MYGO's guitarist has ice attribute bonus

"It's okay, Ai, relax." Xiangzi sat down beside Aine's bed. "The result will definitely be the same as last time, so don't worry."

"Of course." Aine nodded. Yesterday, Dr. Yamada told her to prepare for the surgery tomorrow. He also told her that the first surgery was not a failure, but the removal effect was not complete.

This sentence soothed Aine's anxious heart. For her, as long as it worked, it would be fine. Wouldn't that prove that her ALS was getting better little by little?

Aiyin smiled, agreeing with Xiangzi: "The first time was fine. The second time is just to clean up the leftovers, so it will definitely be fine too."

As Aiyin finished speaking, Dr. Yamada walked in with other doctors.

It is true that Dr. Yamada is Aine's attending physician, but because other neurologists often come to help, Aine can't remember their names, but she knows their faces. However, this time, there are many unfamiliar faces.

"Aine's mother, please step aside for a moment. We are about to begin the operation."

After Aine's mother and the others left, Aine blinked and said in confusion, "Doctor Yamada, there are so many doctors I don't recognize here this time."

"She's from another department." Dr. Yamada signaled the nurse behind him to help Ai Ne lie flat.

"Other departments?" Aiyin nodded and did not ask any further. She did not understand the hospital's rules and regulations, nor was she interested in learning about them.

Just like the initial genetic programming process, after completing all preparations, Dr. Yamada slowly pushed the needle into Aine's lumbar spine.

After Dr. Yamada had pushed all the injection in, he pulled out the needle, stopped Aine's bleeding, and laid her flat to prevent the cerebrospinal fluid from leaking out.

Aiyin lay flat on the bed and closed her eyes. She didn't know why, but her head always felt a little dizzy.

"Doctor Yamada, the patient's physical data is somewhat abnormal."

The nurse's sudden voice startled Dr. Yamada. A doctor standing beside the nurse leaned over to the instrument and asked, "Is the C-reactive protein level continuing to rise?"

"What?" Hearing this, the other doctors were stunned.

Doctor Yamada came to the continuous blood monitoring device and looked at the data on it with a frown. He turned back to look at Aine: "Chihaya-san, do you feel anything now?"

“I feel… a headache and nausea.” Aine’s voice was weak.

Hearing this, a doctor from the critical care unit walked over to Aine's bedside and gently opened her eyes. The next moment, he turned to look at the other doctors and said, "Go to the CT room. It's likely that the AAV vector caused vascular inflammation, leading to intracranial hemorrhage."

At this point, he looked at the nurse next to him and said, "Go get some tranexamic acid."

"it is good."

After the doctor in the intensive care unit said the words "intracranial hemorrhage", the other doctors did not think too much. After putting down the pulley, they hurriedly pushed the bed to the nearest CT room.

The doctor standing by the door opened the door for them and hurriedly left the ward.

When Xiangzi and the others who were sitting on the bench waiting for the operation to be over saw this scene, they were stunned.

"This...what happened to Aine-chan?" Su Shi was stunned as the doctors disappeared around the corner.

Aiyin's mother came to her senses and called out to the nurse walking at the end: "Nurse, please tell me, what happened to my daughter?"

"Intracranial hemorrhage, go to the CT room now to confirm the amount of bleeding and the location of the damage." After the nurse said this, she hurriedly followed.

"Intracranial hemorrhage..." Deng bit his lower lip tightly.

Mu watched the doctors disappear around the corner, his entire body trembling uncontrollably: "Aine-chan..."

“It was fine the first time, why is it like this time…” Xiangzi lowered her head, her eyes full of confusion, her mind filled with the conversation she had just had with Aine.

Xiao Ai was smiling so brightly just now, but now... why is it like this?

Several doctors pushed Aine into the CT room. After the doctors in the radiology department saw this scene, they also knew that it was an emergency, so it took no more than ten minutes for Aine to enter the CT room and get the results.

"The amount of bleeding and the location of the damage have been determined," the radiologist told Dr. Yamada. "Surgery is necessary."

The doctor from the critical care unit looked at Dr. Yamada and said, "Then wait until the neurosurgeon finishes the operation on the child and then send him to us."

"I understand. After the intracranial hemorrhage surgery, I will naturally be monitored in the ICU for the first few days."

The nurse rushed into the CT room and said, "Dr. Yamada, the neurosurgeon is already in the operating room."

"Okay." Dr. Yamada glanced at Aine lying on the hospital bed. "Then let's ask the neurosurgeons to help. Talk to them about controlling bleeding and protecting nerve function while maximizing the effects of gene editing."

"I did." The nurse nodded. "I also told you how to do it."

"That's good." Dr. Yamada nodded, but his heart was still hanging.

I hope this operation can keep the carrier retention and editing efficiency above 50%, otherwise... it will be a waste of time.

