Rebirth 07: Start adding points from elementary school students

Chapter 551 Universal Medicine

Mr. Tan almost slapped himself. He felt like he was dreaming.

Although the universal special medicine is indeed a project they are promoting, even He Xiaogang, the most capable and famous partner, has the most positive attitude towards this research, that is -

"I hope our research can provide some inspiration to future generations, or help them find some wrong routes."

It can be said that from the beginning to the end, no one thought that the "universal panacea" would be a research project that would produce results.

It’s just that Li Yan really has too much money, and this is not the only research project he has invested in regardless of cost, so no one thinks too much about it.

Now you suddenly say you want to “conquer it with all your might”?
Mr. Tan didn’t understand. He could only think that Li Yan wanted to make the project in which his girlfriend Wei Yunzhi participated more... prominent?

No matter how you look at it, it doesn't seem like something someone like Li Yan would do.

But considering that grand fireworks show... Well, the boss is also a passionate person, and sometimes he gets carried away.

In any case, he still has to patch it in advance:
"Mr. Li... a universal cure-all. No, let's not talk about that. It's his subordinate research, broad-spectrum cancer therapy. Our current progress... is just organizing the ideas."

Liu Zimei swallowed his saliva and looked at Tan Sheng who was so nervous that he was sweating. He didn't even dare to look at Li Yan.

"I know." Li Yan's answer was unexpected. "It just so happens that you are all here, let's chat. I know the idea, and I want to hear about the progress of the experiment."

"In the direction of cancer-specific recognition, we are trying to promote multimodal targeting systems. At present, we are preparing to use nanosymbiont ANP shell-modified bispecific antibodies for surface marker recognition. The experiment has preliminarily verified the signals represented by different reactions. However, the practical application of nanosymbionts... is still far away."

Mr. Tan did have something in mind, as he was able to answer such a sudden question in a clear and logical manner.

"continue."

But it would be troublesome to continue. Tan Sheng sweated even more and looked at the other three technical backbones for help.

"Well, we have found some evidence, such as some experiments on dual antibody targeting strategies... Regarding specific recognition, we have also conducted physical property response experiments. EPR effect optimization should also be a direction..."

"By utilizing the enhanced permeability and retention effect of tumor tissue, 50-100nm particles are preferentially enriched," Liu Zimei added.

Mr. Tan gave her a grateful look.

"There is also metabolic characteristic perception, and ANP has a built-in lactate sensor." He Ziwen also got into the state.

Several people discussed the idea of ​​specific identification.

Li Yan sighed.

The scene suddenly became quiet, with only some breathing sounds being heard.

Li Yan took a sip of water and said, "I'm not here today to listen to your ideas and how much you have done. I'm not testing you, so don't take credit for it."

Tan Sheng's sweat was about to drip into his eyes. Liao Jun handed him a piece of paper, but he didn't even look at it.

"Mr. Li, I understand. Please give me some time to summarize."

"I didn't ask you to memorize this stuff."

Mr. Tan nodded again quickly, "Yes, yes, please wait a moment, I..."

Liu Zimei quickly handed over the tablet and left an expression that said "You have to thank me very much."

"It's like this..." Tan Sheng just opened his notes and was about to speak, but was immediately interrupted by Li Yan:
"I didn't say you were wasting my time standing here."

"Okay, please give me a few minutes."

"You can discuss it."

"Okay, okay..."

After six minutes, Mr. Tan stopped He Ziwen and Liu Zimei from discussing fiercely in low voices and raised his hand:

"Boss Li, I can report now."

“We are discussing.”

"Okay, I can discuss it."

Li Yan didn't know whether to laugh or cry, and waved her hands, "Go ahead."

"I will not elaborate on the specific recognition I just mentioned. The nanorobots are still in the experimental stage and are still far from practical application. In the specific drug delivery stage, we are currently feeding data to the AI, hoping to directly predict the distribution of tumor heterogeneity through training with patients' circulating tumor DNA sequencing data, and output the optimal drug delivery route. The progress of this step is in cooperation with Star Technology to develop a large model."

"continue."

Tan Sheng is more confident. "In terms of multi-mechanism synergistic treatment, epigenetic resetting has been regulated. Experiments have shown that cancer stem cell differentiation markers are upregulated and tumorigenicity is reduced. Several current ideas have certain experimental support, including but not limited to generating free radical oxidation inhibition markers, inducing chromatin opening, and correcting TP53 mutations... This is too detailed. Let me summarize it. In short, it is not difficult to prove the effectiveness of each regulatory idea, but how to connect this idea to formal treatment... I don't have any idea yet."

