Siheyuan: I eat melons while doing scientific research

Chapter 1307 The Leftovers Xiao'e Fancy (5k)

The fact that Gao Zhendong shot and killed the sabotaging agent with a few shots could not be kept secret, and it would not be difficult for the people of Lubyanka to find out about it.

Even some details, such as the people who were clearly not ordinary drivers in the car with him after the incident, were leaked.

After all, the comrades at the No. 3 Rolling Mill felt that this matter was commonplace and did not really realize the intricacies involved. The comrades from the relevant departments were even less likely to make a big show of covering it up. If they did, it would be the best illustration of "protesting too much."

The person in charge wasn't stupid; he immediately realized the problem: "Hmm...it seems you're not so dumb after all. Have you taken any action?"

"Action? We've already lost hard-won local cooperating personnel at this factory, and it's even caused our latest laser eavesdropping technology to become completely ineffective in the south. As for this person himself, we don't have any good solutions."

This is what they call overwhelming force. Whether you think there's a problem or not is unimportant; what matters is whether you can get close enough. In this situation, it's impossible to resort to strange and violent methods, and the unique environment on the southern side also prevents them from making many preparations.

"That……"

"However, we still have other plans; he is not alone."

Upon hearing this, the person in charge nodded. Whether one can do it is one thing, whether one does it or not is another. The former is a matter of ability, the latter is a matter of attitude.

At this point, the polar bear had begun to slide into the unspoken rule of "it doesn't matter if you don't have the ability, you must have the attitude." While it wasn't entirely a bad thing, it was definitely not a good thing either.

"Be careful not to go too far; they are friends, not enemies." The person in charge was still clear-headed.
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Gao Zhendong was unaware that someone had already set their sights on him. At that moment, he was at the Lou family's house, watching Lou Xiao'e's happy face. He had come directly over after work. Lou Xiao'e had finished class or get off work early today and had brought her child to visit her maternal grandparents.

“Zhendong, you don’t know, our Professor Qi is so happy. She keeps urging me to transfer to her major, saying that I was born to do this. It really annoyed our Professor Fan, hahaha.”

Lou Xiao'e's graduate major was thoracic surgery, but she also participated in many antibiotic drug development projects under Professor Qi's supervision. In terms of reputation, she is probably even more prominent in the antibiotic field.

After all, thoracic surgery requires performing one surgery at a time and examining one patient at a time. However, research on antibiotic-resistant bacteria and related drugs is a comprehensive effort; if one study is successful, it can help a large number of patients.

So it's not surprising that Professor Qi looked at Lou Xiao'e with envy. This girl is not only hardworking and capable, but also incredibly lucky.

Although her extraordinary luck manifested itself in a somewhat strange way, as if it were her lover's amazing intuition, the young girl's own intuition was also quite good. She was the first to suggest rifampin as the main drug for treating brucellosis.

However, this "wishful thinking" was naturally met with a "severe crackdown" from Professor Fan. "I'll let you use it for now, but you want to take the whole pot with you? No way!"
Although Lou Xiao'e didn't perform many surgeries, her hands were both steady and nimble. Compared to her classmates, she had a much broader range of medical knowledge and could offer Dr. Fan many good suggestions. In fact, when the cases weren't too difficult, Dr. Fan needed to consult with other departments much less often, which made Dr. Fan very proud.

Give it to you? Dream on.

The verbal sparring between the two big shots was quite an eye-opener for Lou Xiao'e and her junior sister Luo.

"So, your research project on anti-β-lactamase inhibitors has officially concluded?" This is why get out of class ended early; the project was completed, so everyone in the research group could relax a bit.

Lou Xiao'e nodded: "Yes, yes, yes. We could have finished the project a few months earlier, but some experts suggested conducting double-blind trials to complete the entire clinical validation of modern drugs thoroughly. That's why we added these extra months to make up for the double-blind trial."

Gao Zhendong was secretly pleased to hear this. As a complete novice when it came to drugs, he knew nothing about clinical trials, but he had heard of double-blind tests to some extent.