Chapter 342 Misfortunes never come singly

After hanging up the phone with the neurology nurse, the neurosurgery nurse ran into the operating room and told the surgeon everything that had just happened.

After hearing the nurse's words, several doctors waiting in the operating room fell silent.

Not long after, a bespectacled doctor spoke up: "Tsk, those old guys in the neurology department, do they think we're superhuman?"

"To maximize the effects of gene editing, the surgery must be performed under a hypothermia treatment environment." Another doctor looked at the nurse. "Is the edaravone ready?"

"Ready." The nurse nodded.

"It's a relief that you're so patient. Neuroendoscopic surgery is tiring enough, and now there are additional requirements from the neurology department." The bespectacled doctor sighed.

"Instead of complaining here, it's better to focus on the next surgery. The patient's condition is the most important thing to us."

"I know."

Although he said this, the optician still knew what was important in his heart. He would just find the group of doctors in the neurology department and give them a meal after being asked to do so during the operation.

"Is the intraoperative MRI adjusted?" Another doctor glanced at the nurse and saw the nurse nod, so he didn't say anything else.

Although they are veteran neurosurgeons with rich experience, the requirements of neurology are indeed a bit high. They want to protect the editing effect while performing intracranial hemorrhage surgery perfectly. In order to be safe, they can only rely on the real-time high-resolution images provided by intraoperative MRI.

It didn't take long before Aine was pushed onto the operating table.

After completing a series of preparations, the doctors began the neuroendoscopic surgery.

Although neuroendoscopic surgery requires high technical skills and is time-consuming, it can avoid the gene editing target area.

Fortunately, these doctors all have decades of work experience, and although it is a bit tiring, the progress is very smooth.

One hour……

Two hours...

Just as everyone was holding their breath and concentrating on the operation, the nurse in front of the instrument suddenly noticed the abnormality in the data. She turned her head to look at the doctor who was closest to the intraoperative MRI. The latter also noticed her gaze and made a silence gesture, signaling the nurse not to speak.

Nodding gently, the doctor spoke quietly to avoid startling the bespectacled doctor who was performing the operation: "The operation is aborted. The patient has a ruptured blood vessel in the brain and is bleeding profusely."

Hearing this, the bespectacled doctor who was still in surgery came to his senses and quickly stopped what he was doing. He stood up and looked at the doctor next to him, his mind already starting to think: "Do we still consider the editing effect?"

The latter reacted quickly and made a judgment almost instantly: "No need, nurse, go out and notify the neurology department, we need to perform a craniotomy."

"Okay, doctor."

"Once the location of the ruptured blood vessel is determined, the intraoperative MRI can be withdrawn."

For them, they have seen at least 800 cases of massive intracerebral hemorrhage during the operation. As long as they do not need to consider the editing effect, they can completely rely on intraoperative MRI to stop bleeding and remove hematomas. It is better to say that intraoperative MRI will only delay their time and increase the risk and complexity of the operation.

Because the doctors had anticipated that something like this would happen, the nurse prepared the electric hair clipper early.

After determining the bleeding site, the nurse removed only a portion of Aine's hair, minimizing the impact on her appearance...

Another nurse walked out of the operating room and called Dr. Yamada.

Dr. Yamada, who was waiting in the conference room, quickly took out his phone when he heard the ringing. After seeing that it was from the neurosurgery department, he answered without hesitation: "Hello, this is Yamada."

"Dr. Yamada, I need to tell you now that the patient has a ruptured blood vessel in his brain, causing massive bleeding. To save his life, we can no longer consider the effects of editing."

"Oh, I see." Dr. Yamada nodded. After hanging up the phone, he leaned back in his chair as if all his strength had been drained away.

Seeing him like this, the doctor from the same department patted his shoulder and said comfortingly, "Okay, Yamada, don't be so depressed. Although they said they won't consider the editing effect, when they check again later, there might still be a lot left."

The doctor from the critical care unit also nodded. "Indeed, Dr. Yamada, there's no need to be too pessimistic. The neurosurgeons are top-notch technicians, and this type of surgery is a piece of cake for them."

Dr. Yamada nodded and stood up. "I'll go find the child's mother and tell her what happened."

"it is good."

After leaving the meeting room, Dr. Yamada returned to the inpatient department and saw several people still waiting in the corridor.

The first time she saw Dr. Yamada, Aine's mother hurried over to stop him and said, "Dr. Yamada, how is Aine?"

"She's in the operating room right now," Dr. Yamada glanced at everyone. "The neurosurgery nurse just told me that Chihaya suffered another ruptured blood vessel in her brain during surgery, causing heavy bleeding. They can only abandon the protective editing effect and perform a craniotomy."

"Craniotomy..." Deng repeated Dr. Yamada's words blankly. Does that mean... Aine-chan's head is going to be opened? How scary... Aine-chan... must be very scared...

