the National Natural Science Foundation of China made a special trip to Enshi to register and approve Fang Ziye's research projects.

Then, Fang Ziye was given some special 'privileges', such as being able to contact them at any time when there were important topics.

The National Natural Science Foundation of China has a dedicated medical office, which also needs to demonstrate its capabilities and wants to invest funds in clinical researchers who are more capable of producing results.

Zhang Pingwen was puzzled: "Professor Fang, if you have such ability, why don't you go and develop innovative drugs instead of getting involved in the murky waters of generic drugs?"

"Won't this distract you a lot?"

It's not easy to figure out how to make generic drugs reach the level of original drugs.

If generic drugs can be made to make money, don't pharmaceutical companies know how to do it?

However, the production process of genuine drugs is a trade secret and cannot be disclosed. What is disclosed are the crystal form and preparation mode, which give you a lot of room for adjustment and a very high trial-and-error rate.

Achieving a 70-80% cure rate is already quite difficult!
Fang Ziye would certainly not say that pharmaceutical preparation processes are definitely unrelated to medicine, but clinical efficacy is related to medicine.

Fang Ziye possesses the most amazing skill of Level 7 basic medical research, which allows him to maintain unlimited "innovation" capabilities.

Fang Ziye replied, "Principal Zhang, there is a concept we must understand: the drug content is not directly related to the therapeutic effect."

“Drug combination therapy, drug combination, prescription modification, and formulation are the factors that are most closely related to clinical efficacy.”

"Of course, an even stronger reason is that generic drugs are simple; there are existing systems that can be used immediately."

"Aside from the lack of scientific research output, its practical significance is still enormous."

Zhang Pingwen wasn't so easily fooled. After a quick glance, he smiled calmly and said, "Professor Fang, is it because you didn't agree to work in Kyoto that you've given up on career advancement?"

Even at Seoul National University, the number of candidates eligible for academician nomination each year is not large!

Zhang Pingwen was naturally very concerned.

Even the reasons for failing to pass the evaluation must be carefully examined and considered.

Once Fang Ziye is reported, the feedback that comes back will be followed up by a dedicated person.

Fang Ziye smiled and said, "Principal Zhang, you can't say that."

"I'm already doing very well. Let's not talk about progress. Han City University can definitely accommodate an associate professor like me who no longer produces anything, and Zhongnan Hospital can also accommodate an associate chief physician like me who can still make a living based on my abilities."

"My salary is alright, I won't starve or freeze."

"I already have a car and a house, I'm just a country bumpkin, what else do I need to strive for?"

Yuan Yufeng listened silently.

He's currently pursuing an administrative career, so it won't be easy for him to take that next step.

However, if an academician can emerge from Zhongnan Hospital, he will also feel proud.

Zhang Pingwen replied, "The more understated it is, the more it means that Professor Fang is bothered by it."

"You're still young, you have a long future ahead of you, there's no need to give up on anything because of this..."

"Professor Fang, you can now be considered a pillar of the surgical research field at Zhongnan Hospital. If you have any difficulties or ideas, you can communicate more with Principal Yuan."

Fang Ziye shook his head: "No, no, Principal Zhang, you misunderstood me. I didn't say that I would give up anything."

"All my research is proceeding normally!"

At this point, Fang Ziye added, "Now that Principal Zhang has brought it up, and Principal Yuan is here as well, I do have some questions I'd like to discuss with Principal Zhang and Principal Yuan."

"Currently, we have a high level of expertise in some surgical procedures, but the speed at which we can apply our knowledge is still too slow."

"If we want to extend the surgical procedures that our hospital routinely performs to prefecture-level city hospitals, it will take at least 20 to 30 years. And if we want to extend them to county hospitals, we don't know how long that will take."

"Given this situation, I do have a preliminary idea: to establish a teaching team, using our orthopedics department as a pilot, to study how to simplify surgical procedures so that more people can learn and perform them in clinical practice."

"Just like our previous limb-sparing surgeries for traumatic injuries, our team has gained some simplified experience, and now it can be performed with some difficulty in prefecture-level city hospitals. But we can offer more teaching projects like this..."

