After being fired, I became the light of medicine

Chapter 247 The real truth—acute rejection!
at noon.

In Zhang Yang’s office at Qingshan Pharmaceutical.

Zhang Yang slowly opened his eyes. After a moment, he took out his cell phone, looked at the time on the screen, and then got out of bed.

After Qin Xiaohua discovered TEF glycoprotein last night, he took the initiative to work overtime with Dr. Zhou and Wei Tian, ​​conducting a 9-hour experimental analysis.

By 8 o'clock in the morning, he could no longer bear it and simply went back to the office to rest for a while.

Seeing that he had slept for 4 hours, Zhang Yang was no longer sleepy. After packing up a little, he prepared to go to the drug research and development center again.

The sound of Zhang Yang getting up in the office fell into the ears of the office assistant Xiao Chen. When Zhang Yang pushed open the door and walked out of the office, assistant Xiao Chen appeared at the door.

"Mr. Zhang, you've only rested for 4 hours. Do you want to rest for a while longer?"

"No, 4 hours is enough!"

Zhang Yang shook his head and continued after a moment:
"Is there any new news from the Drug Development Center?"

"no."

"Ok."

Zhang Yang was not surprised. As he spoke, he quickly walked towards the elevator.

Just entering the elevator:

"Xiao Chen, I'm going to the drug research and development center now, so you don't have to follow me."

"How about this, go to the cafeteria and get me some food. I'm a little hungry!"

"Okay Mr. Zhang."

After arranging for the office assistant Xiao Chen, Zhang Yang quickly came to the first-floor office area where the first project team of Qingshan Pharmaceutical R&D Center was located.

The office area was crowded with people at this time, and dozens of R&D personnel of the "Ibeumab" project were busy. He immediately looked to the innermost part of the office area, which was a small cubicle where Dr. Zhou was.

After a moment, there was some surprise in his eyes. He not only saw Dr. Zhou, but also saw Wei Tian.

He hurriedly walked over.

"Zhou Bo, Wei Tian, ​​haven't you rested since I left? You've been working for more than 24 hours straight!"

Zhang Yang's appearance startled the two of them. Zhou Bo then smiled and replied:
"Mr. Zhang, it's okay. I'm not that sleepy. I really can't sleep unless I figure out the situation of this TEF glycoprotein."

Wei Tian on the side was even more concerned about Zhang Yang:
"Boss, you've only rested for a while, right? Do you want to go to sleep for a while?"

"Don't worry, Dr. Zhou and I are here, we can do it."

Zhang Yang exhaled deeply and shook his head.
"I won't sleep. I've been thinking about this too and can't sleep."

As he spoke, he looked back at Dr. Zhou and said seriously:

"Zhou Bo, I understand how you feel, but we can't fight like this. Our bodies are the capital of the revolution!"

"You go and rest now. And you, Wei Tian, ​​go back and rest together. Leave the things here to me."

Seeing Zhang Yang's face gradually becoming serious, both Wei Tian and Dr. Zhou couldn't help but feel a little fear.

After a moment, Dr. Zhou lost his relaxed smile and said:

"Okay, Mr. Zhang, I'll listen to you."

"But please let me know the final test result before I leave. Five minutes at most."

Zhang Yang's serious expression finally relaxed and he nodded.
"Well, after seeing the results, you have to go home and rest. I'll ask my assistant to take you there."

Having said that, Zhang Yang sat down and turned to the main topic:

"Before eight o'clock this morning, we have confirmed the action principle and operation mechanism of 'TEF glycoprotein'!"

"How is the situation now?"

"Have you discovered the reason why Xia Xue's body has a high concentration of TEF glycoprotein in these four hours?"

"Is it because, as we expected, the concentration of CD8+T cells, a subset of immune cells in Xia Xue's body, is higher than that of other patients? So the concentration of TEF glycoprotein is high?"

"No."

After the words fell, Wei Tian glanced at Dr. Zhou and slowly shook his head.

After a moment, he picked up a stack of reports from the desk and handed it to Zhang Yang.

"Boss, this is the newly released experimental data analysis report!"

"Just after you went to rest, a colleague came to work. Zhou Bo and I immediately arranged for each R&D team to start experimental verification according to our expected ideas."

"But after analyzing the blood samples of ten patients, we found that even for patients whose treatment effect was only 51%, there was no significant difference in the concentration of CD8+T cells in their blood and that in Xia Xue's blood!"

"No noticeable difference?!"

"you sure?!"

"Yeah, I'm sure!"

Zhang Yang was stunned. This result was completely beyond his expectations!

After a moment, he took the experimental report handed over by Wei Tian in surprise. After quickly scanning a few pages, he couldn't help but put on a mask of pain on his face.

According to normal logic,

Since TEF glycoprotein is secreted by immune cells CD8+T cells, the higher the number of CD8+T cells in the blood, the more TEF glycoprotein will be produced and the higher the concentration.

