Traveling through the sword to engage in military industry.

Chapter 501 Side Breakthrough
After basically getting a handle on the aviation industry, Ren Zhong turned his attention to the pharmaceutical industry.

In the world of Liang Jian, Dongda Pharmaceutical Industry, which started with penicillin, is not weak. Under the care of Ren Zhong, it has firmly controlled the patent technology licensing of penicillin and its derivatives, making this drug for treating various bacterial infections the best-selling pharmaceutical product in the world of Liang Jian.

The huge output from direct sales and the high patent fees for authorization have made Dongda Pharmaceutical one of the top ten pharmaceutical companies in the world with this product.

However, Ren Zhong did not stop the pharmaceutical industry of Dongda University. After penicillin, he obtained the manufacturing process information of another important drug, adenosine, from the main world. He handed this information to the Medical Research Center and asked them to research and replicate the complete and detailed production process of this broad-spectrum antiviral drug in the world of Bright Sword based on this information.

Although there are many methods for preparing this medicine in the main world, such as the two most classic production methods:
Method 5: 5'-adenine nucleotide (8'-AMP) is used as a raw material, and selective p-toluenesulfonylation, hydrolysis dephosphorylation, bromination, and acetylation are performed to obtain 3-hydroxy-N, 5', 2'-O-triethyl-8'-O-p-toluenesulfonyl adenosine, which is then cyclized in methanol-ammonia, and then ring-opened in methanol-hydrogen sulfide to obtain -mercaptoarabinoadenosine, which is then desulfurized by hydrogenation to obtain adenosine.

5'-腺嘌呤核苷酸[对甲苯磺酰氯]→2'-O-对甲苯磺酰基腺苷-5’-单磷酸酯[氨水，甲酰胺]→2’-O-对甲苯磺酰基腺苷酸[Br2]→8-溴-2’-O-对甲苯磺酰基腺苷[乙酸，醋酐]→8-羟基-N， 3'， 5'-O-三乙基-2'-O-对甲苯磺酰基腺苷[甲醇氨]→8， 2'-O-环化腺苷[甲醇-硫化氢]→8-巯基阿糖腺苷[兰尼镍]→阿糖腺苷

Method 9: Using uridine as a raw material, it first reacts with phosphorus oxychloride and dimethylformamide, and then hydrolyzes under alkaline conditions (pH=60) to obtain uridine arabinoside, which is then hydrolyzed by pyrimidine nucleoside phosphorylase at a temperature of 1°C to remove uracil to obtain arabinose-60-phosphate, which is then condensed with adenine at °C to obtain adenosine arabinoside by purine nucleoside phosphorylase.

Uridine [phosphorus oxychloride, dimethylformamide] → [pH 9] uridine arabinoside [pyrimidine nucleoside phosphorylase] → arabinose-1-phosphate [purine nucleoside phosphorylase] → adenosine.

Even though Ren Zhong tried his best to collect relevant information from the main world, these were still mainly principle-level methods, and he had not found the various process standards from the preparation of process equipment to intermediate mass production. It can only be said that the technical route direction is correct, but it is far from enough for mass production.

Therefore, based on the preparation process information provided by Ren Zhong, the Medical Research Center had to do both process design and mass production research. Although this reduced the time cost of countless trial-and-error technical branches, in order to reach the level of practical process production, the Medical Research Center spent four or five years working overtime to complete the preliminary preparation process methods and began to achieve small-batch production. Then, after 3/4 years of clinical trials, it finally completed various clinical effect verifications in 1959 and entered the mass production scale application stage.

Yandu, Office of the Director of Liming Research Institute.

"Dean Ren, our new drug has now completed clinical trials at Southeast University and is ready for mass production. Now we need to give it a name. Comrades all say that this was completed based on the idea provided by Dean Ren, and it is appropriate for Dean Ren to name it." Professor Mu Senlin, head of the Medical Research Center, handed the report to Ren Zhong very respectfully.

Ren Zhong took the report and briefly looked at the conclusion part. After clinical trials, this drug has been shown to be effective in treating viral diseases such as chronic hepatitis B, herpes simplex encephalitis, herpes zoster, genital herpes, neonatal herpes simplex infection, chickenpox in immunocompromised patients, herpetic myelitis, keratitis and keratoconjunctivitis, cytomegalovirus pneumonia, as well as diseases such as angina pectoris, myocardial infarction, coronary insufficiency, arteriosclerosis, primary hypertension, cerebrovascular disorders, sequelae of stroke, and progressive muscular atrophy.

