After being fired, I became the light of medicine

Chapter 245 Shocking Subjects!
Department of Hematology, in the ward.

Since all the more than 30 subjects who participated in the "ibactuzumab" monotherapy were critically ill patients and their lives were in danger at any time, they were all hospitalized for treatment after participating in the clinical trial.

On the one hand, it can maximize the guarantee of the life safety of these critically ill patients during clinical trials and avoid disputes.

On the other hand, it will also make it easier for Tsingshan Pharmaceutical to collect clinical data of subjects in a detailed and accurate manner.

At the same time, in order to facilitate management, Director Hu also specially set aside ten wards to accommodate subjects who take medication independently.

In the ward.

The ward, which originally had four people, was now crammed with nearly thirty subjects.

Director Hu and Wei Tian were surrounded in the middle, wearing masks.

"This is Mr. Wei, the person in charge of the research and development of our targeted drug 'Ibetumumab' at Qingshan Pharmaceutical. I think everyone knows him."

"Well, Director Hu, we know this CEO."

"Yes, I know him too. The last person who signed the consent form was the one recorded in the video by this boss!"

"That's good."

Director Hu briefly introduced Wei Tian, ​​and it was obvious that everyone had a deep impression of Wei Tian.

Then he paused:

"Since we all know each other, I'll get straight to the point."

"Everyone has received two injections of the targeted drug 'ibuzumab', and everyone knows the effect of this two-week treatment."

"The good news is that the targeted drug 'ibukumab' is indeed effective. We have a total of 32 independent drug use quotas, and the leukemia cancer cells in all 32 subjects have been significantly reduced."

“But the bad news is… for some patients, the treatment is very effective, and the leukemia cells in their bodies are reduced by nearly 90% in just two weeks;
For some patients, after two weeks, there are still many leukemia cells in their bodies, and the clearance rate is low, with the remaining leukemia cells close to 50%. "

"It's clear that the effectiveness of Ibamipanib varies greatly between different patients!"

After the words were spoken, everyone nodded.

In fact, everyone has already known about this situation through private communications over the past two weeks.

Those patients who had poor treatment effects as mentioned by Director Hu could not help but reveal unspeakable pain on their faces when they heard this. They all used the same medicine and the same treatment methods, but others had good effects while they did not. Is this their fate?
Director Hu saw everyone's expressions. He coughed lightly and continued:
"So, based on this, it can be confirmed that the therapeutic effect of 'ibukumab' is still unstable!"

"Qingshan Pharmaceutical, that is, Mr. Wei next to me, they hope to stabilize the therapeutic effect of 'Ibetumumab' and increase it to a stable 80-90% therapeutic effect. Is it even possible to achieve a cure in the end?"

cure?!
This time, even those patients who had a 70-80% treatment effect and looked quite calm were moved.

Although their current treatment results are very good, who doesn’t want to eliminate more leukemia cancer cells in the body?
Even, cured!

After just a few words, the crowded ward instantly became silent. Everyone looked at Director Hu, looking forward to his next topic!
"So, this requires everyone's help and cooperation!"

As he spoke, he looked at Wei Tian:
"Qingshan Pharmaceutical's next improvement plan is to prepare to extract more and more comprehensive biological tissue and blood samples from your bodies for more detailed analysis."

"The frequency of blood draws has been changed from once every three days to once every six hours. At least four blood draws are required a day to achieve more detailed monitoring every six hours."

“This process is currently tentatively scheduled to take seven days.”

Pause again:
"In addition, two bone marrow punctures and two bone marrow samples will be required in the next week..."

"At the same time, all feces and urine must be stored according to regulations, and the whole process is somewhat cumbersome."

The crowded ward became even quieter, even the sound of breathing seemed to be much quieter.

Especially when they heard about a bone marrow puncture to extract a bone marrow sample, everyone's face changed slightly as they remembered the pain of the bone marrow puncture.

Wei Tian, ​​who had been silent, also felt the atmosphere in the ward become solemn. He coughed lightly and stood up, saying:
"Dear patients, I am one of the people responsible for the research and development of the drug 'Ibetumumab' at Qingshan Pharmaceutical."

"Our 'ibukumab' has currently achieved a 90% killing effect on leukemia cells in some patients, which proves that our drug ingredients are correct and our target is close to being correct."

“But now there are obvious differences between patients, so we need to find the reasons for the differences;

We need to analyze what happens in the bodies of patients with 90% treatment effect and 50% treatment effect, what are the differences between them after taking the medicine, and what went wrong! "

"Of course, this does not mean that we only need to analyze patients who have achieved 90% treatment effect and patients who have achieved 50% treatment effect. Instead, we need to analyze the data of all patients who have achieved treatment effect!"

