When I am reborn, I just want to be a top student

Chapter 476 released, horrible box office

It has been more than four years since I was reborn.

These four years have different meanings for different people.

For Wang Donglai, these four years have been far more exciting than his previous life.

He was the top scorer in the college entrance examination, highly sought after by all universities, an academic rising star, he shocked the global mathematics community, won internationally renowned awards, founded a company worth hundreds of billions, was elected as an academician, and gained both fame and fortune.

The most important thing is that Wang Donglai accomplished all these when he was still young.

With a psychological age of nearly thirty and social experience, Wang Donglai has taken a path that most reborn people would not take.

Wang Donglai doesn't dare to say how much influence he has on the world.

However, it did have some impact to some extent.

For example, the early rise of domestic smartphones and the explosion of the new energy vehicle market.

For example, China announced the closure of all P2P platforms across the country, which was several years earlier than originally planned in history, thus avoiding a long detour and countless mistakes.

For example, Wang Donglai's advanced packaging design solution has promoted the level of domestic semiconductor technology and mastered the 28nm chip process earlier.

These are just the things that can be found on the surface.

In secret, Wang Donglai has made a lot of contributions. For example, in the South China Sea incident in July, it was thanks to Wang Donglai's algorithm program that the military communication code of the Bald Eagle was cracked, thereby finding the location of the Bald Eagle's aircraft carrier and forcing the Bald Eagle to retreat.

This achievement will definitely not be made public, but the higher-ups will not forget it.

now.

The reason why Wang Donglai is preparing to launch the Evergreen Liquid is because of this.

Now he has the energy to keep the Evergreen Liquid, a golden goose that lays eggs.

Even if he comes up with more disruptive products in the future, he won’t have to worry too much.

Previously, Wang Donglai told Zhang Bytedance, Zhou Rui and other senior executives of Galaxy Technology that Changqing Liquid was developed by the company's research laboratory, which was actually a lie to them.

The research and development of a new drug takes an average of 12 years, from the final laboratory research to the final market launch. On average, it costs 66 billion Chinese yuan, 6587 experiments, and 423 experimenters to finally get a drug.

There is also data showing that in the 1997 years from 2011 to 50, the average R&D cost of each new drug by internationally renowned pharmaceutical companies was around US$ billion.

Just like the drug 'Gleevec', the prototype of 'Gleevec' in the TV series "Dying to Survive", it took Swiss company Novartis 2001 years and an investment of more than 50 billion US dollars from the discovery of the target to its launch in 50.

From 1997 to 2011, Novartis invested $836 billion in new drug research and development, of which only 21 drugs were approved for marketing, with each new drug costing an average of $40 billion.

It is no exaggeration to say that the birth of a new drug, completely from scratch, is more difficult than winning the jackpot in the Chinese lottery.

From the initiation of a new drug project to the launch of the product, the success rate is less than 2%, and other projects will naturally lose all their money.

The process from research and development to the marketing of new drugs includes preclinical drug research (drug synthesis methods, extraction methods, physical and chemical properties, purity, dosage form selection, prescription screening, preparation process, inspection methods, quality indicators, stability, pharmacology, toxicology, and pharmacokinetic research, etc.), application for clinical trial approval, clinical trials (including bioequivalence experiments), new drug application, obtaining new drug certificates and drug approval numbers, drug production, and post-marketing testing.

This process is complicated and tedious, and there must be no mistakes in every link, otherwise all the previous efforts will be wasted and the invested money will be wasted.

First of all, the first thing to do is to find new compounds with potential, which takes two or three years, which is like looking for a needle in a haystack.

The next step is to identify the target and synthesize compounds. During this process, researchers need to create thousands of new synthetic compounds and then screen them. Among approximately five thousand new synthetic compounds, generally only five at most can enter clinical trials, and in the end only one can be approved for clinical treatment of patients and become a real drug.

The clinical trial approval process is complicated and involves many departments. It requires the approval of multiple departments, so the difficulty can be imagined. The failure rate at this step is about 90%.

After passing the above difficulties, it is time for clinical trials, which will take another 3 to 7 years and are divided into Phase 1, Phase 2, Phase 3, and Phase 4. They are mainly to confirm and reveal the effects, adverse reactions, and absorption, distribution, metabolism, and excretion of the experimental drugs, in order to determine the efficacy and safety of the experimental drugs.