These are all the treatable diseases provided by Ren Zhong, so naturally they all need to undergo clinical trials one by one. Fortunately, Ren Zhong also provided a short list of diseases, which made the research work more targeted and the clinical trials could be completed in just a few years.

"Yes, Professor Mu, your work is very effective. With the launch of this drug, we will have another trump card in the pharmaceutical field of Dongda University." Ren Zhong said to Professor Mu Senlin after reading the report. "As for the name of the drug,"

Ren Zhong thought for a while before looking up and saying, "Since the main function of our drug is antiviral, I think we should call it virus-clearing injection as the name suggests. As for the English name, I think it should be called broad-spectrum antiviral injection, which is also worthy of the name."

This drug is poorly absorbed by oral, intramuscular or subcutaneous injection, and is best administered by intravenous drip, so injections are the main form of medication.

"Good names, Virus Clear and Broad-spectrum Antiviral Injection are both good names!" Professor Mu responded with praise. "Then we will use these two names for registration."

These were all small matters. The following series of work, such as registering trademarks and applying for patents for confidential processes, were all handled very quickly and on a special basis. During this period, the production line of Dongda Pharmaceutical was also completed. After the intellectual property issues were in place, the first batch of mass-produced drugs began to be supplied to Dongda's domestic hospitals and began large-scale clinical applications.

For the vast number of patients suffering from viral infections, the advent of Virus Clear has greatly alleviated the patients' pain. Many patients quickly achieved therapeutic effects after using this drug. After just half a year of large-scale clinical application, the overall efficacy of this drug has once again shocked the world medical community!
After a short period of clinical trials and information exchange, Europe approved the drug very quickly. Now, relying on the good relationship between Dongda and John Bull, and Dongda's long-term operations in other European countries, Dongda's drugs can also enjoy special channels to pass Europe's drug inspection standards and begin to obtain the right to be sold in Europe.

As a result, broad-spectrum antiviral injection pharmaceutical products soon became another cash cow for Dongda Pharmaceutical!

However, at this time, discordant voices came out again.

In the process of applying for North American FDA certification, the certification time was too slow because FDA certification was as slow as ever and due to the influence of certain pharmaceutical giants.

Even though the Situ family was pushing this matter strongly behind the scenes, in this regard, a group company under the Situ family, as the North American general agent, acted as a professional promoter and mobilized a lot of influence but failed to overwhelm the local pharmaceutical giants.

When the issue of this drug's launch in the North American market was reported to higher levels, it finally came to Ren Zhong's desk.

"We're taking a different approach this time. If the FDA officials want to drag their feet, we'll just wait for them! But in terms of the drug's effectiveness, we need to find ways to inform North American patients that we now have such a drug. I think we can increase publicity and news coverage of this drug in medical publications and television media science programs." Ren Zhong instructed the team handling this matter.

Although the team was somewhat surprised by Ren Zhong's reaction this time, they still faithfully implemented this opinion.

They don’t know that in terms of broad-spectrum antiviral drugs, there is no better drug in this time and space than this one from Dongda. Just like penicillin, the efficacy of this drug is unique!
Ren Zhong is waiting for the North American patients to understand the efficacy of the drug. Ren Zhong does not believe that they can sit still!

This time, Ren Zhong is not going to let Dongda officially bargain with the other party to reach a compromise, but is going to use North American patients to deal with the FDA. Houston.

"Mark, little Willy's shingles infection has lasted for several weeks and hasn't gotten better. It's really worrying." A young mother looked at her 5-year-old son with a face full of worry.

Mark, who was next to her, was reading a newspaper, when suddenly he saw shocking news.

"Viral diseases have been conquered and broad-spectrum antiviral injections have been developed." Below this scientific news is a comparison of the effects of multiple groups of different drug treatments for more than ten viral diseases from Europe. According to the above data, a broad-spectrum antiviral injection from Dongda University is several times more effective than traditional treatments, and is almost a specific medicine for viral diseases!
"Mary, don't worry. There is a specific medicine for little Willy's illness. Tomorrow we will ask the doctor where we can buy this broad-spectrum antiviral injection. If we use this specific medicine, little Willy will be cured in a few days."

