Siheyuan: The prosperous era starting from being a doctor

Chapter 427 Filariasis and the Development of Specific Drugs

morning.

Wang Mengde hurried back to the Institute of Traditional Chinese Medicine.

Originally, Mr. Fan and Professor Wang strongly invited him to have a meal at the Beijing Institute of Microbiology.

In order to entertain him, we even prepared a special meal.

But Wang Mengde has been a bit busy recently, so we can only have this meal there next time.

When he returned to the unit, he was invited over by Vice President Shi.

"Vice President Wang, I asked you to come here today because I need your help with something."

"Mr. Shi, you can just call me Meng De.

If you have anything to ask, just tell me and I will do my best."

Wang Mengde said with a look of panic.

Although Mr. Shi is not as old as his teacher Mr. Pu, he is only in his sixties.

But both his medical skills and qualifications are among the best in the field of traditional Chinese medicine.

In addition, when the Institute of Traditional Chinese Medicine was first established, he was the vice president.

Therefore, his energy is enormous.

Wang Mengde will become the dean in the future, and Mr. Shi’s opinion will be very important and crucial.

On weekdays, the two people don’t communicate much.

But Mr. Shi had a very high opinion of him, and it could be said that he had a special admiration for him, and he praised him more than once in meetings or in front of others.

"Haha, then I will call you Meng De.

Here's the thing. I have a good friend named Nie. He is the director of the Beijing Institute of Parasitic Diseases and is currently researching the treatment and prevention of filariasis.

He called me yesterday and wanted to ask you to come over and give some guidance on their research work."

Mr. Shi said with a smile.

The Beijing Institute of Parasitic Diseases is affiliated to the Chinese Academy of Medical Sciences.

The China Academy of Medical Sciences was established in 56 and is integrated with the Peking Union Medical College. It is an academic center for medical science and a comprehensive medical science research institution.

Like the Chinese Academy of Traditional Chinese Medicine, it is the top scientific research institution in the field of Western medicine.

"Mr. Shi, I have also heard of Mr. Nie. He has been researching the prevention and treatment of filariasis a few years ago and even established a filariasis research laboratory under the Chinese Academy of Medical Sciences.

I heard that some progress was made in the past two years, and a special medicine has been found, and the effect is said to be very good. "

Wang Mengde thought for a moment, then said strangely.

Filariasis.

It is an infectious disease that can cause disability through mosquito bites.

China is one of the countries with the most serious filariasis epidemic.

The epidemic once reached 16 provinces and cities, including North China, South China, Huguang, Yunnan, Guizhou and Sichuan, and more than 800 counties.

There are more than 30 million patients infected with filariasis.

Among them, there are more than five million people suffering from chronic filariasis.

The main symptoms of infected patients are deformities of the limbs and reproductive system, commonly known as "rubber swelling".

It can be said that a tiny insect as thin as a gossamer has caused more than 30 million Chinese people to suffer from poverty and illness.

Before liberation, and in the ten years after liberation.

There is basically no treatment for this disease.

After contracting this disease, you basically have to rely on self-healing. If you can't heal yourself, you can only blame your bad luck.

It was not until 62 that China's famous parasitologist, Mr. Nie, whom Mr. Shi just mentioned, proposed a method to control the source of infection.

The antifilarial drug diethylcarbamazine is used to eliminate microfilariae and adult worms, ultimately achieving the goal of eliminating the source of infection.

“Oh, this is really infuriating to talk about.

You should also know that the drug ethodicarbamazine was successfully developed in the United States.

After Lao Nie discovered in his research a few years ago that this drug was very effective against filariasis, the country began to import it in large quantities.

At first, the United States was very happy. After all, we used real money to buy it, so they were naturally happy to see it. "

After a pause, Mr. Shi sighed and continued:

"In the war in South Vietnam, the troops of the United States suffered heavy casualties from malaria, and their morale was greatly damaged.

Coupled with various other reasons, the war has been in a stalemate.

Later, the United States discovered the real purpose of our import of diethylcarbamazine, and secretly contacted China, hoping that we would export some Qinghaosan. "

"I haven't heard of this, and Qinghaosan and artemisinin have basically never been exported on a large scale. At most, some countries have received a small amount."

Wang Mengde continued.