"continue."

"In terms of metabolic shackles, the effect of engineered microbiota has been verified, and synthetic microbiota does have a gratifying effect in resisting tumors. There is sufficient data support that D-2HG dehydrogenase degrades carcinogenic metabolites produced by IDH mutations, and glutamine analogs effectively block tumor glutamine metabolism."

"You only did these two?"

Li Yan's question made Tan Sheng, who was full of confidence, lose confidence again.

"Well... because the idea of ​​synthetic bacterial flora is only recently coined, and the experimental indicators are difficult to capture and the cycle is a bit long, we actually tested more than a dozen options, and in the end only these two were effective." He Ziwen added.

"For a semi-exhaustive approach, it's considered very lucky to have two feasible results out of a dozen tests," Li Yan said, his expression unclear. "What about the synergy of the nano-symbiont?"

Tan Sheng was stunned, frowned and looked at Liao Jun, Liao Jun also frowned, "Mr. Li, this... we haven't tried it yet, it seems that Academician He Xiaogang has basic experiments."

"continue."

Later, with the support of three backbone members, Tan Sheng summarized the design basis and related experimental conclusions of the immune panoramic activation, metastasis and recurrence defense system.

Compared to the previous content, there is even less to say about these two experiments.

Both CAR-T cell transformation and macrophage reprogramming involve genetic programming, which is inherently very difficult. Just completing the operation is enough to make them happy for a long time. How could they be used directly as experimental tools?

By the time he finished speaking, Tan Sheng was already sweating profusely, and he seemed to understand the purpose of Li Yan asking him to say these things.

"Any ideas, Mr. Tan?"

"Mr. Li, I can only say that ideals are full of hope, but reality is very skinny."

Li Yan nodded, stood up and walked towards them. "That's right. The correctness of many ideas has not been verified at all. The greatest achievements come from exhaustive efforts. Although operations such as inhibitors blocking proliferation signals can be considered achievements, as long as there is no idea for the path of 'drug administration', everything is just castles in the air."

"correct."

"And you, as the representative of Future Technology's bioscience business, how could you not even know the progress of the experiments at the Bioscience Research Center?"

Mr. Tan lowered his head and said, "I'm sorry, I didn't follow up in time..."

"At this rate of progress, we won't get the desired results even if we give it another 100 years."

"So, Mr. Li," He Ziwen whispered, "what do you mean by... conquer?"

"Literally. I want to develop a cure-all drug. At least, one that cures cancer."

"How long?" He Ziwen was determined to play the role of a young man. "About half a year to a year."

Tan Sheng's breathing suddenly became disordered.

What?! Half a year to a year?! Is this a joke?

Without caring about the question of face or not, Mr. Tan simply shook his head and said:
"Mr. Li, I'm afraid we'll disappoint you. We really don't have the confidence to do this."

"This is not a question of whether or not you have confidence." Li Yan said with a smile, "Can you do it if you have confidence?"

Mr. Tan was confused, and the other three were also confused.

"I will personally lead the team for this project."

Upon hearing this, Mr. Tan breathed a sigh of relief.

It’s not that he thinks Li Yan’s joining means that this problem can be solved, but if the boss leads the team personally... the so-called time limit will not be too stressful.

Being both a referee and an athlete, what is there to be afraid of?

"Are you confident?"

"……Have."

Obviously, no. As for "finding a universal panacea", they would not have any more confidence just because Li Yan is leading the team personally.

After all, the people involved in the project never thought that this thing would succeed.

Ideas are ideas, but the current experimental basis can be said to be less than one percent of the amount. The cost of trial and error is staggering, and some key technologies cannot even find a breakthrough route. We have the power but nowhere to use it. What should we do?
Also lacking confidence are the top researchers in the entire Life Sciences Research Center, including Academician He Xiaogang.

He was also very surprised that Li Yan was personally leading this project.

Because Li Yan has created many miracles, whether it is operating system, mobile phone or lithography machine, they were all made suddenly in a very short time.

Therefore, Li Yan’s personal leadership of the team will indeed make everyone have some unrealistic fantasies.

Could he really do it?

