godfather of surgery

Chapter 1051 The entire army was destroyed
Sisi's high fever continued to persist, and Yang Ping could only temporarily use an ice cap and ice blanket for physical cooling. By the next morning, Sisi still showed no signs of fever going down.

In order to keep the airway open, the nurse has intubated Sisi, and a ventilator, ECMO and other life support equipment are also ready for use when needed.

Yang Ping observed Sisi's condition and thought about countermeasures. There was no precedent to refer to for what kind of reaction this virus would cause to the human body.

The impact of the source virus on the human body is no longer of any reference value, because after the K factor is implanted, the new virus now causes symptoms that the source virus does not have at all. The source virus causes mild flu symptoms at most, but the current K virus actually causes a persistent high fever of 42 degrees Celsius.

Yang Ping's idea is very clear now. Use physical cooling to lower body temperature as much as possible, reduce brain tissue metabolism, and protect brain tissue and other important organs from damage. Maintain Sisi's fluid balance and electrolyte balance, and maintain her normal nutrition and energy supply. As for reducing fever, leave it to the body's own immunity.

These viruses have been castrated of their ability to replicate, so as long as Sisi can survive the virus's own survival time, then after the viruses die naturally one after another, the number of viruses will gradually decrease and the high fever will naturally subside.

This is actually similar to the treatment idea for most diseases. Symptomatic treatment relieves symptoms and ensures life safety, while causal treatment is left to the body's own immunity.

Yang Ping and Song Zimo stayed up all night. When Xu Zhiliang, Xia Shu, and Dr. Jin came to work in the morning, they asked to switch shifts. Now was the high fever period, and Yang Ping did not dare to relax. He asked Dr. Jin to stay by the bed, and Xu Zhiliang and Xia Shu went to the department to handle the work. He and Song Zimo took turns sleeping and resting on the bed of the accompanying person in the ward. After all, we didn't know how the disease would develop in the future, so we could sleep for a while and try to maintain sufficient physical strength to cope with future changes in the disease.

There were three nurses, several doctors and masters participating in Sisi's experiment. Yang Ping asked them to change shifts, and new personnel took over their work so that they could go back and rest.

Sisi's parents were allowed to come in for a brief visit, but they were not allowed to stay in the ward for long. After all, this kind of intensive care and treatment is not a joke, and any extra personnel would be a disruption to medical activities.

Seeing their daughter lying unconscious on the bed, the couple burst into tears and felt extremely painful, but they could not say it out loud, so as not to interfere with Professor Yang's normal treatment. After only a few minutes of visiting, Sisi's father pulled her mother and said, "Let's go."

On the bedside ECG monitor, the heart rate numbers are constantly rising and are already far beyond normal. For every degree Celsius increase in body temperature, the heart rate will increase by 12-18 times. Now Sisi's heart rate is 150 beats per minute. If this high heart rate is maintained for too long, the heart will fail.

This is the same as a car engine. If it maintains the maximum speed for a long time, it is easy to explode. The same is true for the heart. If the heart rate is maintained at a rate much higher than normal for a long time, it can easily lead to arrhythmia, heart failure, and even cardiac arrest.

Yang Ping and Song Zimo were sleeping on the companion bed next to them. Dr. Jin, who was on duty, saw that the heart rate had been slowly rising and was now likely to be over 160 beats per minute. He was not sure whether it needed to be treated, but he did not dare to make a decision on his own, so he had to wake up Yang Ping who was resting.

After Yang Ping woke up, he looked at the numbers on the monitor, then listened to Sisi's heart with a stethoscope. After listening to the heart, he stared at the ECG waveform on the monitor without any expression.

"What should we do? Should we use drugs to lower the heart rate?" Dr. Jin worriedly asked, and Song Zimo also stood up and stood beside him.

In fact, when facing such a life-and-death challenge for patients, the ability of the attending physician is extremely tested. He needs to combine his knowledge, experience and the patient's clinical manifestations to make an accurate judgment, which is related to the patient's life and death.

