A doctor who travels through two eras

Chapter 291 Traditional pharmaceutical manufacturing is difficult to imitate

There are several reasons why crop yields are low:
1. Whether the seeds are high-yielding; 2. Whether the land is fertile or barren; 3. Whether there is enough fertilizer; 4. There should be no water shortage and no flooding.

Too little water is a problem, and too much water is also a problem.

Seeing the groundwater gushing out like crazy and flowing all over the fields, everyone at the Chinese medicine hospital felt extremely distressed.

Only those who have experienced drought know how precious water resources are.

Not to mention other places, just take the Ming Tombs as an example. Even the reservoirs were dry and farmers had difficulty getting water. As a result, the water drawn here was wasted. Everyone felt as if they had lost hundreds of millions.

Vice President Ji gritted his teeth and shouted to everyone:

"Everyone, don't just stand there, hurry up and use tools to dig ditches and divert the water away. Don't let our newly planted crops be drowned."

When everyone heard this, they hurriedly went to look for furniture.

At this moment, a sudden braking sound was heard, and then Dean Shen was seen running over in a hurry.

When Comrade Lao Shen saw the fountain in the middle of the farmland, he was so excited that he burst into laughter:

"Haha, what a good omen! I really picked a good place with good feng shui. The spring water is so good. Oh, why is it all flowing away? Hurry up and catch it."

Sure enough, there was such a severe shortage of water that everyone’s first reaction after seeing water was to keep it.

Lin Sanqi rolled his eyes:

"Dean, are you going to use a basin or a bucket to catch it?"

Dean Shen thought so too. He knew that the groundwater was drilled by Lin Sanqi last night, and Lin Sanqi informed him of the fact over the phone.

"Lao Ji, Xiao Qi, the fact that we have pumped water from our farm must be kept secret. We cannot let the surrounding villages know about it. Otherwise, it will easily lead to land disputes. After all, our farm is theoretically still their village's land."

When the Chinese Medicine Hospital Farm was established, it only had the right to use the land, while the ownership still belonged to several nearby villages.

If they knew that there was a spring on the Chinese Medicine Hospital Farm, there was no doubt that the villagers would want the spring back. If you refused, they would solve the problem the rural way, which was to fight.

Deputy Ji had his own concerns: "Old Shen, I'm afraid this matter can't be kept secret for long?"

"We have to keep it a secret for as long as we can. At least we have to keep our footing. Also, we have to hide this spring so that no one else can see it. Think of a way."

After several hours of gushing, the spring eye is no longer a tall fountain, but a stream of water gushing up like the Baotu Spring.

Baotu Spring?
Lin Sanqi thought of a text he had learned in elementary school, and suddenly he had an inspiration:

"President Shen, Vice President Ji, have you ever seen the real Baotu Spring in Jinan?"

President Shen and Vice President Ji both nodded. For these old comrades who have been involved in the revolution for so many years, they had personally walked through the snow-capped mountains and prairie, let alone Baotu Spring.

"Baotu Spring is a spring that gushes out from underground. Let's learn from Baotu Spring and dig a big pool around the spring. Then people from far away will know that we have built a reservoir, but they won't know that there is something else in the center of the pool."

After hearing what Lin Sanqi said, Dean Shen and Vice Dean Ji immediately had a picture in their minds:

Vice President Ji slapped his thigh:
"Yes, this is a good idea. Nowadays, due to water shortage in rural production and construction, the common method is to build reservoirs. If others can build them, we can build them too, right? It won't attract attention."

Dean Shen also breathed a sigh of relief:

"That's a good idea indeed. Besides, although we can't afford to build a brick wall, we can build a fence around the farm and plant some creepers and gypsophila to at least block the peeping eyes from outside."

Lin Sanqi also nodded repeatedly:

"We must do this. Not only must the spring be kept secret, but our yield per mu will be 2000 catties, while others will only have 100 catties. The disparity in yield will attract people with bad intentions. What if they steal all our produce?"

Some people may say that farmers are simple, so why do you, Lin Sanqi, judge others by your own standards? Why do you think farmers will steal food?

Because Lin Sanqi understands human nature better.

