godfather of surgery

Chapter 1050 High Fever
In the virus laboratory of Nandu Medical University, the K virus has been cultivated, and the follow-up work is being carried out intensively and orderly. For this experiment, the researchers worked overtime to catch up with the time. They cherish this cooperation with Professor Yang Ping, because Yang Ping has long been a god-like figure in everyone's mind.

At this time, the researchers' faces were filled with joy and excitement, but their movements were extremely cautious. They knew that this time was different from the past. Although the source virus was safe and harmless to humans and animals, this time the virus would be used directly in human experiments, and the slightest carelessness could endanger the safety of the experimental subjects. Therefore, they always maintained a high degree of vigilance and concentration to ensure that every step was accurate and to avoid mistakes as much as possible.

Samples of the K virus will undergo a series of tests. During the testing process, researchers need to constantly observe and record data and analyze the test results. Their eyes are firm and focused, and every tiny change in the data touches their hearts.

After standardized testing, the K virus met the laboratory conditions, and everyone breathed a sigh of relief. Everyone knew that Professor Yang had a tight deadline for this experiment, so everyone tried their best to cooperate, hoping not to delay Professor Yang's experiment.

The viruses that pass the inspection will enter the packaging process, which is extremely strict. They will seal a certain amount of the virus into special biological preparation bottles in a sterile environment, make bottles one by one, and then label them and store them in the refrigerator. Just like vaccines, their storage and transportation process is a traceable cold chain.

When these K virus biological preparations that could be used in clinical trials at any time were produced, the atmosphere in the laboratory reached a climax, and the researchers cheered and celebrated with each other.

Regardless of whether this clinical trial succeeds or fails, they have taken a new step with Yang Ping. They will be the first in the world to combine the protein factor that can start the tumor cell apoptosis program with the carrier virus, artificially creating a new virus, the first virus in the world that can kill tumors, and this virus has also opened up a separate category in classification. Regardless of success or failure, their current work is to open up a new field, and as participants, they are of course very excited.

Professor Zhang Zhiwei put the preparations into the portable refrigerator for storage through the goggles of his protective suit. In the past few days, Professor Zhang has been thinking about Yang Ping's aggressive and time-consuming laboratory method. In fact, it is not all disadvantages. If other factors are not considered, objectively speaking, this method also has certain advantages.

According to the conventional procedure, the first step is computer simulation experiment, followed by animal experiment, and then phase I, II and III clinical trials, and finally clinical application. Now Yang Ping directly applies the virus to patients. In fact, he is not simply taking a blind risk, but has made a very comprehensive assessment of the virus, and the probability of risk events is very small. The current condition of the patients receiving treatment is very urgent and there is no time to wait. This is her only possible effective method.

Combining these two aspects, Yang Ping's choice is undoubtedly very smart from the perspective of risk and benefit. The immune systems of animals and humans are different, and the immune mechanisms are not exactly the same, so if we want to talk about the risks, the data accumulated in animal experiments are still very risky when used for human experiments. Therefore, even if the normal procedures are followed, clinical trials from phase I to phase III still face risks, but this risk is compliant, while the risk Yang Ping is facing now is non-compliant.

If she remains absolutely rational, even if the patient does not undergo the K virus experiment now, she does not have much time left. Even if the K virus experiment fails, she can obtain the most real and valuable data, and can immediately study and modify it. In fact, the probability of success is still very high.

After thinking about it for a few days, Professor Zhang Zhiwei felt that Yang Ping's cooperation with him in this experiment was simply a pie in the sky. If Sanbo Hospital did not have a P3 biological laboratory, I am afraid that such a good thing would not be his turn. His team only helped him cultivate the virus, and became the main participant in the experiment. This kind of experiment, regardless of success or failure, can occupy a top position in the academic world.

Thinking of this, Professor Zhang couldn't help but feel ashamed that he had done nothing but share Yang Ping's academic achievements passively. On the other hand, it can be seen that Yang Ping is also a scholar who doesn't care about these false reputations. He only considers experiments from an objective point of view and never considers false reputations. Professor Zhang respects Yang Ping from the bottom of his heart.