Yuan Yufeng has a medical background, and although he is the vice principal, he has not completely withdrawn from clinical practice. Hearing this, he was slightly surprised: "Professor Fang, you still want to start such a large-scale teaching project?"

Do you have that much energy?

"The reason why Principal Zhang came to see you this time is to have a good talk with you about future plans and development, and also to hear about some of the development goals of the Department of Surgery at Zhongnan Hospital."

Yuan Yufeng was practically making it clear.

Why are you talking about your spinal cord injury research, your bone tumors?
Fang Ziye smiled and said, "Principal Yuan, it should be possible to spare this much energy." "The significance of scientific research lies in solving practical problems. Now that we have identified the practical problems we are facing, we should find ways to solve them."

"My energy is currently limited. Apart from continuing to develop new treatments for diseases, I only dare to think about some generic drugs and a small number of simplified surgical procedures for teaching purposes."

"I feel that if I can do all of these things well step by step, then I will not have wasted the trust and care that the school, the hospital, and even the National Health Commission have placed in me!"

Everyone looks out for themselves! Heaven and earth will punish them!
Being poor cares themselves, being wealthy cares the world.

Fang Ziye used to be extremely poor. He even borrowed money from his fellow students and traveled around to earn money for research projects and competitions.

At that time, Fang Ziye's abilities were average and his skills were limited. If he were to say that he cared about the common people, that would be a joke.

Fang Ziye's current abilities have reached an incredible level, and he has achieved initial financial freedom. He won't starve, but his previous aspirations have been dashed. The Nobel Prize is out of reach for him. So what can Fang Ziye do?
If you can't act for yourself, then think about acting for others!
Fang Ziye isn't that lofty and aloof; he never sets a high standard for himself, but he does have his own unique way of "lying flat"!
"Principal Zhang, could it be that the National Natural Science Foundation of China has rejected my project as well?" Fang Ziye asked, squinting.

Zhang Pingwen was annoyed when he heard this: "Rejected? Who dares to reject your research project? You've really walked into a trap."

"You are a clinician yourself, don't you know how big the deficit is in your medical insurance system?"

"Why do you need me to analyze the fundamental reasons for reforming the healthcare system?"

"The medical insurance budget deficit is serious, and the income cannot cover the expenditure, so we can only tighten our belts to make ends meet."

"In this kind of environment, you put forward such a topic, and it's just a matter of time before it's officially decided. You're taking on a label that others would avoid at all costs."

"I've come to you this time to offer you a way out. Come with me to Kyoto and we'll get this project proposal back."

Zhang Pingwen's tone was quite impolite.

It wasn't that he looked down on Fang Ziye or thought Fang Ziye lacked ability; he just felt that Fang Ziye was a bit too aloof and arrogant.

Why are you so discouraged by one failure?

How old are you?

He's not even thirty-five yet; he has a long road ahead of him.

Fang Ziye was relieved and gently shook his head: "Principal Zhang, it's good that it wasn't rejected. I thought mine was rejected too."

“Professor Fang…” Zhang Pingwen hesitated before speaking.

Upon hearing this, Yuan Yufeng said, "Principal Zhang, how about I speak with Fang Ziye alone again?"

"It's best to be cautious about this matter."

Fang Ziye continued, "Principal Yuan, Principal Zhang, would you two like to hear something from me?"

Zhang Pingwen was taken aback upon hearing this, then nodded.

……

Half an hour later, Zhang Pingwen and Yuan Yufeng walked out of Fang Ziye's director's office with strange expressions, their faces showing an indescribable "excitement" and "conflict"!
"Principal Zhang, Principal Yuan, I have surgery later, so I won't see you off any further," Fang Ziye said with a smile as he accompanied the two to the ward door.

Zhang Pingwen turned his head, his expression shifting again: "Professor Fang, should I say you have lofty ambitions, or should I say you're unique?"

Fang Ziye replied, "Principal Zhang, my former mentor once told me something like this: if a person doesn't even dare to dream, then the upper limit of their life will be fixed."

