Cultivation begins with alchemy and collecting runes.

Li Xiuyuan transmigrated to the world of cultivation, becoming a pill-refining handyman at the Dan Ding Sect. Seeking immortality, he tested poisons on himself, becoming afflicted with pill toxins and left with only six months to live. One day, he awakened Su Hui, unlocking a proficiency panel. His proficiency in alchemy, weapon crafting, and cultivation all increased, his skills becoming permanent, turning his desperate handyman life around! He refined the Bigu Pill, refining the rune [Qi Qing Yun Yuan], doubling its efficacy, abstaining from hunger for 60 days, nourishing his physical body; he refined the Dragon and Phoenix True Spirit Pill, refining the rune [Dragon and Phoenix Nine Heavens], transforming himself into a true dragon and phoenix, his ferocious power destroying the heavens and earth; he refined the Thunder Tribulation Pill, refining the rune [Thunder Tribulation Immortal Body], tempering himself against the thunder tribulation, severing the tribulation and crossing the gate to immortality! ... Billions of years later, eras shifted, and the former handyman Li Xiuyuan refined supreme runes such as [Immune to All Poisons], [Burning Heaven and Boiling Seas], [Sword Qi Star River], and [Undying Through Ten Thousand Tribulations]. His fingertips shimmered with celestial light, and he laughed loudly, "I am the Supreme One, Profound and Subtle Heavenly Venerable. Today I attain immortality!" [Mortal Journey] [Farming Journey] [Proficiency] [Steady Development] [Miscellaneous Immortal Cultivation Story]