After passing this hurdle, we cannot be careless, as we will need to face new drug approval next.

Even if in previous experiments, the new drug was found to be very effective and without any problems, it still could not be easily passed.

If the application fails to be approved, all previous efforts will be reset to zero and all investment will be wasted.

The approval of new drugs is the most rigorous and time-consuming of all processes. When submitting a new drug application, all the scientific information that can be collected must be provided. How much material is there?

Over 100,000 pages!
If there are too many materials and some parts are not standardized, the approval time will be longer.

Even if a new drug passes approval by chance, it still needs to face supervision after it is launched on the market.

If serious adverse reactions are found that were not discovered in the research, the new drug will still be forced to be removed from the shelves.

It is precisely because the new drug research and development cycle is long, the risk is high, and the investment is huge that bankruptcy can occur if you are not careful.

Therefore, the number of domestic pharmaceutical companies that dare to develop new drugs is so small that it is frightening.

It is precisely because of this that our country has become a barren land for new drug research and development.

Apart from Tu Aoao's artemisinin, there is no other internationally recognized new chemical drug.

In 2013, the Tufts Center for Drug Development Research released a statistical data that the R&D investment of the top ten pharmaceutical companies in the world accounted for 17.8% of their sales, reaching US$603 billion, while the R&D investment of the top ten domestic pharmaceutical companies was only 1% of their sales, about US$3 million.

Anyone who understands knows how much water there is in this 1% of drug development.

However, data from 2015 showed that 95% of my country's chemical drugs were generic drugs, and even among them, the quality was not optimistic.

So, facing this domestic situation.

In fact, it is no wonder that Huang Zheng, Zhang Bietian and others expressed doubts about the Changqing Liquid that Wang Donglai brought out.

Wang Donglai knew this a long time ago, so he had already thought of a countermeasure.

That is to push research and development into the laboratory.

With Wa here for the specific data, you don’t have to worry about it at all.

No matter who checks it, it is flawless.

The emergence of Evergreen Liquid is not accidental.

Wang Donglai had acquired two magical skills before.

【Cheat Code】

【Alchemy】

These two magical skills are absolutely an extremely terrifying boost to Wang Donglai.

After acquiring these two skills, Wang Donglai was not in a hurry to show them off.

But it is accumulating silently.

Changqing Liquid is one of the results.

Now, he thinks the time has come, so he came up with the product Changqing Liquid.

In the office, Wang Donglai muttered to himself, then opened the system panel and checked his information.

[Player: Wang Donglai]

[Attributes: Physique 11, Wisdom 11]

【Occupation: Scholar, Businessman】

[Level: Level 42158 (50000/)] [Reading Type: High School Compulsory, Computer, Economics, Physical Education]

[Skills: Photographic Memory, Brain Overclocking, Insight, Celestial Phenomena, Teaching, Living Mentor, Golden Finger, Alchemy]

[Abilities: sense of direction, speed reading, mental arithmetic, language proficiency, political strategy, genius student, memory palace]

【学科】:数学lv8(58467/1000000)、语文lv7(14241/30000)、英语:lv7(12142/20000)、地理:lv7(10258/20000)、政治:lv7(10010/20000)、历史:lv7(11154/20000)、化学:lv6(14758/30000)、物理:lv6(14975/30000)、生物:lv6(13472/30000)、计算机:lv6(28457/50000)、经济学:lv6(31485/50000)、体育:LV6(8451/30000)

[Main Mission: Business Empire]

[Business Empire: It is detected that the player created a company and starts this task. The task rewards are based on the market value of the player's company. The higher the market value, the heavier the reward. 】

[Progress: Market value exceeds 100 billion]

[Side mission: Attack of the top students! 】

[Attack of the Academic Master: Knowledge is the ladder of human progress, and books are the carrier of knowledge. Players can get one point for every one hundred books they read. 】

【Progress: 51470】

[Available points: 21]

Read more latest popular novels at 6.9*shuba!

Looking at his system panel which had not changed much in a long time, Wang Donglai frowned slightly.