These young PhD students are very happy about this. What does it mean to participate in this experiment? It means that they may graduate with a CNS paper in their hands. It means that they may complete academic accumulation that others cannot complete in decades in just a few weeks.

After the K virus preparation was packed, Professor Zhang Zhiwei and two doctors personally escorted it to Sanbo Hospital.
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Just after the shift was handed over in the early morning, the special car from Nandu Medical University had arrived at Sanbo Hospital.

Professor Zhang Zhiwei personally carried the box containing the K virus biological agent, and accompanied by two doctors, he came to the independent ward of the Institute of Surgery. This ward was specially opened for Sisi to facilitate clinical experiments for her. Yang Ping spared no expense for this experiment.

Yang Ping took the box and carried it to the treatment room of the independent ward. Here, Sisi and the doctors and nurses had been waiting for a long time. Sisi had made all the preparations.

In the treatment room, Sisi lay quietly on the bed, eyes closed, breathing evenly, a catheter had been inserted into her left arm, and wires for various monitoring devices were connected to her body. Various rescue equipment was also neatly placed around her, ready to be used at any time.

She quietly waited for the start of this new treatment. Although the outcome was unknown, she was mentally prepared for the worst, so everything seemed so calm.

"It's just like getting an injection, don't be nervous." Yang Ping comforted her.

Sisi said calmly: "I'm not afraid."

The electrocardiogram waves on the ECG monitor showed that she was indeed not afraid, because her heart rate was still within the normal range and was very stable without any obvious fluctuations.

"Can we start?" asked Professor Zhang Zhiwei.

Yang Ping nodded: "Let's start."

The portable refrigerator was opened, and Professor Zhang Zhiwei personally took out the K virus biological agent from it. This agent has been designed into a disposable syringe device. After taking it out of the sealed sterile packaging box, it can be directly connected to the indwelling needle on Sisi's arm. Then it can be used as a syringe to inject the K virus liquid inside into the veins. The K virus enters the heart with the blood circulation in the blood vessels, and then is distributed throughout the body through the arterial blood. They will selectively infect tumor cells and then parasitize in the tumor cells. Once the infection is successful, they will initiate the apoptosis program of the tumor cells, allowing the tumor cells to die quietly.

The whole process is perfect in theory. But theory is theory and practice is practice. Many drugs and treatments seem perfect in theory, but they are ultimately useless after clinical tests and are cruelly eliminated. No matter how comprehensive the treatment method is in the theoretical stage, it is far inferior to the complex human body in reality.

A nurse was assisting nearby. She straightened out the indwelling needle in Sisi's arm. Yang Ping connected the preparation device to the needle and was about to push the needle when he hesitated, looked at Sisi, and did not push the needle immediately.

Sisi may have sensed something. She opened her eyes and looked up slightly, and saw Yang Ping who had not yet taken action: "Don't worry, I'm not afraid." After saying that, she made a naughty face to everyone, and the atmosphere in the treatment room was instantly relaxed. Song Zimo, Xu Zhiliang and many doctors next to them had serious faces, but they were all amused by Sisi's face and couldn't help laughing. This little girl was so relaxed.

This K virus biological agent was developed by Yang Ping and his team members after countless efforts. It carries everyone's expectations. Yang Ping knows that this is Sisi's only lifeline, and he must ensure that the injection process is foolproof.

Yang Ping carefully checked again to make sure there was no problem. Then, he gently pushed the plunger of the syringe. At this moment, everyone's heart was in their throat.

The injection began, and Yang Ping pushed the syringe carefully, fearing any mistakes. The virus biological agent slowly flowed into Sisi's body, as if a warm current of life was flowing in her blood vessels. Everyone held their breath and watched Sisi's changes nervously.

As the virus was injected, Sisi's expression did not change. Everything seemed so normal. Sisi felt no discomfort, just like she had received an ordinary painkiller injection.