Yang Ping observed the electrocardiogram for five minutes without saying anything. Dr. Jin and Song Zimo were also worried. The heart rate on the monitor was now fluctuating around 160 beats per minute, and there was no guarantee that it would continue to rise.

In this situation, the heart can collapse at any time, so it is very difficult to make a choice.

Yang Ping finally spoke, and he shook his head: "No! Keep observing! If the heart rate is lowered, the drugs that lower the heart rate will inhibit myocardial contractility and lower blood pressure. Once used, the heart rate will be lowered, but the brain will be insufficiently supplied with blood due to perfusion fatigue, which can easily cause irreversible damage to brain tissue. This is likely to result in a large area of ​​brain tissue death before the heart collapses."

Dr. Jin and Song Zimo thought about it and agreed that this was indeed the case. Yang Ping's considerations were more thorough and profound.

"What should we do now?" Dr. Jin couldn't help but ask.

"Now we can only let her bear it on her own and let her own immunity deal with it. We can only deal with sudden dangers and rescue and provide life support. We can't help with other things. Everyone must stay calm and rational. A mistake in handling a detail will cause irreversible consequences."

At this time, Sisi twitched from time to time, and Yang Ping told the nurse to strengthen respiratory care to prevent suffocation during twitching. Anyway, now we have to focus on the heart and lungs, two vital organs, and deal with any abnormalities immediately.

This independent ward is fully equipped with various high-end rescue equipment. It was originally intended to be used as an independent ICU for the Surgical Research Institute. The decoration and equipment have been completed, but the staff have not yet arrived, so it is temporarily vacant. Now it is just right to be used as a laboratory ward for Sisi, so as to avoid putting Sisi in the ICU and adding huge pressure on the ICU doctors' care.

"Is it okay to have such convulsions?" Dr. Jin asked again. After all, Dr. Jin had been an orthopedic surgeon for so many years and did not have much experience with this kind of high fever convulsions in children. He felt a little worried when he saw it.

Yang Ping said with confidence: "Don't worry, leave the equipment here and let her draw the blood. We will strengthen the monitoring of her heart and lungs and pay attention to replenishing fluids and energy. We will help her get through this."

After that, Yang Ping lay down on the accompanying bed and went to sleep. Dr. Jin was very smart and steady, and Yang Ping was still very confident in him. If it were any other young doctor, Yang Ping would definitely not be confident. Lack of experience could easily lead to misjudgment, and lack of sufficient identification and early warning capabilities for some potential risks.

Around four o'clock in the afternoon, Sisi's body temperature began to drop, which meant that the viruses began to die one after another in the body. The tug-of-war between the immune system and the virus began to tilt towards the immune system, and the virus began to lose.

This is good news. Not only is Sisi very likely to survive, but there is also a very important point. Although the virus has a very different effect on the human body than the source virus, they are probably no longer the same type of virus. In other words, the addition of the K factor has completely changed the nature of the virus. It can be preliminarily estimated that the K virus is a completely new virus to the human body. The human body cannot produce antibodies to it, and can only rely on excessive and extensive immune ability to fight it. This kind of confrontation is extremely risky. If it fails, the human body will collapse. Fortunately, these viruses have lost their ability to replicate, and one less virus dies, so their combat effectiveness is extremely limited.

From the injection of K virus to now, the body temperature has shown a downward trend. The nurse has drawn a lot of Sisi's blood samples, which will be used for various tests to dynamically monitor the changes in various indicators of the human body under the influence of the virus.

In fact, some of the test reagents for these blood samples are also brand new, specially made for this laboratory, because the existing test reagents cannot detect many new indicators, such as the markers of these viruses.

I don’t know whether it is possible to find some viruses in the blood samples for research, especially to study whether the viruses have mutated in the body. Because these viruses do not have the ability to replicate, the mutations will not be inherited and are difficult to capture.

After her body temperature dropped, Sisi sweated a lot and the entire bed sheet was soaked with sweat. The nurse changed the bed sheet, changed Sisi into dry clothes, and increased the amount of fluid replacement to maintain fluid balance.