In China's medical field, there are really not many big things that he doesn't know about.

Especially in matters involving national strategy, superiors would generally consult him for his opinion.

Since he doesn't know, it means that this matter has not been accomplished.

There wasn't even much negotiation.

“This happened three or four years ago, and I also heard about it from Old Nie.

……

In the following years, the country could only import a small amount of ethidium bromide through a third party, but it was just a drop in the bucket.

Old Nie was also ordered to imitate ethodiol and strive to make it domestically, but unfortunately it has not been developed until now. "

Mr. Shi said with some regret.

Filariasis is still rampant in China.

There is an effective medicine, but it is not available for purchase due to some reasons.

Every year, a large number of people are troubled by filariasis, which not only affects their lives but also causes countless losses of life and property.

"Mr. Shi, does Mr. Nie need me to work with him on researching a generic version of the drug diethylcarbamazine?"

Wang Mengde was also in a bad mood.

He had learned about it before, and found out that there was an effective drug for filariasis, so he no longer paid attention to it.

I didn't expect so many things to happen inside.

If he had known this earlier, he would have definitely taken some time to develop a generic version of the drug ethodiola.

For others, developing a drug may be difficult, and even copying it may take a lot of time.

But for him, it's nothing.

Who allowed him to own the space? Through the space, he can look up all the existing Western medicine ingredients in the future.

Even the production process and formula.

"Yes, that's what Lao Nie meant.

He has never dealt with you before, and he knows you've been busy lately, so he asked me to talk to you.

If you are too busy and don’t have time, forget it. But if you are free, I still hope to go to his place first and help him with his research.”

Mr. Shi said with anticipation in his eyes.

Now everyone with a little status and power in the health care system knows about it.

It only took Wang Mengde half a day for Professor Wang from the Beijing Institute of Microbiology to develop an antibiotic drug, which took only two months.

Although the efficacy of this drug has not yet been finalized, the speed of its development has shocked everyone.

At the same time, it also made many people more active.

Since the Beijing Institute of Microbiology can eat meat, they naturally want to get some "meat".

Among them, the most urgent person is Mr. Nie from the China Academy of Medical Sciences.

He originally planned to contact Wang Mengde directly, but was afraid that it would be too presumptuous.

So he asked Mr. Shi to act as a middleman.

"Mr. Shi, I can go there tomorrow. But I have been busy lately, so I will talk to Mr. Nie first to see the situation and then decide how to proceed.

Moreover, Mr. Nie has been conducting research for several years, and his familiarity with filariasis is unmatched in the country.

Therefore, he will be the lead in the later research work. "

Wang Mengde expressed his thoughts.

In fact, he was already multitasking when he was chatting with Mr. Shi just now.

With the help of the space, my mind learned about the composition, chemical formula, production process and formula of ethidium bromide from my previous life.

It can be said.

Now, as long as there are a few students with bachelor's degrees in medicine, they can develop this medicine by following his guidance and spending a little time.

"Haha, Meng De, thank you for giving me this face.

As long as you can go, I don't care what you talk about or how you cooperate with each other."

Mr. Shi said with a happy face.

after.

He has a lot to brag about in front of his old friends.

Now countless eyes are staring at Wang Mengde, and they all want him to go to their own units to guide research work.

Unexpectedly, with his encouragement, the second place they went to was an old friend's.

"Mr. Shi, you are too polite.

So, I will go to see Mr. Nie early tomorrow morning. Please give him a heads up in advance."

Wang Mengde said.

"Okay, Meng De, thank you for your hard work."

After Wang Mengde left, Mr. Shi slowly waved his fist like a child, then picked up the phone and told his old friend the good news.

director's office.

Wang Mengde held the enamel pot and reported two things to President Lu.

One is the development of gentamicin in collaboration with the Beijing Institute of Microbiology.

The second thing is to go to the Beijing Institute of Parasitic Diseases tomorrow to meet with Mr. Nie to discuss the research on ethidium bromide.

"Meng De, since gentamicin has been successfully developed, let Lao Fan and his team conduct clinical trials. You just need to focus on the test data and don't put too much energy into it.

As for Old Nie, if time permits, please go over and help him.

I have also heard of filariasis. Recently, it is said that there are signs of its spread again. If an effective drug can be developed as soon as possible, it will be a great blessing for the country and the people. "

After listening to this, Dean Lu said.