A farmer is almost starving to death, and his entire family, young and old, are skin and bones, but there are large tracts of fruitful corn and wheat fields next to him. What do you think the farmer will do?
If people are starving to death, why would they care about morality and honor? They would definitely steal food to save their lives.

Even if you can't steal, you can just rob. The worst that can happen is that you will die. You will die sooner or later. Chen Sheng and Wu Guang have the most say in this.

When people are in desperate situations, they can do anything. Let alone robbing, even if there is a giant panda in front of you, you will have no problem killing it and eating its meat.

In the words of Professor Luo Xiang, this is called emergency risk avoidance, and there is no legal responsibility.

Dean Shen asked with some doubt:

"Xiao Qi, can you really grow 2000 kilograms of corn per mu with these seeds? Or more than 6000 kilograms of potatoes per mu? Are you bragging?"

In the 5,000-year history of this land, there has never been a period or region where the crop yield has reached such an astonishing figure. No wonder Dean Shen was a little bit unconvinced.

Lin Sanqi explained with a smile:
"Uncle Shen, do you usually not read books or newspapers? The newspaper said that the grain yield per mu in Liuzhou has reached 100,000 kilograms, and a child can sit on rice without falling. Is our yield per mu more than 1,000 kilograms?"

Dean Shen's face suddenly turned from red to white, from white to blue, and then from blue to black. He suddenly yelled at Lin Sanqi:
"Bullshit, bullshit, you are all from the mud, don't you know how much the yield per mu is? You said it's 100,000 kilograms per mu, weigh all the soil in the field, is it 100,000 kilograms? You are a bunch of beasts."

Lin Sanqi was sprayed with spit by the old man and quickly wiped it off:
"Anyway, I can guarantee the yield of 1000 kilograms of corn, 800 kilograms of wheat, and 3000 kilograms of potatoes per acre, and it will only be more, not less. If there is less, I will make up for the shortfall."

Vice President Ji didn't care what Dean Shen was doing and started to settle the accounts excitedly.

"If the yield per mu is really over 1,000 kilograms, then our 1,000 mu of land will make us rich, and the thousands of employees and their families at our Chinese medicine hospital will all be able to eat."

Lin Sanqi added: "I'm just too full. I can exchange it for meat."

Hehehe~~~
Lin Sanqi and Vice President Ji chuckled at the thought of a bright future. President Shen obviously hadn't recovered yet and sighed:

"We have preferential policies from the state. No matter how much the farm produces, we can keep it for ourselves and don't have to pay the public grain tax. But other places have to pay the public grain tax. The higher the yield per mu, the more you have to pay. Those who brag about it deserve to die."

Vice President Ji quickly reminded him, "Alright, alright, Old Shen, stop talking. If you continue, this novel will be sent to the palace again."

Lin Sanqi also quickly changed the subject:

"So we need to dig a hole. How do we do it? By hand or by machine?"

Vice President Ji said without hesitation: "I will organize some people right away. If we all work together and work hard for half a month, we will definitely be able to dig a big pond."

Lin Sanqi thought to himself, you let the weak scholars dig a pond, and then they have to carry the mud and rocks away on their shoulders, how much time and energy will that take?

Moreover, he can still use this group of medical staff. After waiting for so long, the four secret medicines contributed by those old national treasures should be produced by now, right?

Dean Shen looked at Lin Sanqi suspiciously:
"You must have some idea, kid? Can you get some mechanized tools?"

Lin Sanqi smiled and said, "Don't worry, leave it to me..."

At that time, there were also excavators, bulldozers and other mechanized equipment in the country, but they were very few. There was no Lanxiang in those days, and all the machinery was in the hands of the engineering corps.

Lin Sanqi returned to modern society and bought a second-hand excavator.

After years of being exposed to wind and rain, and with the construction site filled with sewage and mud, the second-hand excavator looked riddled and dilapidated, and was not at all eye-catching.

After learning the operation for one day, Lin Sanqi started working on the computer with full confidence.

Fortunately, the structures of excavators in the 1950s and 1960s were similar to those of excavators decades later and would not arouse suspicion, so Lin Sanqi started working during the day.