Unexpectedly, once given the opportunity, the comrades working on pharmaceuticals remained steadfast and grounded in their efforts.

"Congratulations on another achievement." Gao Zhendong's words were not an exaggeration. Although he provided some ideas for certain aspects, the actual work was done step by step by Lou Xiao'e and her team.

Lou Xiao'e was a little embarrassed at first, knowing that her achievements were far inferior to Gao Zhendong's, but she quickly cheered up.

It doesn't matter if I don't have as much as Zhendong. As long as I keep making progress, that's enough. If I don't compare myself to Zhendong, my achievements are still worth mentioning.

"Hehe, it's nothing special, nothing compared to you." Lou Xiao'e said modestly, but her curved eyebrows betrayed her smugness.

"So, are we now preparing to officially launch this drug?"

"Yes, but this drug isn't used by everyone; it's not widely available." Even now, in the 21st century, common antibiotics are still the mainstream medications. Drugs like penicillin V potassium and amoxicillin tablets are still important choices for indications, and clavulanate potassium is not added as an anti-β-lactamase inhibitor.

The principle here is similar to not using up all the weapons in an armory at once, but rather upgrading them gradually according to needs.

So when Lou Xiao'e talked about this, she felt a little regretful that the coverage was not wide enough.

Gao Zhendong didn't seem to care; he was already very impressive.

"This shows that this medicine is very high-grade, a premium product. Naturally, it can't be used on every disease. Good things always have a certain level. If the level isn't high enough, we can't get this great medicine you created." Gao Zhendong could easily come up with such comforting words.

"Hehehe, it seems so..." Lou Xiao'e's emotions came and went quickly, and her attention was diverted by Gao Zhendong in no time.

At this point, Lou Xiao'e suddenly realized something was wrong: "Hey, wait a minute, you're trying to steer me away from here again."

Gao Zhendong raised his hand and gave a Gallic salute: "I didn't. Where did I take you?"

Lou Xiao'e said cheerfully, "Do you think there's any drug that can be used as the main weapon? This anti-β-lactamase inhibitor is just an auxiliary one, and it always feels a bit unsatisfactory."

Having followed Gao Zhendong for a long time, Lou Xiao'e's speech also started to sound a bit like Gao Zhendong's, constantly talking about weapons and support. However, this is a common human flaw; people always feel that it's better to be a big fish in a small pond than a small fish in a big pond. No matter how good a support player is, they are not as strong as a main attacker. This is also recorded in games such as League of Legends decades later.

Lou Xiao'e knew that Gao Zhendong had many strange and unusual ideas, so she set her sights on him.

Gao Zhendong chuckled: "Aren't you going to take a break? You really want to switch your allegiance to Professor Qi?"

"No, no, I just want to keep myself occupied. Stop talking nonsense and just tell me if you have anything to do."

Gao Zhendong thought for a moment. He couldn't think of anything else for the time being, since he wasn't in this business. But there was a drug he knew about that he could pick up some scraps of. It would also help Lou Xiao'e pass the time. Besides, Lou Xiao'e knew about this drug and had mentioned it before.

"Well... I don't have any good ideas, but I feel like there's some leftover material we can pick up."

"Scrap material? Is it the kind of antibiotic used for main attacks?" It doesn't matter if it's scrap material or not, this time it has to be an offensive position.

Gao Zhendong thought for a moment: "I guess so. Although it's not used often, when it is, it's used for the main attack, and the name is quite imposing."

"What is it?"

Gao Zhendong laughed and said, "Vancomycin!"

Vancomycin is indeed a powerful name, and given its special uses, it sounds extraordinary.

Lou Xiao'e was deflated upon hearing this: "Vancomycin? There's not even any scrap left, right? We have Vancomycin-23 in China now." Vancomycin isn't just out of stock abroad; even in China, Vancomycin-23 has been isolated and produced using strains from Guizhou. It's not like there's not even any scrap left.