But it's just a thought. Compared with the fantasy-level achievement of a universal panacea, everything Li Yan had done pales in comparison.

However, when every project starts, everyone thinks it is impossible.

It was with this kind of conflicted and twisted mood that He Xiaogang cooperated with Li Yan to carry out various experiments.

It can be said that in the entire Life Science Research Center, there are only two people who believe that they can really develop a universal panacea.

One is Li Yan and the other is Wei Yunzhi.

Since the end of 2015, Li Yan has been almost immersed in the Life Science Research Center for more than half a year.

This was something no one expected.

He Xiaogang and other bigwigs from BGI-Linda who were collaborating in the Life Science Research Center were all extremely shocked by this.

They couldn't understand how a young tycoon with a net worth of hundreds of billions, a man who was decisive in everything he did, and a man who directly denied the tokamak device as soon as he was recruited by the Institute of Controlled Nuclear Fusion, could have the patience to study an illusory universal panacea for so long.

Therefore, everyone who knew the situation began to look forward to Li Yan's research.

Both excited and scared.

If this could really be accomplished, it would be an astonishing achievement in one’s lifetime.

But if this were really done... the impact would be so huge that it is hard to imagine.

Of course, Li Yan's research also alarmed the authorities, but the project was too professional, and Li Yan had not announced any progress to the public, so they had no idea what was going on.

After all, even He Xiaogang himself, as a top boss in the field and a personal participant, has been experiencing repeated changes in his mentality.

Because Li Yan's behavior was too willful.

There are results. Basically, all experiments conducted according to Li Yan's ideas can be regarded as a kind of data support.

But all of them are "according to Li Yan's ideas."

Therefore, the success of this futuristic project actually depends on whether Li Yan’s ideas are correct.

He Xiaogang knew that Li Yan was a genius, and he also knew that he had done this in his previous projects, but in scientific research, all ideas should have sufficient analysis and support.

Flashes of inspiration are essential, but you can't rely entirely on flashes of inspiration.

In their eyes, Li Yan's behavior was as willful as playing a game.

Li Yan provided ideas, Li Yan provided experimental methods, Li Yan personally participated in the experiment, and Li Yan directly rejected the ideas.

This situation happened repeatedly, and many times the experimenters had no idea what was going on and were suddenly notified to terminate the experiment because "the idea was wrong."

However, how can we know that our thinking is wrong if there is no result?
Even if the data is not satisfactory ten or a hundred times, we must study and optimize the experimental operation and continue to persevere in the experiment.

Now, the preliminary preparations have just been completed and a group of researchers are still figuring out how to collect data, but suddenly they don’t have to do it anymore.

For example, regarding inhibitors, most people think that this is a very correct idea, and they also admire that Li Yan did not start from an exhaustive approach, but instead provided an ingenious experimental method, directly explored the principles of inhibitory factors, and deduced a large number of possible inhibitor components, thereby greatly improving the experimental efficiency.

Just as everyone was boasting about this and had achieved good results through the experiments, everyone was eager to try and come up with dozens or even hundreds of effective inhibitor factors in one go, but suddenly everything was stopped.

The reason is that "suppression is only used to treat the symptoms, and the existence of multiple general categories is sufficient."

That's not a reason at all.

Yes, Li Yan never explained why he rejected the brilliant ideas he had come up with after much thought.

Do what you are told to do, and don’t do what you are told not to do.

It was so torturous.

What? You ask why people still listen to him even though he's so annoying?

Because other people can't even come up with any ideas.

Just as He Xiaogang said, even if they just studied the ideas that were abandoned by Li Yan every day, it would be enough to give them an epiphany.

This person is completely on another level. It was Li Yan who made gene editing technology an experimental tool. The first effective drug-carrying experiment of nano-symbionts was also carried out by Li Yan. The first successful transformation of CAR-T cells was also completed with the experimental method provided by Li Yan...

How can you not listen to this?
The unhappiness only lasts for a while, but the pleasure is endless.

Unfortunately, the entire blueprint only exists in Li Yan’s mind. Even though many successful experiments have been completed, no one knows whether this universal panacea can be made and how to make it.

Even before the National Day in 2016, when everyone was still discussing whether to go out or stay in the laboratory during the National Day, Li Yan, who was staring at the instrument and drinking coffee, suddenly slammed the table:
"It's done."

(End of this chapter)