MYGO's guitarist has ice attribute bonus

"Really." Seeing that everyone was unconvinced, Aine explained quietly, "Actually... as early as the initial surgery, I had already prepared myself mentally. At that time, I thought I would die during the operation..."

Just as Aine finished her last word, her mouth was suddenly covered by Mu.

Mu looked at Aine with tears in her eyes, her voice trembling: "Aine-chan, no...don't talk nonsense."

Seeing Aiyin nod, Mu slowly loosened her grip. Aiyin gently held Mu in her arms and continued, "Now, there is hope for a complete recovery, so I will continue..."

Li Xi shook his head: "But Aiyin, if you don't want surgery, just conservative treatment like this, you can stay with us for a long time..."

Xiangzi nodded: "Yes, Xiaoai, why... do you have to undergo that operation that has no chance of success?"

After hearing Xiangzi's words, the others nodded.

Seeing this, Aine smiled slightly, with a hint of relief: "Because... I have already made a promise... to form a band with Tomorin and the others for life."

"No." Su Shi's voice was hoarse, and she shook her head desperately, "I clearly said it before, how can a band... compare to you..."

Deng also nodded, tears welling up in her eyes. She didn't expect Aine to have been working hard for this promise: "Aine-chan...that vow is not important...I just hope that you can stay with me...with all of us, that's all."

“Soyorin, Tomorin, there must be more than one reason for me to continue with the surgery.” Aine shook her head gently, “I really want to get better… I’m so tired… Watching myself lose my ability to move clearly is really painful…”

Aine's tone was soft, yet it left no room for doubt.

Su Shi and Deng were silent. What Aine said was indeed true. They did not consider Aine's perspective and whether she could accept living her whole life with such physical condition.

"I...want to get better, and then go out for a good stroll with you and Mom and Dad, as a normal person."

After that, everyone else fell silent.

"Then..." Su Shi took a long breath and asked, "Why didn't you tell us earlier?"

Aine replied weakly, "I...I'm afraid you won't agree."

"Xiao Ai, are you sure... you really need surgery?" Chu Hua asked again.

“Yeah.” Aine nodded lightly, her tone firm.

Hailing looked at Aine quietly. The pink-haired girl's eyes were unusually determined, which made Hailing a little dazed.

"Aine-chan...I really don't want you to go." Mu slowly let go of Aine and sobbed softly, "But...if you really want to, I won't stop you."

"Thank you, Mumu, it's okay."

Miao Meng looked at Aiyin for a long time, then she opened her lips and said, "Aizi..."

Aiyin fixed her gaze on Miaomeng. Seeing the latter's reluctant look, she chuckled, "I understand, Miaomeng dear. After my surgery is finished, let's take a photo together, shall we?"

"Yeah, okay." Miao Meng nodded.

"Aine...are you really going?" Le Na, who had been watching from the side, couldn't help but speak at this moment.

“Yeah,” Aine nodded, “When I get better, we can play guitar together again.”

"Play the guitar..." Lenai sat blankly in the chair, muttering to himself.

Aine tilted her head slightly, "Runa-chan?"

This was the first time Aine saw Lenai not show excitement when hearing the words "play guitar".

After a brief hesitation, Lena nodded. She stood up from her chair, walked over to Aine, and extended her pinky finger. "Okay, it's a deal. Let's play guitar together later."

"Okay." Aine agreed, and after making a pinky promise, Lenai turned around and sat back in the chair.

"Since Xiao Ai'ai has this idea, then I have nothing more to say." Xiangzi sighed helplessly, "Everyone will always be waiting for you."

Seeing the others nodding, Aine's nose felt sore: "Yeah, I understand."

……

Time passed quickly, and in the blink of an eye, it was a month later, and the surgery was about to begin.

The reason why the surgery was performed only one month apart was because Dr. Yamada did not want to waste the foundation laid by the nerve reconstruction surgery. In this way, the effect of the microenvironment regulation surgery could be maximized.

As for the cytokine storm that gives doctors a headache, there is no good way to completely eliminate it, let alone within a few months, even within a few years.

In the ward, Aine was half lying on the bed, her eyes fixed on the door of the ward, always watching for when Dr. Yamada would come in.

"Xiao Ai, don't be nervous." Chu Hua sat next to Ai Yin and spoke to comfort her.

"Chuhua, before telling Aiyin-chan not to be nervous, you should be the first to not be nervous." Su Shi held his forehead and said helplessly.

"Ah? Sorry... I'm sorry." Chu Hua wanted to stop his trembling hands, but he couldn't do it no matter what.

Although everyone was there in the ward, it was unusually quiet.

Everyone's eyes were focused on the clock on the wall and the door of the ward.

Nine o'clock in the morning was the time Dr. Yamada had scheduled for the surgery, and it was already half past eight.

"Tick, tick..." The only sound in the ward was the ticking clock.

Xiangzi sat next to Aine, holding Aine's hand tightly, as if if he let go, he would never see Aine again.