Gao Zhendong laughed and said, "Have you noticed that, according to the literature and records, Vancomycin 23 is more effective than regular vancomycin?"

To be honest, Gao Zhendong didn't expect the Wan-23 project to be completed so soon. According to his memory, it was supposed to have been completed in 68. It seems that the world has changed a lot.

However, he did not show any surprise. Instead, he acted as if he was very familiar with Wan-23. After all, he did nothing but fool Lou Xiao'e.

"Really? I hadn't noticed." Lou Xiao'e had no doubt about Gao Zhendong's nonsense. It was perfectly normal for Zhendong to be familiar with medicine. She still vividly remembered how that "manual" was written back then.

"Really. I suggest you do a thorough analysis and research on Vancomycin-23, and find out why it's more effective than regular vancomycin. Is this considered a leftover ingredient?"

In fact, Vancomycin-23 is indeed vancomycin, but not entirely. It is a branch of vancomycin—norvancomycin, which is more effective. We originally developed it in 68 and started mass production in 69, but it wasn't until 83 that the US government developed this stuff and applied for a patent.

It's not that the US has bad technology and took so long; it's mainly that research on this type of antibiotic depends on obtaining the bacterial strain. The US obtained a similar strain relatively late, and this strain didn't come from within the US, but from its southern neighbor.

This kind of thing shows that the saying "not an inch of land is superfluous" is not just a propaganda slogan, but has real significance.

We were completely unaware of the special nature of this product, and coupled with a lack of awareness about patents, we missed out on obtaining a patent for it, which is a small regret.

Fortunately, this substance has a specific but not very wide range of uses, as it is a very advanced but not broad-spectrum antibiotic, and the dosage is not large. In addition, since it has been used in my country for a long time, according to the relevant regulations and practices of international patents, Citibank's patent for norvancal is not valid in my country, and we can continue to produce and use it freely, so this regret is not too great.

But since Lou Xiao'e is idle anyway, why not let her go and take this thing back? It's something that our country invented first.

If she can realize during the research process that Vancomycin-23 is different from ordinary vancomycin, then the team with experience with Bar-63 (clavulanate potassium) will naturally handle the subsequent patent issues.

Lou Xiao'e's eyes lit up when she heard this. She didn't care about the scraps or anything else; she mainly liked vancomycin, and the name alone made it worth getting her hands on.

"Hmm, this seems interesting. I'll go see Professor Qi later and take a look at the comparison between the domestic and foreign Wan-23. I'll also start this research project while I'm at it." Lou Xiao'e asked Professor Qi for comparative data not because she didn't trust Gao Zhendong, but because she needed a sufficient reason to start this research project.

"If you like it, that's all that matters." Seeing that she had taken the bait, Gao Zhendong wholeheartedly agreed.

"Zhendong, Xiao'e, dinner's ready." The couple were chatting enthusiastically when Lou's mother came over, holding the hands of the two siblings, Yan Zhibuyu and Xiao'e, and invited them to eat.

As the couple walked toward the restaurant, Lou Xiao'e picked up her son and chattered excitedly to Gao Zhendong, who was holding their daughter, about the second piece of good news.

"Oh, right, Zhendong, my school invited me to come back and give a lecture." Lou Xiao'e was practically glowing when she said this.

Gao Zhendong was a little confused for a moment: "Ask you to go back? Aren't you still at your school? You haven't graduated yet."

"I'm talking about the Second Affiliated Hospital of Beijing Medical University, the Second Affiliated Hospital of Beijing Medical University!" Lou Xiao'e pouted.

Oh, I forgot. Lou Xiao'e went to Beijing Second Medical University first, and then Dr. Fan recruited her to study for her master's degree. At the time, Beijing Second Medical University, which did not have a graduate program, was quite distressed.

"Oh, right, right, look at my memory. What did you ask me to say when I went back?" Provide ample emotional support, and proactively ask questions when appropriate.

"I've made some small achievements in drug research, so the Second Affiliated Hospital invited me back to share my experience in drug research and clinical trials with my classmates in the pharmacy department."