"Because only when we have enough data samples can we find the reasons for the differences!"

“So, I hope everyone will try to participate in this improvement plan regardless of whether the treatment effect is good or bad!”

As he spoke, Wei Tian couldn't help but take a deep breath and confessed:

"Of course, this process will be painful and may even have some impact on your body, but I can guarantee that we will do our best to ensure everyone's health!"

"Of course, we also adopt the voluntary principle for this improvement plan. Even if you have concerns and don't want to participate, we will not force you."

After he finished speaking, more than thirty people in the ward fell silent.

To be honest, Wei Tian’s explanation was easy to understand, and even patients who had no experience in drug development could understand it all at once.

Everyone knew that Qingshan Pharmaceutical's goal was to find differentiation and develop better therapeutic drugs for all leukemia patients. However, when they thought of the pain of bone marrow puncture and the harm that two bone marrow punctures within a week would cause to the human body, everyone hesitated.

The hesitation in everyone's eyes fell into Wei Tian's eyes. He could understand the worries and hesitations of all patients.

Again, patients who can participate in the treatment of "ibactuzumab" alone are all seriously critically ill patients, and they no longer have the capital to struggle any further!

He sighed slightly in his heart, and then said:
"Dear patients, I have explained the specific situation and reasons to you clearly."

"Well, everyone can consider it. If you are willing to participate in the improvement plan, please contact Director Hu..."

"Don't think about it, I do!"

As soon as Wei Tian's slightly disappointed voice fell, a firm and crisp voice suddenly rang out!

Wei Tian's whole body shuddered suddenly, and he looked in the direction of the voice. A young patient raised his right hand high, which was particularly dazzling among the crowded group of patients!
He vaguely remembered the patient's name - Liu Xiaochuan, 24 years old, just graduated from Sichuan University.

"Boss Wei, I am willing. I have nothing else to consider!"

"Although the effect of my first shot reached about 73%, logically I don't need to be so anxious, but!"

"If it weren't for Qingshan Pharmaceutical, if it weren't for this 'ibumab', I would probably be seventeen years old now!"

"My life was saved by Qingshan Pharmaceutical, so please draw my blood. I am willing to give everything for this improvement plan!"

With a loud bang, an indescribable shock suddenly exploded in Wei Tian's heart.

At this moment, a childish voice suddenly rang out.

"Uncle, I am willing too. Please draw my blood. I am not afraid of pain!"

Wei Tian looked in the direction of the voice. He remembered the child's name - Zhang Lele, eight years old.

"Boss, I'm willing too! Take my bone marrow! I'm a man and I can't be worse than a child!" "Yes! I'm willing too! Isn't it just a blood draw? Isn't it a bone marrow biopsy? I've been through the gates of hell twice, so I'm dead!"

"Damn it! I'm willing to die!"

The crowd was excited, and the shouts of "I do" instantly broke the tranquility of the ward and echoed throughout the department.

Wei Tian's eyes were moistened unconsciously, and the shock in his heart was beyond words.

You can say that their ultimate goal is to hope that Tsingshan Pharmaceutical can develop drugs to cure their diseases, but when they really know that it is extremely painful and may very likely affect their bodies or even their lives, they are still willing to stand up frankly and proactively. Doesn't it take tremendous courage?
As that sentence says:
A true warrior is one who dares to face the bleak life and the blood!

They are all true warriors!
Wei Tian's moist eyes scanned every "screaming" patient, and finally his gaze fell on Xia Xue.

Xia Xue's hair, which had been shaved off due to chemotherapy, has gradually grown back. At this moment, she no longer looks like a patient suffering from leukemia.

It's no different from a normal person.

And she happened to be the one who responded best to "ibumabulin" among the 90 patients, and was also the only patient mentioned by Wei Tian who achieved a % treatment effect after two injections of the preparation.

In other words, Xia Xue's blood sample and bone marrow tissue are actually the most valuable for analysis!

Xia Xue also noticed that Wei Tian's eyes fell on her. Before Wei Tian could speak, she smiled slightly and said first:
"Boss Wei, don't ask me, I am willing!"

"I'm only 25 years old. I don't want to take medicine for the rest of my life! I'm waiting for you to develop a drug that can completely cure leukemia!"

Wei Tian took a deep breath, and for the first time a happy yet unusually heavy smile appeared on his face!

After a moment, he straightened his back, slowly glanced at all the patients present, and finally, he bowed deeply to everyone.

“Thank you for your support!”

"Don't worry, Qingshan Pharmaceutical will do its best to live up to your trust!"