He has indeed been neglecting the system and his own data growth recently.

However, this is mainly because I have pushed each subject to a relatively high level, making it more difficult to upgrade. It is no longer a simple matter to upgrade again.

After analyzing his panel information in detail, Wang Donglai closed the system panel.

……

soon.

"Dying to Survive" has passed the approval of relevant departments and has been officially scheduled.

Because of Wang Donglai's instructions, the plot of the movie has changed, becoming more realistic and more dramatic.

It did not choose the prime time period, but instead chose to release it on a weekend nearby.

Originally, people in the theaters were not very optimistic about this movie and did not pay much attention to scheduling the screenings.

However, in order to achieve results, the people below finally decided to start advance screenings and invite film critics, theater managers and other relevant people to watch.

At the same time, all platforms under Galaxy Technology also tacitly promoted "Dying to Survive".

For example, Douyin, Neihan and Toutiao.

As the movie trailers and promotional clips were released as a warm-up, it immediately sparked a small discussion online.

After all, Galaxy Technology still has a certain reputation online.

However, after seeing the released content, the amount of attention and discussion online gradually increased.

"Whose family doesn't have a sick person? Can you guarantee that you won't get sick in your life? If you catch him, we will all die. I don't want to die. I want to live. Okay?"

Among them, the most popular video is the one in which this sick old lady with gray hair, looking haggard and exhausted, says these lines.

The lines are touching and the actors' acting skills are superb.

The patient's helplessness, pain and pleading are portrayed vividly.

As a result, the movie "Dying to Survive", which has not yet been released, became a small hit.

"As a medical student, I dare say that this movie is the most explicit in recent years in China!"

"This movie has a great entry point. I checked and it seems to be based on real events. I am looking forward to it and will bring my family to buy tickets to support it!"

“I can’t say much more. I can only say that Galaxy Technology is awesome. They even dared to invest in and release a movie like this.”

“I strongly recommend everyone to watch this movie once it’s released!”

Comment after comment promoted "Dying to Survive" online, acting as a tap water and further pushing the popularity of the movie to a new level.

soon.

Movie releases.

On the first day of its release, the box office exceeded 200 million!
You have to know that this was the film market in 2016, and there was actually a movie with a single-day box office of million.

This result immediately shocked the entire entertainment industry.

All the actors and crew members involved in this movie became extremely excited as if they had been injected with chicken blood.

Especially the actors who had more roles, they promoted the film very actively, and even bought some internet trolls for the film, hoping to increase the popularity of the film.

With the explosion of box office, the online reputation is even more amazing.

"There is only one disease in this world, and that is poverty. This is a very good saying!"

"Having a disease but no medicine is a natural disaster, having medicine but no money is a man-made disaster. After watching the movie, I suddenly realized the true meaning of money. Only by making money can I let my family live a good life, wear nice clothes, eat delicious food, and get the best treatment and the best medicine when I am sick."

"It's really hard to imagine that the plot in the movie actually has a real case!"

"I cried several times in the cinema. I couldn't hold back my tears as a grown man."

“I will recommend this movie to my friends and ask them to watch it!”

"I'm suddenly a little worried now. I'm afraid that this movie will be banned tomorrow. It's unimaginable that such a large scale movie could be put on the screen!"

All platforms were flooded with comments about "Dying to Survive".

It is not the same old tactic used by internet trolls, but is truly inspired by the author's feelings.

Medical, health.

This is something that many people are concerned about and is closely related to everyone.

Seeing the plot in the movie, the audience was easily drawn into it.

Looking around the country, only a handful of families can afford this medicine, which costs RMB 40,000 per bottle.

Ninety-nine point ninety nine percent of families who encounter such a disease can only hold on for a period of time and then wait for death.

This further amplifies the audience's empathy.

I subconsciously began to worry, what should I do if I, my family or relatives got such a disease?
In reality, this means strong recommendation and support for "Dying to Survive".

So, even if it’s not a prime time, it’s just an ordinary weekend.

The movie box office showed no sign of slowing down, but instead rose against the trend.

As the box office of "Dying to Survive" continues to grow, the amount of social discussion grows, and word-of-mouth spreads faster and faster.

Soon, it attracted official attention. (End of this chapter)

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