Lou Xiao'e's expression at this moment was one of unparalleled confidence.

As one of the few researchers in China who has been a key member in the research of a new drug and has conducted a complete clinical trial under the modern medical system, Lou Xiao'e deserves this invitation.

Now, she can be considered a "renowned scholar" in this field. The Second Affiliated Hospital of Beijing Medical University has a teacher-student relationship with her, so it's perfectly normal for them to invite her back to give a lecture. Without this connection, it's questionable whether they could even get her to give a lecture. It's not that Lou Xiao'e is putting on airs, but she really wouldn't have had the courage to stand on the podium at an unfamiliar school.

At this moment, the two walked and talked until they sat down at the dining table. Lou's father, who had been sitting down for a while, overheard their conversation.

At this moment, Lao Lou was even more excited than Lou Xiao'e and Gao Zhendong themselves.

He moved his lips, a hint of disbelief in his eyes: "Xiao'e, are you telling the truth?"

What a success! What a success! I never imagined that the Lou family could produce someone who could stand on a university lecture platform! It's true that I, Lou, am rich, and it's true that I was once known as "Half-City," but this is something I never dared to dream of before.

It's not easy for a teacher to step onto the university podium, but it's even more difficult to be invited back to give a lecture by one's alma mater before graduation because of one's own achievements. As a worldly old man, Mr. Lou understands this principle very well.

Lou Xiao'e looked at her father with some confusion. "Why are you so excited?" she asked. "Really? The invitation is still in my email. I'm going to focus on preparing for it these next few days."

Mr. and Mrs. Lou exchanged an excited glance: "Good! Good! That's wonderful! Old woman, get ready, I'm going to offer incense and paper money to our ancestors, and present them with delicacies!!"

Lou's mother nodded repeatedly: "Okay! Okay! Okay! Xiao'e, you should prepare well and stay here for a while. Zhendong is busy with work, so we can take care of the child so you can make preparations."

Although there are still aunties from the Lou family helping to look after the children in the courtyard, in order to give the young couple enough time to spend together, the aunties usually come back to the Lou family's place when the couple goes home.

Lou Xiao'e never expected her parents to react so strongly to this matter. She looked at her parents with a silly and innocent expression and nodded blankly, "Mm."

Gao Zhendong was quite happy; this was actually a good thing.

"By the way, Dad, if my eldest brother is free recently, please ask him to come back." Amidst the joyful atmosphere, Gao Zhendong remembered the Children's Day gift package he had in his hand and specifically instructed Lou's father.

"Great!" Mr. Lou felt doubly happy. His son-in-law's special request for his eldest son to come north home was definitely a good thing, and certainly not a small one!
At a radar research institute in Nanjing, two colleagues from the Ministry of Land Resources Research Institute are looking at the testing instruments in front of them with great anticipation.

The comrades from the radar institute explained things to them while preparing for the test.

"This is just a preliminary improvement to the back-end digital signal processing circuit. Because you've just arrived and time is tight, this is all we can do in this rush. Don't worry, this is just a preliminary test to see if our ideas and approaches are correct. If the experiment doesn't meet your expectations, don't worry. The back-end technology isn't very difficult, and the effect that Chief Engineer Gao mentioned can definitely be achieved."

The main reason is that their expectations were a bit high, and this circuit was hastily designed in a very short time after their arrival. Although we were very confident, no one dared to make a 100% guarantee before the results of scientific research were available, for fear that something might go wrong and dampen the enthusiasm of the comrades in the Department of Land Resources.

Since Chief Engineer Gao introduced us, we must do our best to handle things well, and we also need to pay attention to the mental health of our comrades.

However, for them, this back-end signal processing system was not a difficult task. After all, the comrades from the Ministry of Land and Resources had already solved the front-end sensor problem very well, and no matter how complex their back-end was, it was not as complex as the radar back-end developed by the comrades from the Radar Institute.

"Start the test!" The comrades from the radar institute confidently issued the order.

(End of this chapter)