"Clap clap clap..."

Unlike in the ward, footsteps were heard in the corridor.

After hearing the footsteps, everyone became nervous and stared at the door of the ward - Xiangzi and the others were very scared, afraid that the footsteps were from Dr. Yamada and others.

Now they just hope that time will pass slower and slower...

"Boom."

But unfortunately, their thoughts were dashed. Doctor Yamada pushed open the door of the ward, glanced inside, and then set his sights on Aine: "Chihaya-san, it's time for surgery."

After hearing this, Xiangzi and the others subconsciously straightened their bodies. Su Shi turned around and looked at Ain reluctantly.

After noticing everyone's expressions, Aine smiled, the sunlight falling on her face: "It's okay, it's just an operation, don't worry."

“Aine-chan…” Deng’s body trembled slightly.

"Well, bye everyone, I'm going to the operating room first."

After Aine finished saying this, the nurse following behind Dr. Yamada pushed Aine's bed out of the ward.

On the way, Dr. Yamada looked at Aine lying on the hospital bed and said softly, "Chihaya-san, are you scared?"

“Well… a little bit.” Aine nodded, expressing her true feelings.

"For this final major surgery, I've discussed it with the other departments and the director," said Dr. Yamada, standing by. "We've called in the heads of anesthesiology, neurosurgery, and immunology."

"Eh? Three directors?" Aine widened her eyes in disbelief. For her, it was difficult to see one director during surgery, let alone three directors at once.

Dr. Yamada nodded. "Yes, the other three directors were also very interested in ALS rehabilitation surgery. It just so happened that they hadn't performed the surgery themselves, so they all agreed to the offer."

Chapter 382 Cytokine Storm

Seeing Aiyin being pushed into the operating room, Xiangzi and the others following behind finally stopped.

"Xiao Xiang..." Deng held Xiangzi's hand tightly.

Feeling the warmth in Deng's hand, Xiangzi stopped his trembling body: "It's okay, Deng."

Looking at Aine who was pushed in, the director of neurosurgery glanced at the circulating nurse and the instrument nurse. The nurses understood and began to prepare for the operation.

After the nurse connected various tubes to Aine, the imaging doctor used intraoperative MRI to locate the target area, and the director of the anesthesia department confirmed that local anesthesia was complete, the director of neurosurgery took a deep breath and began to prepare for the operation.

The cold light from the shadowless lamp poured down, shrouding the operating table in a dazzling pure white.

Aine was lying on her side on the operating table, her body covered with sterile cloth, with only the surgical area on her spine exposed.

The smell of disinfectant rushed into Aiyin's nose, mixed with the low humming sound of the precision instruments in operation in her eyes. The last major operation - CAR-Microglia microenvironment surgery officially began.

As long as she succeeds and eliminates the remaining SOD1 mutant protein clusters in her body, her road to recovery will be smooth and jumping and running will no longer be a fantasy.

Returning to the playground in Hanedaoka, returning to the live stage, returning to everyone as a normal person - these thoughts have been supporting Aine, allowing her to endure the pain of multiple gene editing and nerve reconstruction.

Dr. Yamada looked at this precision instrument, which was one of the instruments that Xiangzi gave to their hospital. It was also the latest scientific research product from the United States.

"Chihaya, are you ready? We are about to start." Dr. Yamada leaned over, his voice a little blurry through the mask, but the eyes behind the lenses were calm and focused.

He looked up at the head of neurosurgery, who nodded slightly, understanding.

"Yeah." Aine blinked, her long eyelashes casting a small shadow under the light. She suppressed her inner anxiety, closed her eyes and calmly waited for the surgery to begin.

On the huge neuronavigation screen behind the director of neurosurgery, a three-dimensional image of Aine's diseased area was clearly outlined, with several glaring red dots representing abnormal protein clumps dotted around it.

The operating room was very quiet, with only the low hum of instruments.

Soon, the head of neurosurgery completed the first step of the operation - minimally invasive drilling.

He glanced at the target area on the screen and carefully manipulated the microcatheter and biomaterial under the microscope. Guided by precise navigation, he safely passed through the interstitial space and finally and steadily arrived at a glaring cluster of abnormal protein. Aine felt a very slight pressure on the back of her neck.

"Injection." The director of neurosurgery gave clear instructions.

Along the catheter, billions of genetically engineered viral vectors are precisely released into the target area.

"The carrier release is complete, and the induction signal is activated." The director of neurosurgery stared coldly at the bioelectric feedback graph on the screen.

Invisible bioelectric signals were precisely released, and in an instant, the CAR-Microglia cells in Ain's body were fully activated and began to devour the pathogenic SOD1 mutant protein clumps.

On the screen, the glaring red dots began to shrink and fade at a speed visible to the naked eye.

"Blood pressure is 110/70, heart rate is 75, oxygen saturation is 99 percent, and ventilator parameters are stable." The director of the anesthesiology department made a routine report.