Yes, that’s the logic!

But now!
It is clear that the TEF glycoprotein in Xia Xue's body is significantly higher than that of other patients, but the immune cell data is basically the same as other patients!
This!
what happened?

Zhang Yang suddenly found himself in a dead end.

At this moment, Dr. Zhou on the side coughed lightly. It was obvious that he had experienced a period of confusion like Zhang Yang, and seemed to have found a reasonable explanation.

"Mr. Zhang, when we first got the experimental results, we were just as skeptical about life as you are."

"However, after I looked up some information related to leukemia, I found that leukemia patients, especially those with severe leukemia, have long-term erosion of the body due to leukemia, coupled with the effects of chemotherapy and radiotherapy. In the later stages, the immune cells in the body will be reduced to below the normal value of ordinary people. This is why all leukemia patients are prone to infection, because their immune systems have been damaged!"

"So, if Xia Xue's immune cells are really far more than other people's, it would be abnormal. Just imagine, if Xia Xue's immune cells are extremely numerous and highly concentrated, then she can kill the leukemia cells with her powerful immune cells, and it won't become a serious illness!"

Dr. Zhou's explanation is easy to understand.

Indeed, the typical symptoms of leukemia patients are low immunity and immune cells being in a state of shutdown.

But this made Zhang Yang even more confused!
It is so strange that low numbers and low concentrations of immune cells actually produce high concentrations and high quantities of TEF glycoprotein secretions!

Isn’t TEF glycoprotein related to the number of immune cells?
what is that? !

Zhang Yang had no answer.

His eyes inadvertently fell on Wei Tian and Dr. Zhou. He also knew that Dr. Zhou and Wei Tian must not have the answer!

Thinking of this, he took a deep breath. It seemed that he still had to search for the truth of TEF through experiments one by one.

At this moment, Xiao Chen, the office assistant I had previously instructed, hurried in with a box of lunch. He walked quickly to Zhang Yang and said:
"Mr. Zhang, I prepared some food for you in the cafeteria. Do you think it suits your appetite?"

Zhang Yang couldn't eat at this moment, he waved his hand without even looking at it and said:

"Put it aside for now!"

As he spoke, he looked at Wei Tian who was standing aside and said:

"Wei Tian, ​​please show me the information of all the patients participating in the improvement plan this time. I need to sort out the clues again!"

"Go home as soon as you find it! And Zhou Bo, the experimental data you've been waiting for has come out, right? If there's no major discovery, go home as soon as possible!"

"Xiao Chen, arrange two drivers to take Director Wei and Zhou Bo home!"

"Okay, Mr. Zhang."

Following Xiao Chen's answer, Dr. Zhou couldn't help but smile bitterly. After a moment, he nodded and said:
"Okay, Mr. Zhang, I'll just pack up and go back to rest."

"Ok!"

Dr. Zhou began to pack up his things, and Wei Tian also found a copy of all the subject information data from a pile of information and gave it to Zhang Yang.

Zhang Yang lowered his head and began to look up the information.

There are 32 subjects in the improvement plan, and the first patient is Xia Xue.

[Xia Xue, female, 25 years old, one week after injection of 'Ibetumumab', the number of leukemia cells in the body decreased by about 85% (estimated by CT-PET data), two weeks later, the number of leukemia cells decreased by 91%. (Bone marrow puncture smear), three weeks later, maintained at 91%. ]

【Cheng Wei, male, 26 years old, one week after the injection, the number of leukemia cells in the body decreased by about 79% (CT-PET), two weeks later, the number of leukemia cells decreased to 85%, and three weeks later to 84.6%. 】

[Xu Guanghua, female, 18 years old, one week after the injection, the number of leukemia cells in the body decreased by about 76%. After two weeks, the number of leukemia cells decreased to 82%, and after three weeks, it decreased to 82.6%. ]

【…】

Zhang Yang checked them one by one.

Xia Xue's treatment effect was the best among the 32 people in this batch, followed by a 26-year-old man named Cheng Wei, and then an 18-year-old girl.

After seeing all 18 patients, Zhang Yang did not find any patterns or abnormalities. If he had to say something, it would be that the first ten patients were all between 30 and years old, all very young.

But this obviously cannot become a rule.

Soon, the thin stack of patient information was turned to the last two pages.

【Patient medical records.】

[Xia Xue: Five years ago, the patient underwent the first bone marrow transplant, and the donor was the patient's father. Five years later, in June this year, a reexamination found that the disease had relapsed. After three months of chemotherapy, a second transplant was performed.]

[The operation went well, but two months after the operation, acute rejection suddenly occurred and could not be controlled. One month after the acute rejection, I received a clinical trial of Ibelumab.]

