A genius? I just love studying.

Chapter 322 Disagreements within the Nobel Prize Committee
Liu Jishou's laboratory,

Based on the data obtained from these days of experiments, Chen Hui has come to a bold conclusion: the core reprogramming action of the Nirvana program may have unexpectedly and systematically reversed the age-related epigenetic changes.

To verify this, he began a frantic process of modeling.

He integrated a large amount of data from the transcriptome, epigenome, and proteome before and after the Nirvana treatment to construct a hyperdimensional cloud map of cellular state changes.

The algorithm is used to infer the motion trajectory of each processed cell in the state cloud map.

The results showed that their trajectories did not simply point to the two endpoints of differentiation or apoptosis, but rather they jointly experienced a peculiar recovery state space along the way, a direction in which all indicators showed a younger and healthier state.

Chen Hui attempted to reverse engineer the process to find which component in the Nirvana program was responsible for this unexpected effect. Through complex perturbation analysis and simulation of deleting or modifying loop components in a computer model, he pinpointed the source to the self-destruct pre-repair and verification module designed to ensure safety.

The purpose of this module is to check and repair any minor DNA damage that may be caused by genetic manipulation before the program self-destructs, ensuring that no problems remain.

However, Chen Hui's model shows that the energy and precision of this repair process unexpectedly reached a threshold that could simultaneously erase deeper epigenetic scars. It was like a precise laser that not only repaired the immediate crack but also removed the stains that had accumulated on the wall over the years.

This is not an error!
Chen Hui can confirm that while the Nirvana Program successfully resets the fate of cancer cells, its core reprogramming power inadvertently erases the epigenetic noise accumulated by cells during the process of carcinogenesis and aging.

It's like a high-end biological eraser, not only erasing the wrong cancerous graffiti, but also fading away some wear and tear marks that represent aging.

He discovered that the self-destruct switch in the Nirvana process, which ensures a one-time effect, triggers a series of extremely delicate DNA repair and chromatin remodeling activities before it is activated.

The intensity and timing of this activity are just right, sufficient to repair the enormous damage caused by cancer, but not to the point of completely rejuvenating cells to an embryonic state like induced pluripotent stem cell technology, which would lead to loss of control and the risk of tumorigenesis.

It seemed to push the cells to a critical point of recovery, and then stop precisely. At this point, Chen Hui could only marvel at the wonder of creation, something he had never considered when designing Nirvana.

Chen Hui examines all of this from a higher perspective.

He realized that cancer and aging share some of the same underlying pathways, such as the accumulation of DNA damage, abnormal telomere function, and epigenetic dysregulation.

His Nirvana gene circuit is essentially a powerful reset and repair of the cellular information system. Since it can repair the most extreme system collapse, such as cancer, can it also repair the slow system wear and tear, such as aging?

A vision far grander and more fundamental than curing cancer slowly unfolded before him.

We have been pursuing cures for diseases, but that only brings the negative value to zero. Nirvana, on the other hand, may point to another possibility... not just zeroing it out, but significantly extending the health balance of life.

This is a viable direction, not a fantasy of immortality!
Based on the experimental data from these days, Chen Hui began intensive research, referring to the core principles of the Nirvana system, to develop a highly controllable, localized epigenetic resetting therapy.

This therapy is not intended to treat cancer, but rather to reverse age-related degeneration in specific tissues, treat other diseases closely related to aging, and extend healthy lifespan.

Its ultimate goal may not be to allow people to live to 200 years old, but to allow a person to still have the physiological functions and quality of life equivalent to a 50-year-old or even a 40-year-old when they are 80 years old, compressing disease and weakness into the very short period of time at the end of life.

According to Chen Hui's calculations, without external interference, humans should be able to easily live past 150 years old after using Nirvana II!
"More experiments are needed to verify this."

Chen Hui muttered to himself and immediately summoned Liu Jishou to begin designing the next step of the experiment.

After these days of experiments, one impressive set of experimental data after another has been presented to everyone. They have long been completely impressed by Chen Hui and are now in a state of high enthusiasm. They would be willing to do experiments all night long, let alone conduct them.