This scene.

call!
Everyone breathed a sigh of relief!

"Boss Wei, Qingshan Pharmaceutical, please!"

……

Wei Tian and even Director Hu had never expected that this improvement plan would be so smooth and would actually receive the full support of all 32 independent medication patients!

Even if we look at any clinical trial of a cancer targeted drug in the world, it is difficult to obtain tissue and blood specimens from so many patients in the same batch at the same time under almost exactly the same medication environment.

This is extremely helpful in finding the differences in the effects of drugs on different individuals. It can be said that this is the convergent R&D environment that all pharmaceutical companies dream of!
However, everyone's enthusiasm was soon tortured by the almost harsh monitoring.

At eight o'clock in the morning, just as I woke up from the hospital bed, the nurse came to the bed with a treatment tray and started the first venous blood draw of the day.

After five tubes of 5ML each, the first blood draw in the morning was completed.

But this is just the beginning. Next, an electrocardiogram and color ultrasound test will be conducted at nine o'clock in the morning. At the same time, all urine and feces must be saved in separate batches and immediately sent to the nurse station, and then sent to the laboratory for testing by professionals.

At two o'clock in the afternoon, the second blood draw of the day began, also 5ML tubes, also five tubes.

At four o'clock in the afternoon, the first bone marrow puncture in seven days began. During the bone marrow puncture, five milliliters of bone marrow fluid will be extracted from the bone marrow.

From this point on, no movement on the ground will be allowed for the next ten hours.

At 5 o'clock in the evening, an electrocardiogram was checked before going to bed, and blood was drawn for the third time of the day, also five tubes, and each tube was mL.

At two o'clock in the morning, when I was still deep in sleep, the nurse drew blood for the last time of the day, the same amount, five milliliters in each tube.

So far, the subjects participating in the improvement plan have had their right arm vein punctured four times a day, and tomorrow they will have their blood drawn from their left arm.

Frequent blood draws four times a day are a huge psychological pressure for any patient. What's more painful is that

25 ml at a time, 4 times a day, 100 ml of blood is drawn a day, which is a considerable amount of blood loss for leukemia patients who are almost all anemic.

And they have to carry out such monitoring for 7 days, which requires losing a total of 700ML of blood, which is undoubtedly a very dangerous amount of blood!
And this is just the average subject.

As Xia Xue had the best effect from the medication, she naturally became the focus of analysis, and the pain she endured was even more heartbreaking.

"Bed 45, Xia Xue, blood drawn."

Old Xia heard the nurse's gentle call beside the bed and woke up from his nap in a daze.

Soon, he reacted.

It was two o'clock in the afternoon, which was just over an hour ago. Didn't I just have my blood drawn? Could it be that I had taken a nap and it was already eight o'clock in the evening?

But when he took out his cell phone and looked at it, it was only 4 o'clock in the afternoon.

He quickly put his phone back and looked at his daughter. He saw that the nurse had already placed the treatment tray on the bedside table and began to tighten the cuff for Xia Xue.

He said anxiously:

"Ms. Nurse, didn't you say that you only draw blood every six hours? Why are you drawing blood again in just two hours?!"

The nurse stopped what she was doing and looked at Lao Xia.

"We just received a notice from the laboratory asking us to draw blood immediately and send it to the laboratory quickly."

When he heard that it was a notice from the laboratory, Lao Xia fell silent.

After a moment, his voice lowered a lot:
"So how much blood do we need to collect this time?"

"Five tubes totaling 25 milliliters!"

Old Xia sighed heavily without saying a word.

During the meeting two days ago, he still thought Xia Xue was very brave, but now he actually saw tube after tube of blood being drawn from his daughter's body, being woken up from her sleep by nurses again and again, and even her face showing obvious symptoms of anemia!

He really feels distressed!

I feel sorry for my daughter!

But... he also knew the importance of Qingshan Pharmaceutical's improvement plan this time!
"Xiaoxue..."

Old Xia looked at Xia Xue with painful eyes, but Xia Xue forced a smile on her slightly pale face:
"Dad, it's okay, I can still hold on, I'm fine!"

Old Xia felt as if his heart was broken by a knife, and finally he sighed:
"Xiaoxue, you are great."

"Pick it!"

The deep red blood slowly flowed from Xia Xue's veins into the cold blood collection tube. In the sunlight, Xia Xue's face seemed even paler.

Old Xia in the distance looked at his daughter silently. He was in pain, but he never thought of quitting, never thought of giving up!
Because they all know that at this moment, the only hope is to firmly believe in Qingshan Pharmaceutical.

Hope to survive!
(End of this chapter)