Dr. Yamada looked at the data on the instrument: "The concentration of SDO1 mutant protein in the target area has decreased by twenty percent... forty-two... sixty-five percent."

His voice was filled with uncontrollable excitement as he clearly reported the data: "Neuroelectrophysiological signal conduction blockage has weakened, and conduction velocity has increased by ten percent."

The oppressive atmosphere in the operating room was slightly softened by these readings, and the cold instruments and even the lights in the operating room became much softer.

The head of neurosurgery nodded gently. "Very good. The immunology department is always on the lookout for unexpected events. The operation will continue."

There was no need for special instructions. The director of the immunology department stood in front of the screen the whole time. The reason he didn't sit down was because he was afraid that if something unexpected really happened, getting up would waste time. He knew very well that this operation could not be delayed at all.

After clearing one cluster of protein, the director of neurosurgery manipulated the microcatheter to reach another cluster of mutant protein and began to clear it.

His eyes swept over Aine's profile, and he felt a slight sense of relief. After the operation was successful, this girl would be able to slowly return to her normal life... Thinking of this, he felt really motivated. For a child like this...

The clearing effect far exceeded expectations, and the regulatory signal was so positive. This was a phenomenon that Dr. Yamada and his team had never seen in previous experiments. The balance of victory had never been so in their favor.

Just as the director of neurosurgery began to clean up the next protein mass, the director of immunology frowned and said, "That's not right!"

The sudden sound interrupted the operation and everyone's eyes were on him.

Without time to think, the director of the immunology department suddenly looked at the circulating nurse and said, "Go prepare tocilizumab!"

He had just clearly seen an abnormal fluctuation in blood pressure. Although it was only a tiny value, as the director of the immunology department, he was confident enough in his judgment.

Hearing this, the circulating nurse hurriedly prepared to inject Tocilizumab, but before she could begin...

“Ding ding ding——!!!”

A sharp, shrill alarm sounded without warning, powerful enough to rip the eardrums apart, instantly drowning out the low hum of all the instruments!

It is not a single device that alarms, but all the monitoring instruments in the entire operating room.

"Abnormal ECG, blood oxygen, blood pressure... body temperature has reached 38.5 degrees and is still rising..." The director of the Department of Anesthesiology stood up. It was obvious that it was a cytokine storm - the most difficult opponent for them at the moment.

On the screen, Aine's life curve was no longer a gentle fluctuation, but turned into a wildly jumping sawtooth and a cliff-like fall!

血压监测柱瞬间从健康的绿色跌入刺目的深红，数值断崖式暴跌；心率从平榴1霓亦 児坝罒肆紦稳的70飙升到180……甚至还在升高；心电图的波形变成扎眼的扭曲；血氧饱和度的那个“98”眨眼间变成了令人窒息的“75”。

"Maximum dose of tocilizumab! Impact of methylprednisolone! Quick! Open all pathways! Prepare for plasma exchange!" The director of the immunology department had never encountered such a difficult cytokine storm. Cytokine storms were already a headache for ordinary patients, not to mention that Aiyin was an ALS patient. Just one breath was enough to give them a headache.

After briefly assessing the data on the screen, the head of the Immunology Department's face darkened. "Level 4 cytokine storm. Watch for organ failure. The ECMO team is ready."

Level 4 cytokine storm is the highest level of all cytokine storms and has the highest mortality rate.

The mortality rate for ordinary people who experience this is as high as a terrifying 80%, let alone a patient with ALS?

Chapter 383 Critical Illness Notice

A level 4 cytokine storm erupted without warning within Aine's body. The overactivated, completely frenzied immune system, no longer distinguishing friend from foe, unleashed a frenzied, devastating wave of damage.

The surging inflammatory factors roared through Aine's delicate blood vessels like a raging wave, destroying everything in its path. The endothelium of her blood vessels was torn, and blood oozed out frantically. At this moment, red spots could be clearly seen through Aine's skin.

Flooded with inflammatory fluid, the alveoli lost their ability to exchange oxygen; myocardial cells convulsed in agony under the combined assault of toxins and hypoxia; the filtering units of the kidneys necrotized in patches, and metabolic waste began to accumulate in the blood.

Aine felt an intense pain, a pain unlike any she'd felt during surgery. It was a tearing, burning, and suffocating sensation coming from deep within her body, as if countless blades were tumbling through her, slicing her apart. Her body began to twitch violently, unintentionally, like an autumn leaf in a cold wind...

But soon, as her brain became deprived of oxygen and metabolic toxins accumulated, her consciousness gradually faded. All those memories of school, family, friends, and the future... like shattered bubbles, they disappeared into the endless darkness.

All that remained was a heavy, dead silence, an unspeakable coldness, and... the distant and blurry sound of alarms in the operating room.

The alarms from the monitors grew louder and louder, merging into a tide of death.

After the operation was aborted, the hands of the director of immunology, the director of anesthesia, and the circulating nurse flew over her, emptying syringes of expensive antagonists one after another. The plasma was quickly replaced like a red stream and new ones were injected in.