Mu was in disbelief: "How could it be..."

Xiangzi clenched his fists: "Then... Doctor Yamada, how is Xiao Ai doing now?"

Doctor Yamada shook his head slightly. Seeing this, everyone else's hearts instantly rose to their throats. Su Shi's body couldn't stop shaking: "Shake your head? It's hard to say that Aine-chan..."

Su Shi did not continue speaking. She did not dare to say anything, fearing that the facts would really be as she guessed.

After hearing what Su Shi said, the others stared at Dr. Yamada and didn't dare to speak.

"I shook my head to say I didn't know." Dr. Yamada realized his actions had caused a huge misunderstanding. He clasped his hands together, bowed, and apologized. "I'm sorry, but please don't worry. Our neurosurgeons are very capable."

“Is that so…” Aine’s mother let out a long sigh. She had just seen Dr. Yamada shake his head, and she almost fainted. “So, how did the second edit go?”

"It's hard to say." Dr. Yamada shook his head. "If there had only been one intracranial hemorrhage, we could have managed to preserve the editing results, but this second hemorrhage has disrupted all plans."

After a pause, Dr. Yamada continued, "Although a craniotomy can save Chihaya-san from danger, it will also have a significant impact on the secondary editing."

"What is the specific impact? Will it be cut in half?" Xiangzi looked confused.

"If it was cut in half, that would be a blessing." Doctor Yamada turned his head and looked out the window. "It's likely that the carrier activity will only be 10% to 20% left."

Chapter 343 ICU

Thanks to the doctors' superb medical skills, after several hours of hard work, they finally stopped Aine's bleeding and completely removed the blood clot.

Although a craniotomy would cause considerable damage to Aine's body, it was still worth it in order to save her life.

"Huh." The bespectacled doctor breathed a sigh of relief. "It's been a while since I've performed such a strenuous operation. How are the patient's vital signs?"

"Doctor, the patient's vital signs are stable."

"That's good." The spectacled doctor nodded. He was very satisfied that he and his friend had saved another life.

Another doctor nodded. "I just don't know how many re-edited vectors are left."

"It can't be helped. If it weren't for this second rupture, we would have completed the surgery long ago."

"Nurse, please tell the neurology department and ask the ICU to come over and get someone."

"it is good."

When the nurse pushed open the door of the operating room, she found that the sky outside had turned orange: "It's evening..."

Because of the instability of intracranial hemorrhage, Aiyin had to be transferred to the ICU for seven days of monitoring. Under normal circumstances, only three to five days would be enough. The reason for the delayed transfer was to prevent rebleeding and cerebral edema, and to determine the editing effect after one week.

As soon as Aine was transferred to the ICU, Dr. Yamada informed Aine's mother of the news.

After hearing the news, although the latter could not go to the ICU to visit Aine, at least he knew that his child was out of danger for the time being, and he finally felt relieved.

In the ICU ward where Aiyin was, there were only a few elderly people besides her, and there were curtains separating each bed, so she felt quiet.

After she woke up, she learned from the nurse what happened during the operation, including that part of her hair was shaved off. Although she was reluctant, facing the desire for life, Aine still accepted this fact.

Fortunately, the nurse told her that the surgical incision was not large and it would grow back after a while.

Thanks to Aine's youth, her condition in the ICU has been very stable. After completing today's hematoma absorption test and confirming whether the editing effect is seriously damaged, she can be transferred to her original single room.

It was still early in the morning when a nurse came in pushing a medical cart. She came to Aine's bedside and called softly, "Little Aine, are you awake?"

"Chihaya Aine" is a person known to almost everyone in the entire NCNP. The reason is very simple - she is the first person to undergo radical surgery for ALS.

Aiyin lay on the bed and said softly, "Nurse, what are you going to do today?"

"We'll do a hematoma absorption test today. If it's normal, you can return to your original ward."

Hearing this, Aine's eyes lit up. Although she had disliked her ward before being admitted to the hospital, that was only compared to the outside world. Now she had been stuck in the ICU for a week, and the only people she could talk to were the nurses or herself.

She now longs to be able to return to her own single room.

“Really? That’s great.” Aine breathed a sigh of relief. “Then when can I get the checkup? Now?”

"Yes." The nurse nodded and connected the instrument to Aine.

Not long after, the nurse removed the device from Aine's body. "The hematoma has been absorbed well, and you can be discharged. Once we determine whether the editing effect has been damaged and remove the stitches on your head, we will transfer you to a private room."

"Well, nurse, do I need to use prednisone to suppress inflammation today?"

The nurse shook her head. "Your condition has returned to normal now. You just need to take good care of yourself. You won't need prednisone, and the remaining carrier activity will not be affected."

Watching the nurse's operation, he said, "I didn't expect that there are instruments in the ICU that can detect the effects of editing."