……

After a busy day at the Max Planck Society in Germany, Schulz returned home and collapsed onto his soft bed as if a mountain of gold and jade had been overturned.

He's been so busy these days.

When he saw the plasma confined in the vacuum chamber like obedient rabbits, creating streaks of brilliant colors, Schultz suddenly understood why Chen Hui wanted to study controlled nuclear fusion.

After digesting the technology provided by China, they have independently built their first nuclear fusion power plant. When this news was released by the national media, the whole of Germany and the entire West were in an uproar.

This shows that not only is China's technology feasible, but others can also learn it!
In a short time, numerous high-ranking officials from various countries flocked to China to negotiate cooperation matters.

They all understood the changes this would bring to the world. The first industrial revolution was due to the invention of the steam engine, the second industrial revolution was due to electricity, and nuclear fusion energy could be considered the catalyst for the third industrial revolution.

Everyone knows the earth-shattering changes that the First and Second Industrial Revolutions brought to the world, and they also know the fate of those countries that fell behind in the Industrial Revolution.

They were determined to seize this third opportunity.

However, Schultz didn't think that far ahead. His current work is to improve plasma motion prediction models and try to develop the next generation of controlled nuclear fusion based on Chinese technology.

This was no easy task. Even as a genius mathematician, he often felt his mind go blank and he had no clue what to do. The high-intensity, long-term research left him somewhat exhausted.

But after lying in bed for more than ten minutes, he still forced his tired body to go into the study. He would study cutting-edge mathematical theories for several more hours before going to sleep.

Everyone knows he's a math genius, but few know how much effort he put into achieving it.

There are many geniuses in this world, but who among them who has achieved something has not worked as hard as him?
He heard that Chen Hui only slept three hours a day and studied mathematics while eating and sleeping. He tried it for a while, but that attempt almost landed him in the ICU, so he had to give up decisively.

Humans are indeed no match for demons.

Sitting at his desk, Schultz put aside his distractions, logged into arXiv, and began browsing new papers in his subscribed field to see if there were any interesting articles.

Two hours later, he opened his email and began processing the emails that had come from various sources that day.

Suddenly, he saw the news that his subscribed journal, "Huaxia Mathematics," had been published.

I checked the time, and today isn't the publication date.

"Could it be some major breakthrough?"

Sure enough, Chen Hui had been keeping quiet for so long; he must have been preparing a big move.

Schultz thought excitedly and couldn't wait to open the official website of Huaxia Mathematics. He then saw the cover paper, "Cancer Treatment Based on Reprogrammed Gene Circuits".

The first author is undoubtedly Chen Hui, while Schultz is not familiar with the others.

This is different from the last paper, where Chen Hui was only the third author and may have only participated in the research. But this time, it must be the research led by Chen Hui.

Based on Schultz's understanding of Chen Hui, since Chen Hui was willing to publish a paper, there was only one possibility: he had completely cured his cancer!

Schultz's heart pounded; the achievement was simply too astonishing. He had to take some time to calm himself before looking at the abstract.

Treatment of advanced cancer has long been limited by tumor heterogeneity, drug resistance, and the toxicity of traditional therapies. Despite advances in targeted and immunotherapies, the vast majority of patients ultimately face disease progression. We propose a novel treatment paradigm aimed at fundamentally reprogramming the fate of cancer cells, rather than simply killing them…

Schultz wasn't a biologist, so he only skimmed the paper, treating it like a popular science article, without delving into it, and therefore didn't spend much time on it. An hour later, after finishing the paper, Schultz gasped in astonishment.

Chen Hui actually solved the problem.

A mathematician solved the problem of cancer.

It's kind of ridiculous to think about it.

But if this happened to Chen Hui, it would seem quite reasonable.

Chen Hui published a lot of data in the paper, but the specific details of the gene circuit were not included. Song Chaoming has a dedicated team to develop a patent for him, and the drug has been reported to the relevant authorities.

Chen Hui did not intend to make a lot of money for himself like gallium oxide, as he already had no shortage of resources given his current status.

He had already negotiated with the relevant departments that the patent could be transferred to China for use free of charge, with only one requirement: the final product must be as cheap as possible.