With the spring as the center, a pond of three acres square was dug, which will not only be used for irrigation but also for raising fish.

The excavated soil was transported to the edge of the farm by large trucks, and an earthen Great Wall was built starting from the foot of the mountain.

Lin Sanqi drove the excavator again and dug a 3-meter-deep and 5-meter-wide trench on the edge of the farm, like a moat around the city, to prevent villagers from entering and leaving the farm at will.

Director Shen also selected 20 young and strong people from among the employees' families to serve as temporary security guards, whose duty is to protect the safety of the farm.

While Lin Sanqi was busy, the Chinese medicine hospital was less busy because the flu epidemic was over, so they began to develop the four medicines that Lin Sanqi needed: "Qingxin Zhengfeng Pills", "Babao Pills", "Duanxueliu" and "Aoaojiao".

In the pharmacy

Lin Sanqi, who was covered in ashes, left the construction site, looked at the pills in front of him, and asked in surprise:
"Master, is this your Qingxin Zhengfeng Pill?"

Xiao Longyou raised his chin high and said, "My family's Qingfeng Pills are handed down from ancestors. Remember, my Qingfeng Pills are much more authentic than the Le family's Angong Niuhuang Pills."

Lin Sanqi nodded repeatedly and asked doubtfully:

"Master, why did the Le family name it Angong Pills? People who don't know would think it's a pregnancy-stabilizing medicine." "You should really learn it. Angong means to calm the "heart palace". The heart governs the mind, and any symptoms such as high fever, coma, irritability and incoherent speech are considered to be a sign of "heart" being disturbed.

Therefore, when the warm and hot evil invades the heart, the pericardium will be affected by the evil on behalf of the heart, which is called heat entering the pericardium. Angong Pills are mainly based on Niuhuang to clear the heart and detoxify, and penetrate the pericardium. They are combined into pills to clear the heat evil that has invaded the pericardium, thereby clearing the heat evil.

The mind can settle in its palace, so it should be named Anxin Niuhuang Pills, but our family’s pills are called “Qingxin Zhengfeng Pills”, which takes the word “heart”, so theirs can only be called Angong Niuhuang Pills. ”

Lin Sanqi and Pan Ye were filled with curiosity as they looked at the pill in front of them, which was the same size and color as a "maltose pill".

Lin Sanqi picked up the pill and smelled it, then asked curiously:

"Master, the Le family's Angong Niuhuang Pills have become a national secret prescription and are not known to outsiders. Which part do you think needs to be kept secret? After all, the medicinal materials used in Angong Niuhuang Pills are public, so how can they be kept secret?"

Mr. Xiao asked back: "Oh, then tell me, what medicinal materials are used in their Angong Niuhuang Pills?"

Lin Sanqi had read the materials and could actually recite this:

"Let me calculate. It should be composed of 11 medicinal ingredients: bezoar, musk, buffalo horn, coptis root, scutellaria, gardenia, cinnabar, pearl, realgar, curcuma, and borneol."

"and many more!"

Old Master Xiao frowned, "That's not right. Tong Ren Tang uses buffalo horns? They don't use rhino horns anymore?"

Lin Sanqi stuck out his tongue, knowing that he had let the cat out of the bag. Since the animal protection law had not yet been issued, it was completely possible to use rhino horns.

"No, I remembered it wrong. By the way, Master, I don't understand one thing. Since the ingredients of the formula are already known to outsiders, why do they still claim that it is a confidential formula?"

Xiao Longyou sighed, thinking that Lin Sanqi was a hopeless child, but since he was his own disciple, he could only explain patiently:

"Whether it's Angong Niuhuang Pills or my Qingxin Zhengfeng Pills, they come from the same school and are both traditional raw powder pills, which means all the medicinal materials are ground into fine powder, and then the powder is mixed with refined honey to make pills directly without going through the extraction process.

It doesn’t look complicated on the surface. It just consists of five steps: powder making, mixing, pill making, coating, and wax sealing. You should think so, right? "

Lin Sanqi nodded repeatedly, thinking to himself, to put it bluntly, isn't it just mixing all the herbs together and kneading them into balls? How simple is that?
But since the old man asked this, he must have his intention, so Lin Sanqi quickly took out a pen and paper, knowing that the sex scene was about to begin and he had to record it down quickly.