【Cheng Wei: I had my first bone marrow transplant four years ago. The donor patient was my mother. One year after the operation, I developed chronic rejection symptoms. After three years of drug control, the transplanted bone marrow stem cells became inactive and the leukemia completely relapsed. I then received treatment in a clinical trial of Ibelumab.】

[Xu Guanghua: I had a bone marrow transplant three years ago. One month after the operation, I developed an infection, followed by chronic rejection. Two years later, the transplant failed and the leukemia recurred. I then received treatment in a clinical trial of 'Ivolumab'.]

Zhang Yang still read the detailed medical records of each patient very carefully, but after reading from beginning to end, he still did not find anything abnormal.

Since all the patients who took "ibukumab" independently were critically ill patients, all the subjects had received at least one bone marrow transplant, and eventually either the transplant failed due to rejection, or the leukemia relapsed directly after surgery.

After all, if there is no recurrence or rejection, it means that the patient has been cured and has become a normal person. How can he possibly participate in any clinical trial?

So, everyone’s medical records are actually similar.

Thinking of this, Zhang Yang was really puzzled.

"Rejection and relapse are common conditions for all test subjects, and Xia Xue's medical records are no exception. But what exactly causes Xia Xue's blood TEF glycoprotein to be higher than others?"

As he spoke, he frowned and slowly turned to the next page.

But just as he finished speaking, his expression suddenly froze, and the page he had turned over suddenly turned back again.

Zhang Yang's gaze fell directly on the first line of Xia Xue's past medical records.

[Xia Xue: Five years ago, the patient underwent the first bone marrow transplant, and the donor was the patient's father. Five years later, in June this year, a reexamination found that the disease had relapsed. After three months of chemotherapy, a second transplant was performed.]

[The operation was completed well, but two months after the operation, acute rejection suddenly occurred and could not be controlled. One month after the acute rejection occurred, I received a clinical trial of Ibelumab. ]

Acute rejection!
This time, Zhang Yang's attention was directly focused on the four words "acute rejection"!

The next second, his eyes quickly moved downwards, and the more he looked, the more shocked he became!
【Cheng Wei: Chronic rejection.】

【Xu Guanghua: Chronic rejection.】

【Zhang Lele: Chronic rejection. 】

【Liu Xiaochuan: Chronic rejection! 】

!!!

Except for Xia Xue, all the 32 subjects who participated in the clinical trial and used the drug independently suffered from chronic rejection!
Correct!
Chronic rejection!
The sudden discovery was like a ray of light in the darkness that instantly illuminated his confused mind. The sharpness of a top drug developer allowed him to react in an instant!

This kind of sensitivity made him not even need to think too much, and a complete set of logical closed loops instantly emerged in his mind!
Qin Xiaohua's conclusion is actually wrong, or incomplete.

"TEF glycoprotein" is indeed secreted by immune cells D8+T cells, but!

The number of immune cells will not increase the concentration of TEF glycoprotein. What can really affect TEF glycoprotein should be the acute rejection reaction!
Correct!
Acute rejection reaction!
Zhang Yang’s mind exploded instantly, and all his thoughts became extremely clear!

What is acute rejection? !

To put it simply, when the human immune cells discover foreign substances, they begin to kill the invaders frantically!

At this time, the immune cells will run at full speed, commanding the brain center to mobilize a large amount of energy substances in the body to provide them to the immune cells!

why!
Because immune cells need to work, they consume a lot of glycogen and energy!
Once the immune cells begin to activate and produce an immune rejection reaction, the rate of proliferation and metabolism of the immune cells will be several times or even dozens of times higher than normal!
Correct!
Especially the metabolic rate!

When immune cells need to kill target cells, they need to release cytotoxic substances such as perforin and granzymes through exocytosis. This process requires ATP to provide energy.

in other words!

The faster the immune cells metabolize, the more perforin, granzyme and other substances they secrete, and the stronger the immune cells are!

And it just so happens that TEF glycoprotein is the metabolite of immune cells!
"That makes sense, that makes sense!"

"The reason why the concentration of 'TEF glycoprotein' in Xia Xue's body is so high is because she was still experiencing an 'acute rejection reaction' three weeks before she participated in the clinical trial. Therefore, a large amount of the metabolite of the acute rejection reaction - TEF glycoprotein - appeared in her body!"

As for why the TEF glycoprotein in patients with chronic rejection is not so high, it is because although chronic rejection is also rejection, the degree is mild and the metabolism of immune cells in the body is not acute and intense, so the TEF glycoprotein is controlled in a relatively stable metabolic state!
As for why, except Xia Xue, there was no other patient with acute rejection reaction among the 32 subjects.

As soon as this thought appeared in Zhang Yang's mind, he got the answer instantly.

If Xia Xue had not met Director Hu by chance and had not received "ibumabucil treatment" immediately, she would have died at this moment.

That's right.

Compared with chronic rejection, the mortality rate of patients with acute rejection is extremely high...

Those patients with acute rejection died before they could receive involucrumab.

Xia Xue is just one of the lucky ones!

(End of this chapter)