The last time he went to a meeting with his superiors, his superiors also brought up the issue of filariasis during the meeting.

If it weren't for the fact that Wang Mengde was too busy, this task would have fallen on him long ago.

"Well, Dean, I know what to do."

"That's good, you go ahead and get busy.

Remember, you must pay attention to your body. If you feel tired, take a rest in time and don't try to force yourself. "

Dean Lu was worried and gave another instruction.

He is the pillar of Traditional Chinese Medicine and the Chinese Medical Research Institute.

If you get tired, you'll be in big trouble.

the next day.

At the gate of the Beijing Institute of Parasitic Diseases.

Regardless of the cold weather, Mr. Nie wore a thick cotton-padded jacket and stood outside with an excited look on his face, waiting anxiously.

Although the staff of the institute were curious, they did not dare to disturb them.

It was only when he saw Wang Mengde riding a bicycle that a smile from the bottom of his heart appeared on his face.

"Comrade Wang Mengde, thank you for taking the time out of your busy schedule to come and give us your guidance."

Seeing Wang Mengde tied up the bicycle, Mr. Nie hurriedly stepped forward, grabbed the other's hand, shook it vigorously, and then said.

"Mr. Nie, I dare not, I am here to learn from you."

"Hahaha, don't be so modest, we don't care about age, we only consider who has the most achievements first.

It's cold outside, so let's not stand here. Let's go to my office and have a cup of tea to warm ourselves up and taste some of the fine tea leaves I have collected."

As Mr. Nie spoke, he took his hand and walked towards the research institute.

At the same time, he also did a lot of "homework" and knew that Wang Mengde liked to drink tea.

in the office.

Mr. Nie had someone prepare tea sets and boiled water in advance. He took out tea leaves from the cabinet, personally brewed a cup of tea and handed it to Wang Mengde.

Next, the two of them started chatting while drinking tea.

The topic of conversation is definitely about filariasis.

"Comrade Wang Mengde, I have been studying filariasis for more than ten years and know a lot about this worm.

Filariasis is very different from other insect infectious diseases. After the infectious larvae of filarial worms enter the human body, they can only develop into one adult at most and will not reproduce.

The microfilariae only develop in the mosquito's body but cannot reproduce.

This characteristic gives us the opportunity to completely eliminate filariasis, that is, as long as the number of infected people is reduced to a certain level, the spread of filariasis will have no epidemiological significance. "

Mr. Nie introduced his research results in detail.

While listening, Wang Mengde compared it with the knowledge he had learned through space.

He found that Mr. Nie's research was very in-depth and was considered the most authoritative at home and abroad.

"Mr. Nie, among the specific drugs for treating filariasis, is ethodicarbamazine the only one that works best? Are there any other alternative drugs?"

Wang Mengde asked.

He also learned through space that even in later generations, only ethidium bromide was the most effective treatment for filariasis.

But since Mr. Nie has been researching it for such a long time, he still wants to ask more questions. Maybe there are other medicines that can be used as substitutes.

"No, I have tried many drugs, and only diethylcarbamazine works best. All other drugs are not ideal."

Old Nie shook his head.

He has been studying filariasis for more than ten years and has tested countless drugs.

"Then the only way left is to make a generic version of ethodiola."

Wang Mengde nodded.

He had anticipated this situation and was not disappointed.

On the contrary, the generic version of ethidium bromide is the most convenient option for him.

After all, there are ready-made formulas and production processes, so we can just use them directly.

There is no need to think any more.

"Yes, next we can only imitate ethodiola blue, and I asked you to come here to seek your help.

I led a team to try to copy it three years ago, but unfortunately there were no good results. "

Old Nie shook his head, his tone full of regret.

"Mr. Nie, let's do research together. Let me take a look at your research results in the past few years."

Wang Mengde said.

After drinking a cup of tea, the two couldn't wait to come to the laboratory.

First, I learned about the previous research data and results.

It was almost noon when Wang Mengde finally figured it out. He said to Mr. Nie, who looked exhausted:
"Mr. Nie, your research is just one step away from success.

As a bystander, I can see it a little more clearly. You can do this during this experimental step and give it a try. "

(End of this chapter)