Old Master Xiao was very satisfied with Lin Sanqi's good memory but poor writing skills. He was a good student who learned even when he didn't understand.

“However, there is a mystery hidden in the five steps I just mentioned.

How finely should the herbs be ground? How should they be ground? How should they be mixed gradually without losing any ingredients? How old should the honey be and how much honey should be added? How should the honey be mixed and gradually soaked?
What different measures should be taken in different seasons? How can we make honey pills melt in our mouths without leaving any residue? How can we beat gold into a thin and fragile golden coating?

How to make sealed wax pills? What is the thickness of the wax seal? How to make the wax shell not only have good sealing properties, but also be beautiful and easy to engrave, etc. These are the secrets to ensure the efficacy of the pills. "

Lin Sanqi put down his notebook, his head was dizzy:

"Master, so many questions? So complicated? My God, it's really hard for ordinary people to learn it."

"It's hard to learn, and it's even harder to do."

Old Master Xiao took out a white plate from the side, and a strong smell immediately spread around.

"Look, this is musk (natural wild). Musk is taken from the musk sac at the navel of the forest musk deer, the horse musk deer or the original musk deer. Therefore, the musk kernels are mixed with a lot of fluff. You see, it is densely packed with fluff all over.

Since musk kernels are soft and oily, in order not to affect the pills and taste, these hairs must be picked out manually. Look again, this dish of musk is clean and pure musk, which can be used as medicine. Compare it. "

Lin Sanqi compared them and asked in surprise:

"Wow, the fluff is so fine and small. How long will it take to pick it out?"

Song Xingjian, a Chinese medicine practitioner standing nearby, smiled and replied:
"I did this job when I was an apprentice. After picking the hair seven or eight times, I felt very satisfied and handed it to the master for inspection. The master said it was too early and the work was too careless. I felt wronged at the time.

Later, the master took the tool from my hand and continued to pick the hairs from the musk over and over again, demonstrating to me. "Doctor Kobayashi, don't underestimate this dish of musk. It takes three days and three nights to pick the hairs."

"Wow~~~This is very labor-intensive."

Lin Sanqi thought, no wonder all the major Chinese medicine factories gave up handmade production after a few decades. One reason is that natural raw materials cannot be used or are too rare. Another reason is that the labor and efficiency are really not affordable. "

"Then Master, if we release this Qingfeng Zhengxin Pill, we must keep it as a secret formula, so that it cannot be easily reversed and imitated by outsiders. Do we have any means to prevent others from imitating us?"

Angong Niuhuang Wan is not a "trade name" but a "generic name". There are hundreds of pharmaceutical companies across the country that produce Angong Niuhuang Wan and sell it on the market.

But among hundreds of pharmaceutical companies, only Tongrentang is the most famous, which shows that Tongrentang Pharmaceutical must have its unique features to stand out.

Mr. Xiao is almost 80 years old. His energy is not as good as before, so he pointed at Song Xingjian next to him and said:

"Xiao Song is an honest man who keeps his mouth shut. I gave him the production process of Qingxin Zhengfeng Pills and the proportion of the main and auxiliary drugs in the prescription. Let him teach you."

Song Xingjian is already over 50 years old this year. He has been a pharmacist since he was a child and has worked in a pharmacy for nearly 40 years. He can be called a half-grandmaster.

"Master Song, thank you for your help."

"Hey, Doctor Xiaolin, you're too polite. Don't worry, our pharmacy has its own rules. I will keep the production process that the old men gave me to myself and will not spread it around."

Lin Sanqi nodded, knowing that the older generation of intellectuals had dignity, abided by the rules of the trade, kept their promises, and could be trusted.

"Master Song, what is so special about my master's Qingxin Zhengfeng Pills? If I want to sell it to someone else to do the production, how can I keep it a secret?"

Master Song nodded, took out a tool and started practicing:
"Qingxin Zhengfeng Pills, the manufacturing process is indeed different from other Angong Pills, such as the 'water flying method', 'circling for 100 days', and 'beating 100 hammers'. These three methods are rarely used pharmaceutical processes. Doctor Kobayashi, please listen to my explanation.