Mark handed the newspaper to his wife Mary as he spoke. He pointed to the comparison of the efficacy of the disease and said, "Look, the cure rate for herpes zoster is over 95%. My God, this broad-spectrum antiviral injection is amazing."

Manhattan.

Nick, who lives in a bachelor apartment, is a little fed up with his own unspeakable secret.

As an open-minded and normal-oriented man, he is more or less unable to control his little head in the midst of the bright lights and wine, and it is inevitable that he will be infected by the women if he wanders around too much. For example, the private herpes he got three months ago has tormented him for so long and there is no improvement. The damn doctor just told him to keep himself clean to avoid this disease, but he never thought about how to cure it.

He turned on the Star TV with a feeling of despair, and happened to see a news report about the treatment of herpes in the European Hospital. It said that since the advent of broad-spectrum antiviral injections, the cure rate of herpes in the European hospital has reached over 95%. With broad-spectrum antiviral injections, all kinds of herpes are no longer a problem!

"Shit, damn doctor, you have such good medicine but you don't want to use it on me. Is my health insurance only for the rich?" Nick couldn't stand it anymore and cursed at the TV. He secretly decided that he would ask the doctor to prescribe such a special medicine to treat his illness tomorrow.

However, when these patients rushed into the hospital excitedly and asked to use this latest miracle drug to treat themselves.

Every doctor told them with great regret, "Yes, we have noticed this special antiviral drug, but I am very sorry that the FDA has not yet approved this special drug, so it cannot be imported. It is currently only sold in countries and regions such as Europe and Southeast Asia."

Coming with high hopes and leaving disappointed, this gap should not be too big for patients who come with high hopes.

However, they had no control over these things. Those who were almost helpless due to the torture of the disease tried every means to go to Europe for treatment and be the first to use this special medicine.

After thousands of smart patients verified the effectiveness of this special medicine through their medical treatment journeys, they passed this information back to hundreds of thousands or even millions of similar patients in North America. These people, either due to economic factors or other reasons, could not travel across the ocean to use this special medicine for treatment. Some gray gangs saw this opportunity and began to find ways to purchase some from Europe and secretly bring it into North America, and give it to the poor North American patients at 3 to 5 times the price.

As time went by, everyone realized that something was wrong. After curing thousands of patients among the public, this special medicine had not yet passed the FDA's certification process, making it impossible for this special medicine to be officially introduced into North America.

Some curious reporters discovered this problem and began to investigate secretly. The result made them extremely angry. The FDA was simply perfunctory in the certification work of this special medicine. They did not carry out the certification of this special medicine according to normal procedures, but repeatedly asked the other party to provide various information!
In terms of process, this means that the certification of this drug will be delayed indefinitely.

When reporters exposed this news through newspapers and television media, people's anger was immediately ignited!

At first, only some patients and their families began to denounce the FDA's misconduct in newspapers and television interviews. Then patients like Nick began to take to the streets, holding banners and shouting loudly!

Soon, more and more patients learned about this matter, and they began to take to the streets to support Nick's call. From a few hundred people, to a few thousand people, in a few cities, it slowly developed into a joint petition campaign of tens of thousands of people in dozens of cities. This kind of pressure, like a tsunami, directly scared the people working in the FDA!
They had not imagined that taking a little benefit from the pharmaceutical giant to carry out certification of a pharmaceutical company as per the usual practice would turn into such a large-scale mass incident.

It's like stirring up a hornet's nest, turning the FDA into a rat crossing the street that everyone wants to beat. Now even when it goes out, it will be pelted with rotten eggs and tomatoes.

Now they didn't dare to make trouble anymore and started to make an urgent meeting with Dongda Pharmaceutical to start the formal process. However, at this time, Dongda Pharmaceutical, which was watching the fire from the other side of the river, was not panicked.

They calmly enjoyed the special treatment of being escorted through the certification process at their own pace. Only a very small number of senior executives of Dongda Pharmaceutical knew about this matter, and there were reasons why the news was exposed in many media.

This was the first time that Ren Zhong used the media seeds he had planted to serve Southeast University.

Judging from the results, the effect is much better than formal government negotiations.

(End of this chapter)