Yang Ping kept an eye on Sisi's vital signs. The numbers on the ECG monitor kept jumping, showing important indicators such as her heart rate, blood pressure, and blood oxygen saturation. He knew that this battle had just begun, and in the following time, he must always be vigilant and be ready to deal with possible unexpected situations at any time.

After the injection, everyone relaxed a little, but they still dared not be careless. Sisi's condition could change at any time, so they had to stay awake and prepared at all times.

"Get up, go back to the ward and rest." Yang Ping breathed a sigh of relief. At least there were no accidents in the early stage after the injection.

Professor Zhang said as he packed up his portable refrigerator, "Let's go back first. Contact us anytime if you need anything."

Yang Ping thanked Professor Zhang's team and helped Sisi up. Watching Sisi jumping up and down from the hospital bed, the interns thought that the pressure they felt just now was unnecessary. Everything was fine now and nothing had happened.

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But Yang Ping knew that the real danger had not yet arrived. It would take a process for the virus to enter the human body and then react, rather than appearing immediately. Just like a cold, it often takes several days for cold symptoms to appear after being infected with a virus.

Yang Ping decided to stay in the department overnight and closely observe Sisi's changes. He knew that the next period of time would be their most critical test. Sisi's condition might change in a short period of time, and they must be fully prepared.

The nurses on duty took turns to guard her 24 hours a day. They kept an eye on Sisi's vital signs and recorded every slight change.

At about 24 a.m., Sisi's mother found her daughter's body was scalding hot, as if she was surrounded by a ball of fire. She panicked and called the nurse, who was accompanying her 42 hours a day in the ward, to take Sisi's temperature. The result showed that Sisi's temperature was as high as degrees Celsius, which was the limit of what the human body could bear. Yang Ping rushed over after hearing the news and immediately gave a verbal doctor's order to give Sisi a fever-reducing injection.

At the same time, he immediately ordered to use ice caps and ice blankets on Sisi, using this physical cooling method to protect her brain and important organs. He knew that high fever could cause irreversible damage to the brain and even endanger her life. Therefore, the body temperature must be lowered as soon as possible.

Soon, Sisi suffered a convulsion due to the high fever and became unconscious. Sisi's body kept twitching and she began to talk nonsense.

Yang Ping stood by the bed, closely monitoring Sisi's vital signs, ready to respond to any emergencies that might arise at any time.

All the antipyretic drugs were completely useless. Even the nasogastric administration of the Chinese patent medicine Angong Niuhuang Pills was tried, but it had no effect.

The only thing that worked was the ice cap and ice blanket. The high fever lasted for a whole night. If it weren't for the physical cooling effect of the ice cap and ice blanket, Sisi would have died long ago. Yang Ping and the nurses also stayed on duty all night. Their eyes were red and they were exhausted, but they never left their posts. They knew that they couldn't slack off even a little.

Sisi's high fever was obviously caused by the immune response after the virus was injected into her body. This new virus was like an alien invader to Sisi's immune system. Her immune system activated a wide range of defense mechanisms in a panic, causing the body temperature regulation center to go out of control and cause a high fever.

In a high fever state, the oxygen consumption of brain tissue increases sharply, and blood flow accelerates, making the brain face the threat of relative hypoxia. In order to protect this most important organ, the use of ice caps becomes crucial. It physically lowers the temperature of the head, thereby slowing down the metabolic rate of brain tissue, reducing oxygen consumption, and ensuring that the brain has a relatively adequate blood supply.

This process is a self-protection mechanism, just like hibernation in animals. In the winter when food is scarce, animals reduce their metabolic rate and body temperature to reduce their demand for food and survive the hardship. Similarly, the use of ice caps is a similar strategy to cope with this sudden shortage of oxygen.

Yang Ping knows that this fight is not just a battle against the virus, but also a race against time. He always remains highly alert and carefully observes every subtle change of Sisi. Her breathing, heartbeat, blood pressure, and even every expression, all touch his heart.

Any negligence could be fatal.

But the high fever did not subside. If it continued like this, even the ice cap and ice blanket would be of no help, because the ice cap and ice blanket only provided passive cooling, and Sisi's body would sooner or later collapse in the battle between the virus and the immune system.