Of course, if the West wants to use it, they'll have to obediently pay the patent fees.

……

Dana-Farber Cancer Institute

The person in charge, Diana, is vacationing on Brache Island, enjoying the sun, sand, and sea.

Last year they achieved a major breakthrough, and the next step is naturally to find the right direction. She has always believed that only a well-rested brain can generate sufficiently creative ideas, and she also firmly believes that working hard in the right direction is far better than working hard blindly.

Therefore, she is always very cautious in choosing research topics, and she will only start research after very rigorous argumentation. So, since the results were published last year, there are naturally teams in the institute that continue to carry out follow-up research, but she has not started a new research topic for more than a year.

She came to Brachi Island to relax her mind and hopefully find the right topic.

In the words of artists, her approach is called "field research."

As night gradually fell, she dragged her sun-baked, lazy body back to the hotel, her feet sinking into the warm, soft sand.

Back at the hotel, she took a shower, changed out of the bikini that showed off her amazing figure, and put on a comfortable silk nightgown.

Only then did she pick up her phone from the bedside table; it was obviously inconvenient to carry a phone while wearing a bikini on the beach.

The moment she turned on her phone, more than twenty missed calls appeared, all from her deputy.

"Annie, what's wrong? What's the rush?"

The moment she dialed back, the call connected, and Annie's anxious voice came through the receiver, "Director, please take a look at the latest paper from Huaxia Mathematics."

"Chinese Mathematics?"

Diana asked in surprise. Although she had seemed dismissive during the interview, it was, after all, a journal founded by a legendary mathematician like Chen Hui. After discovering Song Chaoming's paper, they still paid attention to Chinese mathematics.

"That's right, it's China Mathematics. They've found a way to completely cure cancer."

Anne summarized it for her directly.

"how is this possible?"

Diana was speechless, and even found it somewhat amusing. "Could it be data fabrication? The Chinese really like doing these kinds of things."

She studies this very thing; how could she not know how difficult it is?

She was certain that in this era, in this world, no one could possibly find a way to completely cure cancer.

"Why don't you take a look at the paper first?"

Anne said no more. Based on her understanding of Chen Hui, she did not believe that the data was fabricated, and from a biologist's intuition, the data could not possibly be fabricated.

Diana picked up the tablet from the side, went to the Huaxia Mathematics website, found the latest issue, and easily saw the article Anne had mentioned.

Click to start reading.

Soon, when she saw that Chen Hui was the first author of the paper, her expression changed.

She knew that given Chen Hui's status in academia and his age, it was impossible for him to fabricate anything, because he had an unlimited future ahead of him.

In other words, this paper is real!
Diana felt her heart skip a beat as she thought about what she had said at the press conference, and heaven knows what the media was saying about her now.

Diana's face turned pale and then red, but she quickly recovered; after all, she was a seasoned veteran.

This left her feeling somewhat lost. If Chen Hui had completely solved the cancer problem, what would become of her after a lifetime of researching cancer?

……

Stockholm, Sweden, Nobel Prize Committee

Kathy Kuleman-Pfeiffer sat in the conference room, her brow furrowed, deep in thought.

"If the Nobel Prize is not awarded to Professor Chen this time, the world will probably laugh at our review committee."

"Judge Svenberg said anxiously."

This time, no one objected. If the achievement of completely curing cancer cannot win the Nobel Prize, then their Nobel Prize will undoubtedly become a joke.

However, what made Pfeiffer hesitate was...

Generally speaking, the Nobel Prize in Physiology or Medicine is awarded annually, once for biology and once for medicine. Last year it was awarded to medicine, so this year it should be biology's turn.

Furthermore, this award is selected by the Karolinska Institute's review committee, and this year's winners have been determined, deciding to award it to American scientists Victor Ambrose and Gary Ruffkun in recognition of their discovery of microRNAs and their role in posttranscriptional gene regulation.

They had even informed the two of the award.

The sudden change of personnel seems somewhat inconsistent, especially since Chen Hui has already won the Nobel Prize in Physics this year. If he were to win the Nobel Prize in Medicine as well, winning two Nobel Prizes in the same year would be unreasonable.

(End of this chapter)