"People have to dare to think about things."

"Mayo Clinic also started as a small clinic, but the platform I'm relying on now is quite large."

Yuan Yufeng lowered his voice: "Every hospital wants to be like Mayo, but there is only one Mayo in the whole world."

Both Zhang Pingwen and Yuan Yufeng felt that their skill level was too low.

Compared to Fang Ziye's ideas, their plans and ideas were too simplistic, too vulgar, and too lowbrow.

"Before Mayo came along, nobody knew that Mayo would become the Mayo Clinic it is today."

“Teaching projects must be prioritized, and our clinical team and our hospital must have reliable drugs.”

"Policies must keep up, and scientific research must also move forward!" Fang Ziye said.

"Other things are nice to have, but if they're not there, it doesn't really matter."

"I'm young anyway, and I'm not afraid of looking bad. Even if I don't succeed in the future, I'll just be labeled as young and impetuous. I'm only thirty-two years old now."

"Right? Principal Zhang?" Fang Ziye grinned shamelessly.

I said I wanted to build Zhongnan Hospital into a top-tier institution similar to the Mayo Clinic. So what? Who dares to say that I shouldn't say such things at my age?

Those elementary school students dare to dream of becoming scientists and astronauts, so why are you criticizing them for being unrealistic?
When kids act like hooligans, they do it with complete righteous indignation!
Zhang Pingwen and Yuan Yufeng immediately bypassed Fang Ziye and went downstairs via the stairs.

Fang Ziye did not follow, clearly indicating that the two had something to say.

“Principal Zhang, please don’t take Fang Ziye’s words seriously. He’s just…” Yuan Yufeng said.

Zhang Pingwen glanced at Yuan Yufeng: "Why can't we take it seriously? Just because he thinks he's just a child speaking without thinking, does that mean he's really speaking without thinking?"

"Do you really need so many reasons to invest in an associate professor? He doesn't ask for much, of course you should give him the job!!"

"Investing in research funding is nothing but gambling!"

Zhang Pingwen's vision is much broader than Yuan Yufeng's!

Yuan Yufeng was speechless upon hearing this, and even wondered if his brain had become rusty and he was out of touch with the times.

“Principal Zhang? You agreed? You didn’t come here to persuade Fang Ziye…” Yuan Yufeng asked.

"I came here to persuade them, but now I've been persuaded. What's there to be ashamed of?"

“If I try to persuade him, he has to listen; that’s an order.”

"Fang Ziye's antics are not serious enough to cause trouble and waste money. I don't need to order him to stop doing anything and to obey orders!"

"We dare to think and act, we have a foundation, we have development, we have plans, we have a future, a higher future, and we have a roadmap."

"If you won't even invest in this kind of thing, then what's the point of investing at all?"

“Give it to him.” Zhang Pingwen set the tone.

Fang Ziye didn't ask the school for much.

It was mainly Fang Ziye's words that moved Zhang Pingwen!

Is the real advantage of the Mayo Clinic that their doctors are more skilled than those in China?

it's not true!

There are certain factors that elevate their procedures, which may result in better treatment outcomes than those of top professors in China.

This includes, but is not limited to, equipment, drugs, research accumulation, and understanding of basic research.

To succeed in any endeavor, one must first have the right tools!
Yuan Yufeng muttered, "A teaching research topic? How do I submit it?"

"Isn't this just asking me to offend people? The school doesn't have to pay for this, and you, Zhang Pingwen, just agree to it without hesitation, leaving us to handle it internally?"

"Who would willingly become a puppet of Fang Ziye's teaching projects, only to simplify clinical procedures in the future? And abandon clinical work altogether?"

However, Yuan Yufeng only dared to mutter these thoughts to himself and did not dare to say them aloud.

Just as Fang Ziye was about to enter the operating room, his research assistant, Han Jingyi, said, "Professor Fang, there's a message in your email from a foreign professor who wants to visit Wuhan again and says he wants to know you. Could you please take a look at the message when you have some free time?"

(End of this chapter)