For example, cinnabar and realgar are insoluble in water, which will affect the performance of the medicine and thus affect the efficacy. We need to crush the medicine appropriately, grind it into a paste with an appropriate amount of water, and stir it with a large amount of water.

Wait for a while, wait for the coarse powder to settle, then pour out the suspension. Grind the settled coarse particles again, repeat the process until the mixture is fine. Finally, combine the poured suspension, dry the precipitate, and grind it into a fine powder.

This method of preparing ultra-fine powder by repeated grinding and separation using the different suspension properties of coarse and fine powders in water is the "water flying method" recorded in the Song Dynasty's "Shenghui Fang". This process is rarely used now because it is too complicated. "

Lin Sanqi understood, and then he combined it with the Western medicine knowledge he had learned and quickly understood it.

The ultimate purpose of using the raw powder of cinnabar and realgar as medicine is to increase the surface area of ​​the drug, promote its dissolution and absorption, and improve its bioavailability.

For this reason alone, the finer the crush, the better, and the more and faster it will be absorbed.

Therefore, there is a concept of "ultrafine grinding" in modern pharmaceutical technology.

即粒径在1~100nm称纳米粉体,粒径在0.1~1um称为亚微米粉体,粒径在大于1μm称微米粉体;一般说来粒径在5μm以下,即可达到提高疗效的目的。

The pharmaceutical processes of Chinese and Western medicine are different, but the methods are similar, which means that the results are also the same.

Song Xingjian continued to introduce:

“There are other medicinal ingredients, and we all need different processes to make them. For example, for pearls, we have to cut the tofu, dig out the core, wrap the pearls in gauze, put them in the tofu, cover them, steam them in a steamer for the appropriate time, and make them into powder through special processing;

In addition, Coptis chinensis, Scutellaria baicalensis, Gardenia jasminoides, Curcuma aromatica powder, Borneol, Bezoar, Rhinoceros horn and Musk all have their own special processing methods. After grinding into powder, the above-mentioned powders must be ground in equal amounts according to the color method, mixed evenly and sieved.

This is the special method of making powder, and this is the method of incremental coloration. I have recorded it all according to Mr. Xiao's dictation. "

When Lin Sanqi took over the information, his mind was a little confused. He thought that there were so many requirements for grinding alone. This ancient method of making medicine was too difficult to learn and too hard to handle.

"Next, we will start to refine the old honey. We will mix the honey at the appropriate temperature with the medicinal powder to make a medicine ball, put it into a porcelain container and seal it. This is called 'circle for 100 days'. This will allow the medicine ball to be evenly moisturized...

After 100 days, the pills are taken out and beaten with a jujube wood hammer, which is called "beating a hundred hammers". Then they are placed on a pill-pushing board and pushed into pills of the same size. Finally, they are wrapped in gold, waxed, and packaged. The Qingxin Zhengfeng Pills are then completed."

This lecture lasted for nearly two hours. Lin Sanqi already had a thick stack of materials in his hand, and he was so confused after listening to it.

Xiao Youlong looked at Lin Sanqi with a half-smile: "How is it, do you understand?"

Lin Sanqi scratched his head: "Maybe, maybe, I understood some of it."

Pan Ye said firmly beside him: "Master, don't worry, I understand everything and I have remembered the precautions."

Old Master Xiao smiled with relief: "It's not bad, Xiaolin, you found a good wife."

Pan Ye blushed again when he heard this, but Lin Sanqi was a little smug: "That's right, your disciple has such good taste."

Master Song also said happily:

"So, Doctor Kobayashi, are you still afraid that others will imitate our pharmaceutical process? It's not difficult for outsiders to reversely analyze which medicinal ingredients are used, but the difficulty lies in the production process. Qingfeng Pills have more than a hundred steps, and others can't imitate it.

Even Tong Ren Tang's Angong Niuhuang Pills, their production process is very different from our Qingfeng Pills, so in terms of efficacy, their Angong Pills cannot compare to our Qingfeng Pills. After clinical use, we will know which one has better efficacy. " (End of this chapter)

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