On the ECG monitor, the heart rate slowly dropped as the body temperature dropped, and Yang Ping breathed a sigh of relief temporarily.
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At Nandu Medical University, the Virology Laboratory and the Digital Medicine Laboratory are working intensively. After receiving the data from this experiment, they immediately began to correct the K virus and the experiment.

The intelligent model of the digital medical laboratory had performed virtual simulations hundreds of thousands of times and found that the probability of such a high fever was extremely low, less than one in a hundred thousand. Such a low probability event actually happened to Sisi. Either she was unlucky and encountered this one in a hundred thousand probability, or the model's prediction was wrong and the actual probability of such a high-risk result was much higher than the model's prediction.

Of course, science cannot be left to luck, so Professor He and his team assumed the latter was the cause and began to check and improve the model.

The data from this experiment is extremely valuable; it is not an animal experiment but direct clinical experimental data, which has great value for revising the model.

Professor He's team improved their model, and Professor Zhang Zhiwei was also busy. They began to further analyze the structure of the virus. Where should the K factor be implanted? What changes should be made to the genes of the source virus? These are all issues that should be reflected upon.

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They must re-analyze and summarize the structure of the virus, and it would be best if they could refer to the experimental data to make theoretical revisions to the implantation in various parts.

Professor Zhang's team also has to search for the K virus in the blood samples sent to them. Although this task is very difficult and it is difficult to find the virus in the blood now, they also want to try it. Because as long as they can find the virus, they can observe whether the virus mutates after entering the human body, whether there are any changes, and whether the implanted K factor is still playing a role.
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Sisi was still in a state of blurred consciousness, but her vital signs were stable, which gave Yang Ping great confidence.

He began to puncture Sisi's liver and lung tumors, performing precise punctures under the supervision of navigation instruments, so that some tumor cells could be removed. These tumor cells were then taken to the laboratory for analysis under an electron microscope.

This can confirm whether the K virus has successfully infected tumor cells, and if so, whether they have successfully initiated the apoptosis program of the tumor cells. If so, what the process is like.

This analysis must target tumor cells; there is no other way.

Yang Ping knew that Sisi had just escaped death, and it was still uncertain whether she could escape. Performing various punctures at this time would undoubtedly aggravate her injuries. However, if he did not seize this opportunity to perform punctures, once the opportunity was missed, even if the virus infects the tumor cells, he would not be able to obtain the true status of these tumor cells in the early, middle and late stages after infection.

To save her, we cannot be soft-hearted at this moment and must follow the principles of rationality in everything we do.

Yang Ping punctured all the metastatic tumors that could be punctured, and took many specimens to send to the electron microscope laboratory of Nandu Medical University for personal observation.

Under the electron microscope, Yang Ping searched for specimens one by one. This required great patience because the virus would be attacked by the human immune system during transportation, and it was unknown how many tumor cells it could successfully infect.

Therefore, some of the specimens collected now may be normal cells, and some may be tumor cells, but they may not be infected, because the infected cells may not have been collected at all.

Yang Ping can only go and find the specimens one by one in person. This work cannot be replaced by software models or artificial intelligence, because both software models and artificial intelligence must be based on doctors' data. These brand-new experiments do not have any historical data to feed such models, so these models are useless at all.

After looking through hundreds of shots, Yang Ping finally found an abnormal tumor cell. He immediately took out the picture of this cell for separate study. He discovered that this cell was infected by the virus because it contained the protein structure of the K virus.

But unfortunately, this cell did not undergo apoptosis, which means that the K virus did not initiate its apoptosis program. It is unknown whether it did not enter the activation program or could not be initiated at all.

Only by continuing to search and finding more virus-infected cells can we explain the problem. If all cells do not enter the apoptosis program, then these viruses may not have initiated the apoptosis program of tumor cells.

If these tumor cells are in different states, even if only one cell enters the apoptosis program, it means that the K virus can infect tumor cells and initiate its apoptosis program.

Yang Ping decided to continue searching, and Song Zimo brought several doctors and masters to help Yang Ping.

Yang Ping taught them the knowledge of reading electron microscope images and asked them to relax the indications, but they should bring any suspicious samples to Yang Ping for review, so as to reduce the number of missed specimens.